A5102840782- Cancer Immunotherapy and Biomarkers
- Analytical Methods in Pharmaceuticals
- Aquaculture disease management and microbiota
- Mercury impact and mitigation studies
- Antibiotics Pharmacokinetics and Efficacy
- Immune cells in cancer
- Renal Transplantation Outcomes and Treatments
- Analytical chemistry methods development
- Pancreatic and Hepatic Oncology Research
- Epilepsy research and treatment
- Mass Spectrometry Techniques and Applications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Analytical Chemistry and Chromatography
- Aquaculture Nutrition and Growth
- Environmental Toxicology and Ecotoxicology
- CAR-T cell therapy research
- Carbon Nanotubes in Composites
- S100 Proteins and Annexins
- Plant-based Medicinal Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Nanomaterials in Catalysis
- Mechanical and Optical Resonators
- Protein Hydrolysis and Bioactive Peptides
- Chemical Synthesis and Analysis
- Antimicrobial Peptides and Activities
Beijing University of Chemical Technology
2025
Beijing Friendship Hospital
2021-2024
Capital Medical University
2021-2024
Northwestern Polytechnical University
2024
Chinese PLA General Hospital
2024
China Pharmaceutical University
2004-2023
Zhejiang University
2019-2023
Daqing Oilfield General Hospital
2023
Jilin Agricultural University
2020-2022
Shanxi Agricultural University
2022
Abstract Ischemic stroke is a refractory disease that endangers human health and safety owing to cerebral ischemia. Brain ischemia induces series of inflammatory reactions. Neutrophils migrate from the circulatory system site accumulate in large numbers at inflammation across blood–brain barrier. Therefore, hitchhiking on neutrophils deliver drugs ischemic brain sites could be an optimal strategy. Since surface has formyl peptide receptor (FPR), this work modifies nanoplatform by...
Abstract Traumatic brain injuries (TBI) and stroke are major causes of morbidity mortality in both developing developed countries. The complex heterogeneous pathophysiology TBI cerebral ischemia‐reperfusion injury (CIRI), addition to the blood‐brain barrier (BBB) resistance, is a advancement diagnostics therapeutics. Clinical data showed that severity positively correlated with number neutrophils peripheral blood sites. Furthermore, neutrophil extracellular traps (NETs) released by correlate...
Abstract Paxlovid, a copackaged medication of nirmatrelvir tablets (150 mg) and ritonavir (100 developed by Pfizer, is one the first orally accessible COVID‐19 antiviral medicines to be approved for emergency usage. In this research, an efficient LC–MS/MS method simultaneous determination in human plasma was established validated with remdesivir as internal standard. Chromatographic separations were carried out on Thermo BDS Hypersil C18 column (4.6 × 100 mm, 2.4 μm) using deionized water...
The tumor microenvironment (TME) influences the occurrence and progression of tumors, hypoxia is an important characteristic TME. expression programmed death 1 (PD1)/programmed death-ligand (PDL1), cytotoxic T-lymphocyte-associated antigen 4 (CTLA4), other immune checkpoints in hypoxic malignant tumors often significantly increased, associated with poor prognosis. application checkpoint inhibitors (ICIs) for treating lung cancer, urothelial carcinoma, gynecological has achieved encouraging...
Lung cancer has the highest incidence and mortality rate worldwide. Immunotherapy is a universal treatment for lung cancer, but its overall remains challenge. Tumor immunoediting process in which immune system restricts or promotes tumor development through elimination, equilibrium, escape to change immunogenicity obtain an immunosuppressive mechanism promote disease progression. An increasing number of immunotherapy drugs, including monoclonal antibody-targeting drugs chimeric antigen (Ag)...
Glycosphingolipids (GSLs) are abundantly expressed in cancer cells. The effects of GSL-targeted immunotherapies not fully understood. Here, we show that the inhibition GSL synthesis with UDP-glucose ceramide glucosyltransferase inhibitor eliglustat can increase exposure major histocompatibility complex (MHC) and tumour antigen peptides, enhancing antitumour response CD8+ T cells a range models. We therefore conducted proof-of-concept phase I trial on combination an anti-PD-1 antibody for...
Fluoride-containing groundwater has become a major concern since it serves as source of drinking water for over half the world's population. Here, we develop an ion-selective polymeraldine salt (PANI-Clx; PANI = polyaniline) modulated Ti3C2Tx MXene electrode mediator electrochemical capture fluoride ion (F-) from groundwater. The single-stage configuration equipped with PANI-Clx/Ti3C2Tx anode and activated carbon cathode exhibits ultrafast removal rate 4.7 mg-F- g-1 min-1 toward F- high...
The aim of this study was to screen synergistic substances included in existing artificial feeds order improve the fertility and survival rate Harmonia axyridis, an efficient pest predator. To end, we analyzed potential effects glucose trehalose on growth, development, reproduction H. axyridis evaluated effect three different energy stress axyridis. contained fresh pork liver, honey, sucrose, vitamin C, royal jelly. Diet 2 3 trehalose, respectively. results showed that development were...
Fish is favored by consumers, while amino acids and fatty are the main nutrients of muscle. At present, it has been found that gut microbial community may be involved in regulation host material anabolism. Juvenile adult bighead carp (A. nobilis) from Chagan lake Xinlicheng reservoir were selected, divided into four groups to compare differences communities, free acid muscle.The results showed fish different lakes or ages contained specific microbiota, structure was similar, but content...
Nanodiamonds (NDs) are emerging as a promising platform for theranostic particles since they offer single that possesses multiple important properties. These include simple mechanism of synthesis, small size, chemical inertness, variety available surface functional groups, good biocompatibility, stable fluorescence, and long fluorescence lifetime. The use NDs to deliver anticancer drugs has been an ND application can increase chemosensitivity, sustain drug release, minimize side effects....
Pancreatic cancer (PC) is an aggressive with a high mortality rate, necessitating the development of effective diagnostic, prognostic and predictive biomarkers for disease management. Aberrantly fucosylated proteins in PC are considered valuable resource clinically useful biomarkers. The main objective present study was to identify novel plasma glycobiomarkers using iTRAQ quantitative proteomics approach coupled Aleuria aurantia lectin (AAL)-based glycopeptide enrichment isotope-coded...
Extracellular vesicles (EVs) are valuable sources for the discovery of useful cancer biomarkers. This study explores potential usefulness tumor cell-derived EV membrane proteins as plasma biomarkers early detection colorectal (CRC). EVs were isolated from culture supernatants four CRC cell lines by ultracentrifugation, and their protein profiles analyzed LC-MS/MS. Bioinformatics analysis identified revealed 518 in common among at least three lines. We next used accurate inclusion mass...
This study aimed to evaluate whether inosine enhances the efficacy of immune-checkpoint inhibitors in human malignant solid tumors.
A sensitive, simple, and specific liquid chromatographic method coupled with electrospray ionization-mass spectrometry for the determination of donepezil in plasma is developed, its pharmacokinetics healthy, male, Chinese studied. Using loratadine as internal standard, after extraction alkalized by isopropyl alcohol-n-hexane (3:97, v/v), solutes are separated on a C18 column mobile phase methanol-acetate buffer (pH 4.0) (80:20, v/v). Detection performed time-offlight mass spectrometer...