A5000184677- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Systemic Sclerosis and Related Diseases
- Erythropoietin and Anemia Treatment
- Metabolomics and Mass Spectrometry Studies
- Alkaloids: synthesis and pharmacology
- Mitochondrial Function and Pathology
- Blood transfusion and management
- Vasculitis and related conditions
- Phytochemistry and biological activities of Ficus species
- Genetics, Aging, and Longevity in Model Organisms
- Genetic Syndromes and Imprinting
- Renal cell carcinoma treatment
- Berberine and alkaloids research
- Dietary Effects on Health
- Renin-Angiotensin System Studies
- Alcohol Consumption and Health Effects
- Traditional Chinese Medicine Studies
- Natural Compounds in Disease Treatment
- Medicinal Plants and Bioactive Compounds
- Nuclear Receptors and Signaling
- Pharmacogenetics and Drug Metabolism
- Acupuncture Treatment Research Studies
- Autophagy in Disease and Therapy
Zhejiang Chinese Medical University
2023-2025
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2021-2024
Beijing University of Chinese Medicine
2021-2024
Triptolide, a major active ingredient isolated from Tripterygium wilfordii Hook f., is effective in the treatment of membranous nephropathy (MN); however, its pharmacological mechanism action has not yet been clarified. We applied an approach that integrated network pharmacology and experimental validation to systemically reveal molecular triptolide MN.First, potential targets MN-related were collected publicly available database. Then, based on protein-protein interaction as well GO KEGG...
Hypertensive renal injury is a complication of hypertension. Cordyceps cicadae (C. cicadae) traditional Chinese medicine used to treat chronic kidney diseases especially fibrosis. Autophagy described as cell self-renewal process that requires lysosomal degradation and utilized for the maintenance cellular energy homeostasis. The present study explores mechanism underlying C. cicadae's renoprotection on hypertensive nephropathy (HN). First, HN rat models were established spontaneously rats...
Hypertensive nephropathy (HN), caused by long-term poorly controlled hypertension, is the second common cause of end-stage renal disease after diabetes mellitus, but pathogenesis HN unclear. The purpose this study was to identify biological pathways involved in progression and bile acid (BA)-related biomarkers, analyze role acids HN. Download gene microarray data from Gene Expression Omnibus. Differentially expressed genes (DEGs) associated with were identified, then DEGs subjected Ontology...
A risk association between membranous nephropathy (MN) and lung cancer is reported, but traditional observational studies cannot provide strong evidence of its causality. This study aimed to assess genome-wide data for a causal relationship MN using two-sample Mendelian randomization (MR) approach. Inverse-variance weighted, MR Egger regression techniques were used determine the genetic variants from cohorts patients. Independent with significance (P < 5×10-8) direction chance. Sensitivity...
Membranous nephropathy (MN) is an autoimmune glomerular disease that predominantly mediated by immune complex deposition and complement activation. The aim of this study was to identify key biomarkers MN investigate their association with immune-related mechanisms, inflammatory cytokines, chemokines chemokine receptors (CCRs).MN cohort microarray expression data were downloaded from the GEO database. Differentially expressed genes (DEGs) in identified, hub determined using a protein-protein...