A5045655860- Parasites and Host Interactions
- Trace Elements in Health
- Parasite Biology and Host Interactions
- Helminth infection and control
- Drug Transport and Resistance Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Liver Disease and Transplantation
- Parasitic Infections and Diagnostics
- Liver physiology and pathology
- Hepatitis B Virus Studies
- Neurological diseases and metabolism
- Atherosclerosis and Cardiovascular Diseases
- Mitochondrial Function and Pathology
- Immunotherapy and Immune Responses
- Oral and gingival health research
- Amoebic Infections and Treatments
- RNA modifications and cancer
- Immune Response and Inflammation
- Metabolism and Genetic Disorders
- Parasitic infections in humans and animals
- Cholesterol and Lipid Metabolism
- Liver Diseases and Immunity
- Parasitic Diseases Research and Treatment
- Renal cell carcinoma treatment
- Invertebrate Immune Response Mechanisms
Guangxi Medical University
2025
Sichuan Agricultural University
2025
Guangxi University of Chinese Medicine
2025
Guangxi University
2025
Chengdu University of Traditional Chinese Medicine
2024
Research Institute of Petroleum Exploration and Development
2024
Sun Yat-sen University
2013-2023
Wuhan University
2023
Renmin Hospital of Wuhan University
2023
Chinese PLA General Hospital
2021
Clonorchis sinensis is a carcinogenic human liver fluke that widespread in Asian countries. Increasing infection rates of this neglected tropical disease are leading to negative economic and public health consequences affected regions. Experimental epidemiological studies have shown strong association between the incidence cholangiocarcinoma rate C. sinensis. To aid research into organism, we sequenced its genome.We combined de novo sequencing with computational techniques provide new...
Clonorchis sinensis (C. sinensis), an important food-borne parasite that inhabits the intrahepatic bile duct and causes clonorchiasis, is of interest to both public health field scientific research community. To learn more about migration, parasitism pathogenesis C. at molecular level, present study developed upgraded genomic assembly annotation by sequencing paired-end mate-paired libraries. We also performed transcriptome sequence analyses on multiple tissues (sucker, muscle, ovary...
Dengue hemorrhagic fever and/or dengue shock syndrome represent the most serious pathophysiological manifestations of human virus infection. Despite intensive research, mechanisms and important cellular players that contribute to disease are unclear. Mast cells tissue-resident innate immune play a sentinel cell role in host protection against infectious agents via pathogen-recognition receptors by producing potent mediators modulate inflammation, recruitment normal vascular homeostasis. Most...
COX20-related mitochondrial complex IV deficiency is a rare autosomal recessive metabolic disorder that arises from biallelic loss-of-function mutations. Given the lack of specific treatments, affected children are at heightened risk disability. Consequently, prenatal counseling and diagnosis should be conducted to reduce birth rate with such diseases. We report case COX20 gene associated in child, describe mother subsequent pregnancies provide reference for this disease. In study, we...
Plant elicitors have emerged as key agents in effectively invoking immune responses across various plant species, gaining attention for their role sustainable agricultural protection strategies. However, the economic utility of peptide such flg22, flgII-28, and systemin is limited when considering broader applications. This study introduces a novel recombinant protein, SlRP5, which integrates five active epitopes—flg22, csp22, SIPIP1, systemin—to activate significantly enhance resistance to...
Chronic infection with Clonorchis sinensis (C.sinensis) has been associated swith the development of intrahepatic cholangiocarcinoma (ICC); however, relationship between C.sinensis and hepatocellular carcinoma (HCC) remains uncertain. This study examined 120 patients liver cancer in clonorchiasis endemic area Hengzhou, Guangxi, China. The type cancer, differentiation grade according to Edmondson Steiner's classification, pathological characteristics HCC were determined through postoperative...
Spermatids undergo the final steps of maturation during spermiogenesis, a process that necessitates extensive rearrangement organelles such as mitochondria. Male infertility has been linked to mitochondrial disorder, for example, hypospermatogenesis and asthenozoospermia. However, mechanisms regulate dynamics spermiogenesis remain largely unknown. We found glycerol kinase (Gyk)-like proteins kinase-like 1 (Gykl1) 2 (Gk2) were specifically localized mitochondria in spermatids. mice deficient...
Long-term infections by Clonorchis sinensis are associated with cholangitis, cholecystitis, liver fibrosis, cirrhosis, and even cancer. Molecules from the worm play vital roles in disease progress. In present study, we identified explored molecular characterization of C. granulin (CsGRN), a growth factor-like protein excretory/secretory products (CsESPs). The encoding sequence conserved domains CsGRN were analysed bioinformatics tools. Recombinant (rCsGRN) was expressed Escherichia coli BL21...
Background Clonorchis sinensis (C. sinensis) is considered to be an important parasitic zoonosis because it infects approximately 35 million people, while 15 were distributed in China. Hepatitis B virus (HBV) infection a major public health issue. Two types of pathogens have the potential cause human liver disease and eventually hepatocellular carcinoma. Concurrent with HBV C. often observed some areas where endemic. However, whether could impact or vice versa remains unknown. Principal...
Liver fluke proteins, including excretory-secretory products (ESPs) and tegument are critical for the pathogenesis, nutrient metabolism, etiology immune response of liver cancer. To understand functions various proteins in Clonorchis sinensis physiology human clonorchiasis, ESPs C. were identified. Supernatants containing from adult after culture 6 h harvested concentrated. The was detached using a freeze/thaw method successively extracted extraction buffers. outer surface labeled with...
Abstract Background Infections with the opisthorchid liver flukes Clonorchis sinensis , Opisthorchis viverrini and O. felineus cause severe health problems globally, particularly in Southeast Asia. Early identification of infection is essential to provide timely appropriate chemotherapy patients. Results In this study we evaluate a PCR-based molecular method, Multiplex Ligation-dependent Probe Amplification (MLPA), which allows rapid specific detection single nucleotide acid differences...
Background Clonorchiasis, caused by the infection of Clonorchis sinensis (C. sinensis), is a kind neglected tropical disease, but it highly related to cholangiocarcinoma and hepatocellular carcinoma (HCC). It has been well known that excretory/secretory products C. (CsESPs) play key roles in clonorchiasis associated carcinoma. From genome transcriptome sinensis, we identified one component CsESPs, severin (Csseverin), which had three putative gelsolin domains. Its homologues are supposed...
Clonorchis sinensis (C. sinensis, Cs) is a trematode parasite that often causes chronic cumulative infections in the hepatobiliary ducts of host and can lead to pathological changes by continuously released excretory/secretory proteins (ESPs). A T2 ribonuclease ESPs, has been identified as potent regulator dendritic cell (DCs) modulation. We wondered whether there was counterpart present Cs ESPs with similar activity. To gain better understanding associated immune responses, we characterized...