A5056856819- Genetic diversity and population structure
- Evolution and Genetic Dynamics
- Genetic and phenotypic traits in livestock
- Mathematical and Theoretical Epidemiology and Ecology Models
- Genetic Mapping and Diversity in Plants and Animals
- Evolutionary Game Theory and Cooperation
- Nutrition, Genetics, and Disease
- RNA regulation and disease
- Identification and Quantification in Food
- Stochastic processes and statistical mechanics
- melanin and skin pigmentation
- Statistical Methods in Clinical Trials
- Genetics and Neurodevelopmental Disorders
- Bayesian Methods and Mixture Models
- Neurological disorders and treatments
- Biochemical Analysis and Sensing Techniques
- Neurogenetic and Muscular Disorders Research
- Remote Sensing and Land Use
- Acute Myeloid Leukemia Research
- Forensic and Genetic Research
- Optimal Experimental Design Methods
- DNA Repair Mechanisms
- Glycogen Storage Diseases and Myoclonus
- 14-3-3 protein interactions
- Mathematical Biology Tumor Growth
Jilin University
2018-2024
University of Bristol
2008-2023
Hunan University of Traditional Chinese Medicine
2021
Guangzhou Medical University
2019
Capital Normal University
2014-2016
Jining Medical University
2014
The First Hospital of Kunming
2008
University of Oxford
2007
University of British Columbia
2007
Roswell Park Comprehensive Cancer Center
1997-1999
Familial cortical myoclonic tremor with epilepsy is an autosomal dominant neurodegenerative disease, characterized by and epileptic seizures. Although four subtypes (types 1–4) mapped on different chromosomes (8q24, 2p11.1-q12.2, 5p15.31-p15.1 3q26.32-3q28) have been reported, the causative gene has not yet identified. Here, we report genetic study in a cohort of 20 Chinese pedigrees familial epilepsy. Linkage haplotype analysis 11 revealed maximum two-point logarithm odds (LOD) scores from...
Abstract To identify genes that regulate the dynamics of lipid droplet (LD) size, we have used genetically tractable model organism Caenorhabditis elegans, whose wild-type LD population displays a steady state size with an upper limit 3 μm in diameter. From saturated forward genetic screen 6.7 × 105 mutagenized haploid genomes, isolated 118 mutants supersized intestinal LDs often reaching 10 μm. These define nine novel complementation groups, addition to four known (maoc-1, dhs-28, daf-22,...
The molecular defects responsible for tumorigenesis in adult de novo acute myeloid leukemia (AML) with a normal karyotype or an additional copy of one chromosome (i.e., trisomy) remain largely unknown. We recently discovered that approximately 90% patients AML and trisomy 11 (+11) as sole abnormality 11% cytogenetics carry rearrangement the ALL1 (MLL, HRX, HTRX) gene. rearranged gene has been shown to result from direct tandem duplication portion itself. To better understand underlying...
Intronic (TTTCA)n insertions in the SAMD12, TNRC6A, and RAPGEF2 genes have been identified as causes of familial cortical myoclonic tremor with epilepsy.To identify cause epilepsy pedigrees without RAPGEF2.Repeat-primed polymerase chain reaction, long-range Sanger sequencing were performed to existence a novel (TTTGA)n insertion. Targeted long-read was confirm accurate structure insertion.We expanded intronic insertion at same site previously reported SAMD12. This cosegregated 1 Chinese...
As one of the most severe pollutants, cadmium has been reported to be harmful plant cells, but effects on gymnosperm pollen germination and tube growth mechanism this involvement are still unclear. Here, we report that not only strongly inhibited P. wilsonii growth, also significantly altered morphology in a dose-dependent manner. Time-lapse images obtained with laser scanning confocal microscope revealed endocytosis was dramatically by stress. Further investigation ER-Tracker dye indicated...
Recent advances in DNA sequencing techniques have made it possible to monitor genomes great detail over time. This improvement provides an opportunity for us study natural selection based on time serial samples of while accounting genetic recombination effect and local linkage information. Such series genomic data allow more accurate estimation population parameters hypothesis testing the recent action selection. In this work, we develop a novel Bayesian statistical framework inferring at...
We consider the spatial $\Lambda $-Fleming-Viot process model for frequencies of genetic types in a population living $\mathbb {R}^{d}$, with two individuals ($0$ and $1$) natural selection favouring type $1$. first prove that is well-defined provide measure-valued dual encoding locations "potential ancestors" sample taken from such population, same spirit as SLFV without [7]. then cases, one which dynamics are driven by purely "local" events (that is, reproduction bounded radii)...
We consider the accumulation of beneficial and deleterious mutations in large asexual populations. The rate adaptation is affected by total mutation rate, proportion population size N. show that regardless rates, as long strictly positive, at least $\mathcal{O}(\log^{1-\delta}N)$ where δ can be any small positive number, if sufficiently large. This shows genome modeled continuous, there no limit to natural selection, is, grows N without bound.
Temporally spaced genetic data allow for more accurate inference of population parameters and hypothesis testing on the recent action natural selection. In this work, we develop a novel likelihood-based method jointly estimating selection coefficient allele age from time series frequencies. Our approach is based hidden Markov model where underlying process Wright-Fisher diffusion conditioned to survive until most sample. This formulation circumvents assumption required in existing methods...
Novel technologies for recovering DNA information from archaeological and historical specimens have made available an ever-increasing amount of temporally spaced genetic samples natural populations. These time series permit the direct assessment patterns temporal changes in allele frequencies hold promise improving power inference selection. Increased resolution can further facilitate testing hypotheses regarding drivers past selection events such as incidence plant animal domestication....
We explore the effect of different mechanisms natural selection on evolution populations for one- and two-locus systems. compare viability fecundity in context Wright-Fisher model with under assumption multiplicative fitness. show that these two modes correspond to orderings processes population regulation model. find can affect distribution trajectories haplotype frequencies evolving genetic recombination. However, difference is only appreciable when significant linkage disequilibrium. as...
Abstract Over the past decade there has been an increasing focus on application of Wright-Fisher diffusion to inference natural selection from genetic time series. A key ingredient for modelling trajectory gene frequencies through is its transition probability density function. Recent advances in DNA sequencing techniques have made it possible monitor genomes great detail over time, which presents opportunities investigating while accounting recombination and local linkage. However, most...
We consider a biological population in which beneficial mutation is undergoing selective sweep when second arises at linked locus. investigate the probability that both mutations will eventually fix population. Previous work has dealt with case where to arise confers smaller benefit than first. In size plays almost no rôle. Here we opposite and observe that, by contrast, of fixing can be heavily dependent on size. Indeed key parameter $rN$, product recombination rate between two selected...
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In the present study, complete mitochondrial DNA sequence of Pallas’s Leaf Warbler (Phylloscopus proregulus) was determined for first time. The genome is a circular molecule 16,880 bp in size and contains 13 protein-coding genes, 2 rRNA 22 tRNA genes control regions. base composition 32.7% C, 14.3% G, 30.0% A 23.0% T. These data will be useful studying genetic diversity within species phylogenetic relationships among different Phylloscopidae species.
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by authors. Any queries (other than missing content) should be directed to corresponding author article.
OBJECTIVES:To explore the characteristics of variations in patients with nonsyndromic hearing impairment (NSHI) Southern China to supply a theoretical basis for screening, intervention, and prevention. MATERIALS METHODS:A total 634 hearing-impaired students from special schools deaf 220 normal-hearing individuals South were tested using an allele-specific polymerase chain reaction-based universal array, screened SLC26A4 mutation carrier was examined computed tomography.The pathogenesis...
With the rapid growth of number sequenced ancient genomes, there has been increasing interest in using this new information to study past and present adaptation. Such an additional temporal component promise providing improved power for estimation natural selection. Over last decade, statistical approaches detection quantification selection from DNA (aDNA) data have developed. However, most existing methods do not allow us estimate timing along with its strength, which is key understanding...