A5033490228- Parasites and Host Interactions
- Hepatitis B Virus Studies
- Drug-Induced Hepatotoxicity and Protection
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Neonatal Respiratory Health Research
- Liver Disease and Transplantation
- Parasite Biology and Host Interactions
- Drug Transport and Resistance Mechanisms
- Neonatal Health and Biochemistry
- Parasitic Diseases Research and Treatment
- Preterm Birth and Chorioamnionitis
- Liver Disease Diagnosis and Treatment
- Neonatal and fetal brain pathology
- Osteomyelitis and Bone Disorders Research
- Antifungal resistance and susceptibility
- Viral-associated cancers and disorders
- Metabolism and Genetic Disorders
- Renal and related cancers
- Myasthenia Gravis and Thymoma
- Sexual Differentiation and Disorders
- Neonatal and Maternal Infections
- Sinusitis and nasal conditions
- Immune responses and vaccinations
- Thermal Regulation in Medicine
Sun Yat-sen University
2016-2025
Third Affiliated Hospital of Sun Yat-sen University
2016-2025
Third Affiliated Hospital of Zhengzhou University
2019-2021
First Hospital of Shijiazhuang
2018
University of Delaware
2012-2013
Southern Medical University
2010
Background Given the limited effective treatments for Alzheimer's disease (AD), obesity and serum uric acid (SUA) levels which are considered modifiable risk factors dementia of interest. However, research indicates conflicting results. Objective We aimed to further investigate association body weight (BW) SUA with AD biomarkers cognitive impairment. Methods Clinical data were collected from 139 adults (mean age 66.9 years) chronic Cerebrospinal fluid (CSF) PET imaging used assess amyloid-β...
Background Clonorchis sinensis (C. sinensis) is considered to be an important parasitic zoonosis because it infects approximately 35 million people, while 15 were distributed in China. Hepatitis B virus (HBV) infection a major public health issue. Two types of pathogens have the potential cause human liver disease and eventually hepatocellular carcinoma. Concurrent with HBV C. often observed some areas where endemic. However, whether could impact or vice versa remains unknown. Principal...
The relationship between severe anemia, red blood cell transfusion and Neonatal necrotizing enterocolitis (NEC) remains controversial. purpose of this study was to determine the association anemia RBC with NEC in neonates.The clinical characteristics were observed 467 infants different birth weights from January 2012 July 2020. A 1:1 ratio case-control performed very low weight (VLBW) infants. Severe transfusion, confounding factors, including maternal perinatal complications, feeding,...
BackgroundWe aimed to determine the predictive neurological prognostic value of early amplitude-integrated electroencephalography (aEEG) in term and near-term neonates with severe hyperbilirubinemia compared cranial magnetic resonance imaging (MRI) auditory brainstem response (ABR).MethodsInfants ≥35 weeks gestation (total serum bilirubin [TSB] ≥340 μmol/L) or (TSB ≥257 association bilirubin-induced dysfunction were recruited. All subjects had an aEEG after being admitted neonatal intensive...
In China, people infected with hepatitis B virus (HBV) are commonly found in areas a high prevalence of Clonorchis sinensis, trematode worm. Published studies have reported that the progression is affected by coinfection C. sinensis.Clinical data from total 72 patients sinensis and HBV (as sole infection or coinfections) 29 healthy individuals were analysed. We also incubated hepatic stellate cell line LX-2 proteins adult worms (CsTPs) HBV-positive sera. addition, human hepatoblastoma...
Chronic liver inflammation caused by chronic hepatitis B virus (CHB) infection leads to cirrhosis and hepatocellular carcinoma. Recently, the role of alanine aminotransferase (ALT) as a predictor has been questioned. The aim this study was investigate utility noninvasive fibrosis markers including hyaluronic acid (HA), collagen type IV (CIV), N‐terminal propeptide III procollagen (PIIINP), laminin (LN) in identifying significant patients with CHB, especially normal or near‐normal ALT. A...
To determine the efficacy and prognostic value of amplitude-integrated electroencephalography (aEEG) in term near-term neonates with high risk neurological sequelae.Infants ≥35 weeks gestation diagnosed neonatal encephalopathy or brain injury were included. All eligible infants underwent aEEG within 6 h after clinical assessment. The followed up 12 months to evaluate development.A total 250 eligible, which 85 had normal aEEG, 81 mildly abnormal 84 severely aEEG. Of these infants, 168...
Marek's disease (MD) is a highly transmissible, herpesvirus-associated malignancy of chickens and turkeys caused by virus (MDV). MD currently controlled through the use nonsterilizing vaccines composed antigenically related, apathogenic herpesviruses Mardivirus 2 (MDV-2), Meleagrid herpesvirus 1 (herpesvirus turkeys, HVT), or attenuated MDV-1 strain CVI988 (Rispens). Since mid-1960s, field strains MDV have increased in virulence, due, part, to widespread since early 1970s. One mutation that...
Marek's disease (MD) is a highly contagious viral of chickens (Gallus gallus domesticus) caused by MD virus (MDV), characterized paralysis, neurologic signs, and the rapid onset T-cell lymphomas. MDV-induced transformation requires basic leucine zipper protein called EcoRI-Q–encoded (Meq). We have identified mutations in coding sequence Meq that correlated with pathotype (virulent, very virulent, virulent plus). The aim this study was to determine whether recombinant viruses could be...
Clonorchis sinensis, the causative agent of clonorchiasis, is classified as one most neglected tropical diseases and affects more than 15 million people globally. This hepatobiliary disease highly associated with cholangiocarcinoma. As key molecules in infectivity subsistence trematodes, glycolytic enzymes have been targets for drug vaccine development. sinensis pyruvate kinase (CsPK), a crucial enzyme, was characterized this research. Differences were observed sequences spatial structures...
The aim of this study was to produce monoclonal and polyclonal antibodies against procalcitonin (PCT), a valid post-mortem marker sepsis marker. Monoclonal (MAbs) were made from hyperimmune Balb/c mice by injecting 50 microg purified antigen. These immunized four times given final boost, their spleen cells collected fused with SP2/0 myeloma under the presence PEG 1450. Hybridomas screened indirect enzyme-linked immunosorbent assay (ELISA) using protein. Lastly, five MAbs obtained designated...
Background Serum 25-hydroxyvitamin D level is associated with erectile dysfunction (ED) in observational studies. However, whether there a causal association between them remains uncertain. Objective Conduct two-sample Mendelian randomization (MR) analysis to investigate the effect serum and ED risk. Method Genome-wide study (GWAS) data of levels comprising 6,896,093 single nucleotide polymorphisms (SNP) from 496,949 people European ancestry were regarded as exposure for MR analysis....
<title>Abstract</title> An in vivo mouse model of <italic>Clonorchis sinensis</italic> (<italic>C. sinensis</italic>) infection with or without the administration autophagy inhibitor chloroquine (CQ) stimulation was established to assess possible involvement autophagic response during <italic>C. infection. Abnormal liver function observed at four, six, eight weeks post-infection, as indicated by elevated levels ALT/GPT, AST/GOT, TBIL, α-SMA infected group. Our findings activated autophagy,...
Abstract Soluble Intercellular Adhesion Molecule-1 (sICAM-1) has emerged as an inflammatory biomarker of many essential functions. We investigated the level sICAM-1 influenced by Clonorchis sinensis ( C. ) co-infection in chronic hepatitis B (CHB) patients to explore degree liver tissue inflammation and function damage after co-infection. The study included data from with mono-infection (n=27), virus (HBV) (n=32), HBV (n=24), post-hepatitis cirrhosis (n=18), co-infected (n=16), healthy...
We evaluated the levels of sex hormones in male hepatitis B patients co-infected with Clonorchis sinensis (C. sinensis).A total 136 individuals were enrolled this study, including 27 healthy controls, 28 C. mono-infection, 19 only chronic B, 18 post-hepatitis liver cirrhosis, 26 sinensis, and cirrhosis coinfected sinensis. Serum progesterone (P), luteinizing hormone (LH), estradiol (E2), testosterone (T), prolactin (PRL), follicle stimulating (FSH) these groups measured.The results showed...
Abstract Background Co-infection with Clonorchis sine nsis ( C. sinensis ) and Hepatitis B virus (HBV) are commonly observed in endemic areas of Clonorchiasis. Our previous analysis demonstrated that HBV coinfection could affect Th1/Th2 cytokines production infection might aggravate the disease state infection. The immune mechanisms related to pathogenesis co-infection worthy investigation. Methods Myeloid-derived suppressor cells (MDSCs) associated chronic inflammation. Dendritic (DCs) key...