A5102919988- Pregnancy and preeclampsia studies
- Antioxidant Activity and Oxidative Stress
- Atherosclerosis and Cardiovascular Diseases
- Cancer-related molecular mechanisms research
- Birth, Development, and Health
- Circular RNAs in diseases
- Lipoproteins and Cardiovascular Health
- Gestational Diabetes Research and Management
- Maternal Mental Health During Pregnancy and Postpartum
- Cancer Treatment and Pharmacology
- COVID-19 Impact on Reproduction
- Thyroid Disorders and Treatments
- Cancer, Lipids, and Metabolism
- Cardiovascular Health and Risk Factors
- RNA modifications and cancer
- Prostate Cancer Treatment and Research
- Ovarian cancer diagnosis and treatment
- Electromagnetic Fields and Biological Effects
- HER2/EGFR in Cancer Research
- Bariatric Surgery and Outcomes
- Eicosanoids and Hypertension Pharmacology
- Galectins and Cancer Biology
- Endometrial and Cervical Cancer Treatments
- Free Radicals and Antioxidants
- Cancer-related gene regulation
Beijing Chaoyang Emergency Medical Center
2025
Beijing Obstetrics and Gynecology Hospital
2021-2025
Capital Medical University
2015-2025
Second Military Medical University
2013-2022
Changhai Hospital
2022
Tianjin Medical University
2020
Second Hospital of Tianjin Medical University
2020
Union Hospital
2019
Jilin University
2015-2019
Beijing Anzhen Hospital
2015-2018
The China birth cohort study (CBCS) is a prospective longitudinal, mega-cohort and the first national-based study, aiming to establish covering representative geographical areas of whole investigate risk factors for defects develop strategies their reduction. Pregnant women who are Chinese nationality, 6-13+6 weeks gestation, plan attend routine antenatal examination deliver in site, give informed, written consent eligible participate this study. All participants followed-up through an...
Abstract Background Subclinical hypothyroidism (SCH) is linked to dyslipidaemia and adverse pregnancy outcomes. However, the impact of on outcome in SCH unclear. Methods We enrolled 36,256 pregnant women evaluated their The following data was gathered during first trimester (≤ 13 + 6 weeks gestation): total cholesterol (TC), low-density lipoprotein (LDL-C), triglyceride (TG), high-density (HDL-C), free thyroxine (FT4) thyroid-stimulating hormone (TSH) concentrations. reference ranges for...
Chemoresistance remains a significant challenge in chronic myelogenous leukemia (CML) management, which is one of the most critical prognostic factors. Elucidation molecular mechanisms underlying resistance to chemoresistance may lead better clinical outcomes.In order identify potential protein targets involved drug-resistant phenotype leukemia, especially (CML), we used high-resolution "ultra-zoom" 2DE-based proteomics approach characterize global expression patterns doxorubicin-resistant...
Background: The relationship between maternal thyroid-stimulating hormone (TSH), free thyroxine (FT4) and thyroid peroxidase antibody (TPOAb) status hypertensive disorders of pregnancy (HDP) remains uncertain. Methods: This was a prospective cohort study based on the China Birth Cohort Study (CBCS). 36,256 women were included at 6 to 13+6 gestation from February 2018 December 2020. Generalized linear mixed models used investigate association function HDP/BP. We further performed multiple...
Second-generation androgen receptor (AR) inhibitors such as enzalutamide are the first-line treatments for castration-resistant prostate cancer (CRPC). Resistance to will greatly increase difficulty of treatment and reduce survival time patients. However, drug-resistant cells seem be more sensitive ferroptosis. Therefore, we constructed a biomimetic tumor-targeting magnetic lipid nanoparticle (t-ML) codeliver dihomo-γ-linolenic acid (DGLA) 2,4-dienoyl-CoA reductase 1 (DECR1) siRNA...
To investigate the association between circulating oxidized low-density lipoprotein (ox-LDL) levels and progression of subclinical atherosclerosis to examine whether this link is independent other (LDL)-related parameters.Totally, 804 subjects who were free cardiovascular disease at baseline completed risk factor surveys carotid ultrasound measurements in 2002 2012. Modified Poisson regression was performed serum ox-LDL 10-year which defined as development least one new plaque a previously...
The coronavirus disease 2019 (COVID-19) pandemic has caused far-reaching changes in all areas of society. However, limited data have focused on the long-term impacts perinatal psychological health. This study aims to evaluate COVID-19 crisis health among women and investigate associated factors.
Abstract This study aimed to explore the role of transcription factor 12 (TCF12) in process gastric cancer (GC) and elucidate its possible regulatory mechanism. The expression data GC tissues matched normal were downloaded from Cancer Genome Atlas (TCGA) database. Survival analysis for patients with different levels TCF12 was performed by Kaplan‐Meier analysis. In addition, suppressed human cell lines AGS MKN‐45, followed detecting biological processes (proliferation, apoptosis, migration,...
The molecular mechanism that controls the proliferation and differentiation of prostate epithelial cells is currently unknown. We previously identified a 44-kDa protein (p44/wdr77) as an androgen receptor-interacting regulates set receptor target genes in cancer. In this study, we found p44 localizes cytoplasm at early stage development when are proliferating, its nuclear translocation associated with cellular functional adult tissue. further demonstrated cytoplasmic essential for cells,...
To determine whether gestational cardiovascular health (CVH) during the first trimester is associated with a risk of adverse pregnancy outcomes.
The androgen receptor (AR) pathway plays critical roles in controlling differentiation and proliferation of prostate epithelial cells. We previously identified a novel AR cofactor, p44/WDR77, which specifically enhances transcriptional activity the gland cancer. To further elucidate p44/WDR77's role signaling pathway, we conducted yeast two-hybrid screening cGMP-dependent protein kinase (PKG) as p44/WDR77-interacting protein. Further investigation by lusiferase assay demonstrated that PKG-Iβ...
Background The heterogeneity of oral glucose tolerance test (OGTT) patterns during pregnancy remains unclear. This study aims to identify latent OGTT in pregnant women and investigate the high-risk population for late-onset gestational diabetes mellitus (GDM).
Background: Bladder cancer (BC) is the 10th most common worldwide with significantly varied prognosis in different pathological subtypes. MMPs, a group of enzymes, could involve invasion and metastasis numerous malignancies. The function MMPs BC partly reported several studies but great conflicts; hence, systematic analysis expression levels prognostic values these MMP genes are still to be determined. Methods: Firstly, differentially expressed (DEGs) were identified ONCOMINE, GEPIA UALCAN...