A5101537313- Chronic Kidney Disease and Diabetes
- Advanced Glycation End Products research
- Diet and metabolism studies
- Autophagy in Disease and Therapy
- Renal Diseases and Glomerulopathies
- Neonatal Respiratory Health Research
- Nutrition and Health in Aging
- Neonatal Health and Biochemistry
- Pharmacology and Obesity Treatment
- Neonatal and fetal brain pathology
- Acute Ischemic Stroke Management
- Gut microbiota and health
- Heme Oxygenase-1 and Carbon Monoxide
- Traditional Chinese Medicine Analysis
- Sirtuins and Resveratrol in Medicine
- Tryptophan and brain disorders
- FOXO transcription factor regulation
- Lysosomal Storage Disorders Research
- Phytochemical compounds biological activities
- Simulation-Based Education in Healthcare
- Plant-derived Lignans Synthesis and Bioactivity
- Cytomegalovirus and herpesvirus research
- Meta-analysis and systematic reviews
- Nutritional Studies and Diet
- Retinopathy of Prematurity Studies
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Hebei Medical University
2018-2025
Second Hospital of Hebei Medical University
2018-2025
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2018-2023
Beijing University of Chinese Medicine
2019-2023
Ministry of Education of the People's Republic of China
2023
Xiangnan University
2023
First Affiliated Hospital of Heilongjiang University of Chinese Medicine
2023
Zhengzhou Children's Hospital
2012-2020
Chongqing Maternal and Child Health Hospital
2020
It has been reported that autophagic stress, which is involved in many diseases, plays a key role the development of diabetic nephropathy (DN). In this study, we investigated effects high dose vitamin E on renal tubular epithelial cells and stress-related mechanisms diabetes condition. rats, treatment significantly decreased serum creatinine, urea nitrogen, urinary albumin protein, reduced levels LCN2, HAVCR1, LDH 8-OHdG urine, attenuated cellular apoptosis interstitial fibrosis cortex....
Hypertensive renal injury is a complication of hypertension. Cordyceps cicadae (C. cicadae) traditional Chinese medicine used to treat chronic kidney diseases especially fibrosis. Autophagy described as cell self-renewal process that requires lysosomal degradation and utilized for the maintenance cellular energy homeostasis. The present study explores mechanism underlying C. cicadae's renoprotection on hypertensive nephropathy (HN). First, HN rat models were established spontaneously rats...
Abstract Background Ulcerative colitis (UC) is a chronic non-specific inflammatory disease of the colon. Infliximab or vedolizumab recommended for treatment moderate to severe UC, but has primary secondary non-response rate. Receiving early predictions on efficacy can offer substantial support patients’ therapeutic interventions. We aim use fecal bile acids identify predictive biomarkers. Methods Fecal samples were collected from 55 UC patients hospitalized in Second Hospital Hebei Medical...
In clinical practice, some patients diagnosed with anxiety disorder (AD) may develop bipolar (BD) many years later, and cases of AD be cured by the use mood stabilizers. However, relationship between BD should explored further. To track how turned to discover differences them, we recruited 48 BD, who were assigned group for retrospective analysis, also 186 at enrolment; this latter was asked complete follow-up surveys conducted 3 months, 6 12 months 18 after primary stage study. We defined...
Objective The reasons that physicians leave the institutions have not been extensively studied. We aimed to evaluate these reasons, which include desire work at another hospital or intention make a career change, among in tertiary hospitals China and explore associations between individual-level organizational-level factors related two for leaving. Methods conducted national survey of 136 across all 31 provinces December 2017 January 2018. A total 20 785 were selected self-report on...
Our previous study demonstrated that chronic intermittent hypobaric hypoxia (CIHH) can confer hepatic protection by reducing endoplasmic reticulum stress (ERS) in high-fat-high-fructose induced metabolic syndrome (MS) rats. It is known there a functional coupling between autophagy and ERS. This aimed to investigate the effect of CIHH on function adenosine mono-phosphate-activated protein kinase-mammalian target rapamycin (AMPKα-mTOR) signaling pathway tissue MS rats.6-week old male...
The objective of the present study was to evaluate 2-year effectiveness modified Shenzhuo formula in treatment overt proteinuria diabetic kidney disease (DKD). Patients diagnosed with type 2 DKD clinical research database Prof Xiaolin Tong (>20,000 data points) >1-year follow-up were screened for this study. Patients’ demographic data, chief complaint, illness, past history, allergic personal family test results, tongue images, pulse information, and prescription information at 1, 1.5, years...
Abstract Background Diabetic kidney disease (DKD) is a serious complication associated with diabetes mellitus and can cause end-stage renal (ESRD). Traditional Chinese medicine (TCM) widely used in China to treat DKD, particular microalbuminuria macroalbuminuria. This study will address the efficacy safety of Shenzhuo Formula (SZF), frequently prescribed TCM, DKD patients Methods/design 24-week, randomized, multi-center, double-blinded, double-dummy, controlled, clinical trial that include...
Although results from in vitro studies and small randomized controlled trials have shown positive effects of Dazhu hongjingtian injection (DZHJTI) on acute ischemic stroke (AIS), their generalizability to routine clinical practice remains be established.
Modified Da Chaihu decoction (MDCH) is a traditional Chinese herbal prescription that has been used in the clinic to treat type 2 diabetes (T2D). Previous studies have confirmed MDCH improves glycemic and lipid metabolism, enhances pancreatic function, alleviates insulin resistance patients with T2D diabetic rats. Evidence demonstrated protects β cells via regulating gene expression of sirtuin 1 (SIRT1) forkhead box protein O1 (FOXO1). However, detailed mechanism remains unclear....
To determine the efficacy and prognostic value of amplitude-integrated electroencephalography (aEEG) in term near-term neonates with high risk neurological sequelae.Infants ≥35 weeks gestation diagnosed neonatal encephalopathy or brain injury were included. All eligible infants underwent aEEG within 6 h after clinical assessment. The followed up 12 months to evaluate development.A total 250 eligible, which 85 had normal aEEG, 81 mildly abnormal 84 severely aEEG. Of these infants, 168...