A5056800670- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Respiratory Support and Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Neonatal Respiratory Health Research
- Radiation Dose and Imaging
- Advanced Radiotherapy Techniques
- Immune Response and Inflammation
- AI in cancer detection
- Lung Cancer Treatments and Mutations
- Landslides and related hazards
- Cardiac Ischemia and Reperfusion
- Hydrocarbon exploration and reservoir analysis
- Geological and Geophysical Studies
- Autophagy in Disease and Therapy
- Lung Cancer Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Tryptophan and brain disorders
- Thermal Regulation in Medicine
- Neuroinflammation and Neurodegeneration Mechanisms
- S100 Proteins and Annexins
- RNA modifications and cancer
- Geological Studies and Exploration
- Genetic factors in colorectal cancer
Guizhou Electric Power Design and Research Institute
2023-2025
PowerChina (China)
2023-2025
Zhejiang Chinese Medical University
2024
Guangzhou Medical University
2022-2024
Hainan Medical University
2023
National Defense Medical Center
2013-2023
Hangzhou City University
2023
State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering
2023
Hohai University
2023
City University of Macau
2023
Background Immunotherapy has become an important treatment option for patients with advanced non-small cell lung cancer (NSCLC). At present, none of these existing biomarkers can effectively stratify true responders and there is urgent need identifying novel biomarkers. Exosomes derived from the serum have been proven to be reliable markers diagnosis. Here, we explored possibility using plasma-derived exosomal microRNAs as potential optimal selection EGFR/ALK negative NSCLC immunotherapy....
Abstract Ischemic stroke is a refractory disease that endangers human health and safety owing to cerebral ischemia. Brain ischemia induces series of inflammatory reactions. Neutrophils migrate from the circulatory system site accumulate in large numbers at inflammation across blood–brain barrier. Therefore, hitchhiking on neutrophils deliver drugs ischemic brain sites could be an optimal strategy. Since surface has formyl peptide receptor (FPR), this work modifies nanoplatform by...
Purpose: Leptomeningeal metastases are more common in non-small cell lung cancer (NSCLC) with EGFR mutations. The diagnosis is difficult by traditional imaging only, and leads to poor understanding of resistance mechanisms leptomeningeal metastases.Experimental Design: We compared the CellSearch Assay, Thinprep cytologic test (TCT), brain magnetic resonance (MRI) 21 NSCLC patients suspected metastases. Next-generation sequencing that included 416 cancer-associated genes was also performed on...
Endoplasmic reticulum (ER) stress that disrupts ER function can occur in response to a wide variety of cellular factors leads the accumulation unfolded and misfolded proteins ER. Many studies have shown amplified inflammatory reactions was involved various diseases. However, little is known regarding role hyperoxia-induced acute lung injury (HALI). This study investigated influence inhibitor, 4-phenyl butyric acid (4-PBA), mice with HALI. Treatment 4-PBA hyperoxia groups significantly...
Background US-based diagnosis of thyroid nodules is subjective and influenced by radiologists' experience levels. Purpose To develop an artificial intelligence model based on American College Radiology Thyroid Imaging Reporting Data System characteristics for diagnosing identifying nodule (hereafter, MTI-RADS) to compare the performance MTI-RADS, radiologists, a trained benign malignant status surgical histopathologic analysis MDiag). Materials Methods In this retrospective study, 1588...
SpyTag is a peptide that can form an irreversible covalent linkage to its 12 kDa partner SpyCatcher via spontaneous isopeptide bond. Herein, we fused at the N-terminal of lichenase and C-terminal so termini were locked together by interaction between partners. In addition, elastin-like polypeptides tag was subsequently attached C-terminus SpyCatcher, thereby facilitating non-chromatographic purification cyclized lichenase. The study showed optimum temperature about 5 °C higher in comparison...
Chest computed tomography (CT) image data is necessary for early diagnosis, treatment, and prognosis of Coronavirus Disease 2019 (COVID-19). Artificial intelligence has been tried to help clinicians in improving the diagnostic accuracy working efficiency CT. Whereas, existing supervised approaches on CT COVID-19 pneumonia require voxel-based annotations training, which take a lot time effort. This paper proposed weakly-supervised method lesion localization based generative adversarial...
Annexin A1 (AnxA1) is an endogenous protein that modulates anti-inflammatory processes, and its therapeutic potential has been reported in a range of inflammatory diseases. The effect AnxA1 on ischemia-reperfusion (IR)-induced lung injury not examined. In this study, isolated, perfused rat lungs were subjected to IR induced by ischemia for 40 min, followed reperfusion 60 min. randomly treated with vehicle (phosphate-buffered saline), Ac2-26 (an active N-terminal peptide AnxA1) or without...
Osteosarcoma is a primary malignant bone tumor that has high potential to metastasize lungs. Little known about the mechanisms underlying dissemination of OS cancer cells We performed whole exome sequencing 13 tumors, with matched lung metastases and normal tissues. Phylogenetic analyses revealed metastatic tumors often harbor clones are nonexistent or rare in tumors. Spatially temporally separated were from parallel seeding events polyphyletic pattern. Loss TP53 RB1 among early during...
Aiming at the crucial engineering challenge of ambiguous excavation deformation mechanism hard and brittle surrounding rock under high geos-tress conditions, with right bank diversion tunnel dam site hydropower station as research object, failure characteristics their formation mechanisms during layered were investigated. The findings show: (1) main factors influencing tunnel's are ground stress environment, degree fracture development in mass, effectiveness support system. (2) Following...
Deformable image registration (DIR) is a critical technic in adaptive radiotherapy (ART) for propagating contours between planning computerized tomography (CT) images and treatment CT/cone-beam CT (CBCT) to account organ deformation re-planning. To validate the ability accuracy of DIR algorithms at risk (OAR) contour mapping, ten intensity-based strategies, which were classified into four categories-optical flow-based, demons-based, level-set-based spline-based-were tested on fractional CBCT...
Objective. The study aims to establish and validate an effective CT-based radiation pneumonitis (RP) prediction model using the multiomics method of radiomics EQD2-based dosiomics. Materials Methods. performed a retrospective analysis on 91 nonsmall cell lung cancer patients who received radiotherapy from 2019 2021 in our hospital. with RP grade ≥1 were labeled as 1, those < 1 0. whole excluding clinical target volume (lung-CTV) was used region interest (ROI). radiomic dosiomic features...
Hypercapnic acidosis (HCA) has protective effects in animal models of acute lung injury, but the mechanism underlying effect HCA is unclear. Heme oxygenase-1 (HO-1) an antioxidant enzyme that protects tissue from inflammation injury. We investigated whether HO-1 contributes to ischemia-reperfusion (IR)-induced Typical injury rats was successfully induced by 40 min ischemia and 90 reperfusion isolated perfused model. The rat lungs were randomly assigned control group, IR group or + with...
Although ischemia-reperfusion injury is a major determinant of primary graft dysfunction after lung transplantation, an approach to extend preoperative preservation postoperative protection has not yet been defined. The purpose this study was determine the protective effects and signal pathway regulated by hypercapnic acidosis in ischemia-reperfusion-induced injury.Animal study.Animal care facility procedure room medical center.Adult male Sprague-Dawley rats.Lung induced clinically relevant...
Photosynthesis is the key physiological activity in process of crop growth and plays an irreplaceable role carbon assimilation yield formation. This study extracted rice (Oryza sativa L.) canopy reflectance based on UAV multispectral images analyzed correlation between 25 vegetation indices (VIs), three textural (TIs), net photosynthetic rate (Pn) at different stages. Linear regression (LR), support vector (SVR), gradient boosting decision tree (GBDT), random forest (RF), multilayer...
Emerging evidence reveals that nicotinamide phosphoribosyltransferase (NAMPT) has a significant role in the pathophysiology of inflammatory process. NAMPT inhibition beneficial effect treatment variety diseases. However, it remains unclear whether an impact on ischemia-reperfusion (I/R)-induced acute lung injury. In this study, we examined provided protection against I/R injury rats.Isolated perfused rat lungs were subjected to 40 min ischemia followed by 60 reperfusion. The rats randomly...