A5019822533- Lipoproteins and Cardiovascular Health
- Blood Pressure and Hypertension Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Ovarian cancer diagnosis and treatment
- Cancer Immunotherapy and Biomarkers
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Health and Risk Factors
- Cancer, Hypoxia, and Metabolism
- Air Quality and Health Impacts
- Antiplatelet Therapy and Cardiovascular Diseases
- Pharmaceutical Economics and Policy
- Cardiovascular Health and Disease Prevention
- Climate Change and Health Impacts
- Circular RNAs in diseases
- Acute Myocardial Infarction Research
- Traumatic Brain Injury Research
- Health disparities and outcomes
- Cancer, Lipids, and Metabolism
- PARP inhibition in cancer therapy
- MicroRNA in disease regulation
- EEG and Brain-Computer Interfaces
- Genetic Associations and Epidemiology
- Traumatic Brain Injury and Neurovascular Disturbances
- Infectious Aortic and Vascular Conditions
- Advancements in Transdermal Drug Delivery
China-Japan Friendship Hospital
2024
Capital Medical University
2013-2023
Beijing Anzhen Hospital
2012-2023
Beijing Friendship Hospital
2019-2022
Beijing Obstetrics and Gynecology Hospital
2020
Beijing Institute of Water
2013-2018
Ministry of Education of the People's Republic of China
2018
Columbia University
2014-2017
Tulane University
2014-2017
Columbia University Irving Medical Center
2014-2017
Background Hypertension is China's leading cardiovascular disease risk factor. Improved hypertension control in China would result enormous health gains the world's largest population. A computer simulation model projected cost-effectiveness of treatment Chinese adults, assuming a range essential medicines list drug costs. Methods and Findings The Cardiovascular Disease Policy Model-China, Markov-style model, simulated screening, program implementation, administration, monitoring costs,...
Outdoor air pollution ranks fourth among preventable causes of China's burden disease. We hypothesized that the magnitude health gains from quality improvement in urban China could compare with achieving recommended blood pressure or smoking control goals.The Cardiovascular Disease Policy Model-China projected coronary heart disease, stroke, and all-cause deaths Chinese adults 35 to 84 years age 2017 2030 if recent (particulate matter aerodynamic diameter ≤2.5 µm, PM2.5) traditional...
The tumor microenvironment (TME) influences the occurrence and progression of tumors, hypoxia is an important characteristic TME. expression programmed death 1 (PD1)/programmed death-ligand (PDL1), cytotoxic T-lymphocyte-associated antigen 4 (CTLA4), other immune checkpoints in hypoxic malignant tumors often significantly increased, associated with poor prognosis. application checkpoint inhibitors (ICIs) for treating lung cancer, urothelial carcinoma, gynecological has achieved encouraging...
Background— The cost-effectiveness of the optimal use hospital-based acute myocardial infarction (AMI) treatments and their potential impact on coronary heart disease (CHD) mortality in China is not well known. Methods Results— effectiveness costs AMI were estimated by CHD Policy Model-China, a Markov-style computer simulation model. Changes simulated AMI, mortality, quality-adjusted life years, total healthcare outcomes. incremental ratio was used to assess projected cost-effectiveness....
The aim of our study was to investigate the therapeutic effect Mesenchymal stem cell-derived exosomes (MSC-exs) on eczema mice model.Eczema were established by 2, 4-two nitrochlorobenzene. Human umbilical cords cells and harvested. In model, MSC-ex evaluated severity score, atopic dermatitis score histopathological analysis dermis. MTT tests performed assess PBMC proliferation. Treg identified flow cytometry. angiogenesis analyzed endothelial cell tube formation assay.Compared with PBS,...
Although important progress has been made in understanding Lp(a) (lipoprotein[a])-mediated stroke risk, the contribution of to progression vulnerable plaque features associated with risk remains unclear. This study aims evaluate whether is carotid progression, new-onset features, and vulnerability a prospective community-based cohort study.Baseline levels were measured using latex-enhanced turbidimetric immunoassay among 804 participants aged 45 74 years free cardiovascular disease Chinese...
Aim: The lipoprotein-associated phospholipase A2(Lp-PLA2) level has been shown to be associated with the risk of clinical cardiovascular events. We aimed investigate whether Lp-PLA2 is progression subclinical atherosclerosis in general population. Methods: degree carotid plaque and maximal intima-media thickness(IMT) were measured twice over a 5-year interval 913 participants 45 74 years age at baseline cohort study. associations between plasma activity changes IMT assessed according sex...
The aims of the present study were to investigate clinical outcomes and safety apatinib monotherapy in treatment patients with advanced epithelial ovarian carcinoma (EOC) who have progressed after standard regimens, analyze vascular endothelial growth factor receptor 2 (VEGFR2) rs2071559 polymorphism. A total 118 EOC received included study. Tumor response was evaluated using progression-free survival (PFS) overall (OS) time, data documented. Additionally, peripheral blood mononuclear cell...
No indices are currently available to facilitate clinicians identify patients who need either statin monotherapy or statin-ezetimibe combined treatment. We aimed investigate whether cholesterol synthesis and absorption markers can predict the cholesterol-lowering response statin. Total 306 statin-naïve with high risk of coronary heart disease (CHD) were treated atorvastatin 20 mg/day for 1 month. Cholesterol LDL (LDL-C) levels measured before after Atorvastatin decreased LDL-C by 36.8%...
Abstract Background The availability of physical activity (PA) facilities in neighborhoods is hypothesized to influence cardiovascular disease (CVD), but evidence from individual-level long-term cohort studies limited. We aimed assess the association between neighborhood exposure PA and CVD incidence. Methods A total 4658 participants Chinese Multi-provincial Cohort Study without at baseline (2007–2008) were followed for incidence CVD, coronary heart (CHD), stroke. Availability was defined...
The combination of immune-checkpoint blockade (ICB) and lenvatinib has demonstrated robust clinical effects that are superior to those monotherapies, but the synergistic anti-tumor mechanisms remain unclear. Exploring molecular early identifying potential application have key importance for therapeutics. We firstly systematically reviewed published data ICB in with treatment cancer by meta-analysis. A subsequent bioinformatics analysis explored mechanism combined therapy 33 types....
<strong>Background:</strong> Statin medications reduce the risk of atherosclerotic cardiovascular disease (ASCVD). China's new central government medicine procurement policy lowered statin prices by five-fold or more, which may impact cost-effectiveness therapy. <strong>Objective:</strong> To explore 2019 centralized on statins treatment for primary ASCVD prevention. <strong>Methods:</strong> A microsimulation decision tree analytic model was built using individual participant data from...
Abstract Objective To investigate the diagnostic utility of fine needle aspiration ( FNA ) smear, cell block CB ), flow cytometry FC and tuberculosis polymerase chain reaction (Tb‐ PCR analysis for Kikuchi's disease KD ). Methods A total 173 biopsy samples were collected using a Youyi aspirator. was diagnosed by with or without, , Tb‐ . Results Out patients, 131 (75.7%) female 126 (72.8%) aged 21‐40 years. Of these, 171 patients (98.8%) presented painful enlarged cervical lymph nodes. All...
Objectives:This study aimed to conduct and assess a module modified acute physiology chronic health evaluation (MM-APACHE) II model, based on disease categories modified-acute (DCM-APACHE) in predicting mortality more accurately neuro-intensive care units (N-ICUs).Methods:In total, 1686 patients entered into this prospective study. Acute (APACHE) scores of all admission worst 24-, 48-, 72-hour were obtained. Neurological diagnosis was classified five categories: cerebral infarction,...
To assess overall and gender-specific associations between marital status out-of-hospital coronary death (OHCD) compared with patients surviving to hospital admission. A cross-sectional study based on linkage of administrative health databases. Beijing, China. From 2007 2019, 378 883 acute event were identified in the Beijing Monitoring System for Cardiovascular Diseases, a validated city-wide registration system individual vital discharge data. OHCD was defined as occurring before...
Background The eradication regimen for Helicobacter pylori ( H. ) infection can induce gut dysbiosis. In this open-label, prospective, and randomized clinical trial, we aimed to assess the effects of fucoidan supplementation on rate microbial homeostasis in context quadruple therapy, as well investigate combined synbiotics supplementations. Methods Eighty patients with were enrolled randomly assigned one four treatment groups: QT (a 2-week therapy alone), QF (quadruple plus a 6-week...