A5100602639- Global Maternal and Child Health
- Healthcare Systems and Reforms
- Injury Epidemiology and Prevention
- Pharmacological Effects of Natural Compounds
- Epilepsy research and treatment
- COVID-19 epidemiological studies
- Traffic and Road Safety
- Neuroscience and Neuropharmacology Research
- Infectious Encephalopathies and Encephalitis
- Pharmacological Effects and Toxicity Studies
- Natural product bioactivities and synthesis
- Pediatric health and respiratory diseases
- Nutritional Studies and Diet
- Cancer-related molecular mechanisms research
- Canadian Identity and History
- Healthcare Policy and Management
- Cytokine Signaling Pathways and Interactions
- Melanoma and MAPK Pathways
- Wireless Power Transfer Systems
- China's Global Influence and Migration
- Botanical Studies and Applications
- Phytochemistry and Bioactive Compounds
- Advances in Cucurbitaceae Research
- Flavonoids in Medical Research
- Interconnection Networks and Systems
West China Second University Hospital of Sichuan University
2020-2025
Sichuan University
2020-2025
Henan Cancer Hospital
2024
Zhengzhou University
2024
Sichuan Agricultural University
2024
Shaanxi Provincial Hospital of Traditional Chinese Medicine
2024
Brigham and Women's Hospital
2024
Harvard University
2024
Broad Institute
2024
National Wheelchair Basketball Association
2024
The unc-13 homolog B (UNC13B) gene encodes a presynaptic protein, mammalian uncoordinated 13-2 (Munc13-2), which is highly expressed in the brain-predominantly cerebral cortex-and plays an essential role synaptic vesicle priming and fusion, potentially affecting neuronal excitability. However, functional significance of UNC13B mutation human disease not known. In this study, we screened for novel genetic variants cohort 446 unrelated cases (families) with partial epilepsy without acquired...
Abstract Background Deep learning (DL), a specialized form of machine (ML), is valuable for forecasting survival in various diseases. Its clinical applicability real-world patients with gastric cancer (GC) has yet to be extensively validated. Methods A combined cohort 11,414 GC from the Surveillance, Epidemiology and End Results (SEER) database 2,846 Chinese dataset were utilized. The internal validation different algorithms, including DL model, traditional ML models, American Joint...
Under-5 mortality rate is an important indicator in Millennium Development Goals and Sustainable Goals. To date, no nationally representative studies have examined the effects of fine particulate matter (PM2.5) air pollution on under-5 mortality.To investigate association short-term exposure to PM2.5 with from total specific causes China.We used national Maternal Child Health Surveillance System identify cases during study period 2009 2019. We adopted a time-stratified case-crossover design...
<title>Abstract</title> <bold>Background</bold> The neonatal mortality rate (NMR) is a vital indicator for assessing maternal and child health, preterm birth one of the leading causes mortality. Since 2010, China has implemented multiple health policies aimed at reducing However, systematic research on urban-rural disparities in among births remains relatively scarce. In this study, we analyzed national subnational cause-specific death rates neonates mainland during 2010 to 2021 provide data...
The present study estimated the national and urban-rural levels causes of neonatal deaths in China annually between 2014 2018 to provide data support for further end preventable other low-income middle-income countries.The was based on from National Maternal Child Health Surveillance System. All neonates surveillance districts (gestational week: ≥28 weeks) who died after delivery have been involved study. mortality rate leading death were analysed.The (NMR) has steadily decreased 5.9 per...
Intronic (TTTCA)n insertions in the SAMD12, TNRC6A, and RAPGEF2 genes have been identified as causes of familial cortical myoclonic tremor with epilepsy.To identify cause epilepsy pedigrees without RAPGEF2.Repeat-primed polymerase chain reaction, long-range Sanger sequencing were performed to existence a novel (TTTGA)n insertion. Targeted long-read was confirm accurate structure insertion.We expanded intronic insertion at same site previously reported SAMD12. This cosegregated 1 Chinese...
To evaluate the impact of a model rural community health service (CHS) on use and acceptability primary healthcare services.Quasi-experimental.Two adjacent counties in China.5842 residents 2009 3807 2010 from 980 households 7 intervention townships 49 villages; 2232 2315 628 3 comparison 9 villages. All were approached to participate, with no significant differences age or sex between groups.Multilevel including training practitioners, encouraging clinic improvements, providing clinical...
Soybean is an important global crop for edible protein and oil, plant height a main breeding goal which closely related to its shape yield. In this research, high-density genetic linkage map was constructed by 1996 SNP-bin markers on the basis of recombinant inbred line population derived from Dongnong L13 × Henong 60. A total 33 QTL were identified, five repeatedly detected in multiple environments. addition, 455-germplasm with 63,306 SNP used multi-locus association analysis. 62 QTN...
Abstract Background Accidental drowning of children under five is a serious problem in China. The present study analyzed data on environmental and sociodemographic factors primary caregivers drowned to understand that may contribute this problem. Methods collected information 563 cases from October 1, 2015, September 30, 2016, 334 sampling districts Primary were interviewed individually using the Drowning Mortality among Children 5 Questionnaire. Results Most years old boys, 71.6% lived...
In order to improve the scientific fitness level of women and connect with National Fitness plan Healthy China strategy, this study analyzes key technical components for Chinese proposes corresponding improvement strategies.Research suggests that current in mainly includes three technologies: theoretical research on health assessment guidance, development integrated systems construction a comprehensive intervention system fitness. The strategies from five aspects: forming policy guarantees...
Introduction: We applied multi-omics to study individual responses dietary interventions and their effects on the gut microbiome in a long-term randomized controlled trial of Mediterranean Diet (MedDiet). Methods: profiled host genetics (Global Screening Array), (shotgun metagenomics), fecal plasma metabolomics (LC-MS) at baseline endpoint 18-month DIRECT-PLUS Trial with 294 participants into three groups: healthy guidelines, MedDiet + polyphenols (Fig. 1A). Results: observed large...
Chrysoeriol, a natural flavonoid, has shown potential in inhibiting melanoma. However, the detailed molecular mechanisms of its action still need to be clarified. In this study, chrysoeriol showed significant suppressive effects on melanoma progression mouse model. The integrative gut microbiota and metabolomic analyses revealed that modulates multiple pathways associated with apoptosis, necroptosis, pyroptosis, ferroptosis. Morphological changes chrysoeriol-treated cells PANoptosis-...
Bile acids (BAs) undergo extensive microbial metabolism in the gut and exert hormone-like functions on physiological processes underlying metabolic risk. However, extent to which BA profiles predict cardiometabolic risk explain individual responses dietary interventions humans is still unclear. In DIRECT-PLUS Trial, we conducted a multi-omics analysis of 284 participants randomized into three groups: healthy guidelines two Mediterranean diet (MedDiet) groups. We longitudinally measured 44...
To introduce a model of community health service organization (as implemented in urban areas) to less developed rural areas China and evaluate the impact this on care utilization. The intervention involved developing leadership at county level, training practitioners, providing clinical management guidelines standards, encouraging clinic improvements access subsidies for public work. We chose 7 townships 49 administrative villages Chongyi County as sites; 3 9 Luxi comparison sites. Officers...
Road traffic injuries (RTIs) have become a considerable issue for children. In China, RTIs are among the top 3 contributors to injury-related mortality and disability-adjusted life years. The present study aimed evaluate social environmental factors that may contribute children under 5 in rural areas of China.The was based on 1 year data (October 1, 2015 September 30, 2016) from National Maternal Child Health Surveillance System (NMCHSS) all districts 334 Districts 30 Chinese provinces,...
Plant roots and soil prokaryotes primarily interact with each other in the rhizosphere. Changes rhizosphere prokaryotic structure are influenced by several factors. In this study, community of Potentilla anserina L. was identified evaluated high-throughput sequencing technology different continuous cropping fields developmental stages plant. total, 2 archaeal (Euryarchaeota Thaumarchaeota) 26 bacterial phyla were P. The mainly composed Acidobacteria, Actinobacteria, Bacteroidetes,...
Hepatocellular carcinoma (HCC) has been a highly common and pathological disease worldwide, while current therapeutic regimens have limitations.
This study deeply discusses the specific application of information technology in basketball teaching. Through by teachers, it is found that influential factors teaching are mainly composed teachers' "cognition", "willingness" and "application". The correlation analysis three dimensions showed that: gender teachers had no significant difference cognition, intention information-based (p>0.05); There were differences (P<0.01). among educational background (p>0.05). Based on case...
Background: The Juan-Bi decoction (JBD) is a classic traditional Chinese medicines (TCMs) prescription for the treatment of rheumatoid arthritis (RA). However, active compounds JBD in RA remain unclear. Aim: aim this study to screen effective using systems pharmacology and experimental approaches. Method: Botanical drugs were acquired from multiple public TCM databases. All initially screened absorption, distribution, metabolism, excretion, toxicity (ADMET) physicochemical properties, then...