A5100380846- Liver Disease Diagnosis and Treatment
- Traditional Chinese Medicine Studies
- Hepatitis B Virus Studies
- Hedgehog Signaling Pathway Studies
- Gastroesophageal reflux and treatments
- Viral-associated cancers and disorders
- Immune Response and Inflammation
- Heart Rate Variability and Autonomic Control
- Amino Acid Enzymes and Metabolism
- Cardiovascular Syncope and Autonomic Disorders
- S100 Proteins and Annexins
- Respiratory viral infections research
- Genetic and rare skin diseases.
- Pneumonia and Respiratory Infections
- Dysphagia Assessment and Management
- Invertebrate Immune Response Mechanisms
- Drug Transport and Resistance Mechanisms
- Proteoglycans and glycosaminoglycans research
- Gout, Hyperuricemia, Uric Acid
- Alcoholism and Thiamine Deficiency
- Ocular Disorders and Treatments
- Diabetes Treatment and Management
- Drug-Induced Hepatotoxicity and Protection
- Helicobacter pylori-related gastroenterology studies
- Bioinformatics and Genomic Networks
Sun Yat-sen University
2007-2024
Qingdao Agricultural University
2024
Third Affiliated Hospital of Sun Yat-sen University
2007-2024
First Hospital of Jilin University
2021
Jilin University
2021
Weatherford College
2021
Dongyang People's Hospital
2009-2018
Wenzhou Medical University
2009-2018
Sichuan University
2009
West China Hospital of Sichuan University
2009
Sonic hedgehog (Shh) signaling controls many aspects of human development, regulates cell growth and differentiation in adult tissues, is activated a number malignancies. Rheumatoid arthritis (RA) characterized by chronic synovitis pannus formation associated with activation fibroblast-like synoviocytes (FLS). We investigated whether Shh plays role the proliferation FLS RA. Expression related components (Shh, Ptch1, Smo, Gli1) RA synovial tissues was examined immunohistochemistry (IHC) IHC,...
Previous analysis of systems pharmacology has revealed a tendency rational drug design in the pharmaceutical industry. The targets new drugs tend to be close with corresponding disease genes biological networks. However, it remains unclear whether introduces disadvantages, i.e. side effects. Therefore, is important dissect relationship between and Based on recently released effect database, SIDER, here we analyzed effects design. We that incidence significantly associated network distance...
Objective. The aim of this study was to investigate the expression smoothened protein (Smo), a sonic hedgehog (Shh) signalling component, in synovium RA and its role survival apoptosis endothelial cells. Methods. Smo pxrotein synovial tissue examined by immunohistochemistry. Real-time PCR western blotting techniques were employed measure Shh components EA.hy926 cells exposed TNF-α presence or absence cyclopamine (a Smo-specific antagonist). Lastly, effect small interfering RNA on induced...
EBV (Epstein-Barr virus) serological tests have been used for many years as accessory diagnostic predictors of NPC (nasopharyngeal carcinoma). To date, IF (indirect immunofluorescence) assays still serve the 'gold standard' serodiagnosis. However, are time-consuming, unsuitable automatic handling and difficult to standardize. This makes their application in mass screening populations inconvenient. Some technical difficulties associated with overcome by development specific ELISAs, but, at...
Background . Preventing liver fibrosis from progressing to cirrhosis and even cancer is a key step in the treatment of chronic hepatitis B (CHB). This study aimed at constructing validating new nomogram for predicting significant (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>S</mml:mi><mml:mo>≥</mml:mo><mml:mn>2</mml:mn></mml:math>) CHB patients. Methods The was based on retrospective 252 predictive accuracy discriminative ability were evaluated by area under...
The objective of the present study was to conduct a multicentre, prospective evaluation diagnostic performance Biochip system for detection drug-resistant tuberculosis using smear-positive sputum specimens. This evaluated this new platform drug resistant and multidrug-resistant (MDR-TB) 1491 specimens collected from multiple clinical settings. Using conventional culture-based culturing drug-susceptibility testing as reference standards, biochip had sensitivity 86.08% specificity 97.7%...
<i>Objective:</i> To compare the antihypertensive effect and safety of amlodipine felodipine extended release (ER). <i>Methods:</i> Seventy-six patients with mild to moderate hypertension were randomized two groups in a double-blind manner. One group was treated 5.0–10.0 mg/day (group 1), other ER 2), for 12 weeks. Twenty-four-hour ambulatory blood pressure (ABP) monitoring at baseline after treatment used evaluate drug efficacy (BP) changes during ‘drug holiday’ (48...
Background Serum 25-hydroxyvitamin D level is associated with erectile dysfunction (ED) in observational studies. However, whether there a causal association between them remains uncertain. Objective Conduct two-sample Mendelian randomization (MR) analysis to investigate the effect serum and ED risk. Method Genome-wide study (GWAS) data of levels comprising 6,896,093 single nucleotide polymorphisms (SNP) from 496,949 people European ancestry were regarded as exposure for MR analysis....
Abstract Background Autophagy is a conserved catabolic process in eukaryotes that contributes to cell survival response multiple stresses and important for organism fitness. Extensive research has shown autophagy plays pivotal role both viral infection replication processes. Despite the increasing dedicated autophagy, investigations into shrimp are relatively scarce. Results Based on three different methods, total of 20 members ATGs were identified from F. chinensis , all which contained an...
To investigate the influence of alanine transaminase (ALT) on accuracy alpha-fetoprotein (AFP) for detecting hepatocellular carcinoma (HCC).This retrospective study recruited 799 patients with HCC, cirrhosis, and chronic hepatitis due to B infection healthy adults between July 2017 January 2019. Comparisons area under receiver operating characteristic curves (AUCs) HCC in different ALT levels were calculated.Serum gamma-glutamyl transferase significantly associated elevated AFP without HCC....
Eszopiclone, sold under the brand name Lunesta, is a new type of non-benzodiazepine hypnotic. Eszopiclone zopiclone dextrorotation, which classified as cyclopyrrolone. It functions by binding gamma-aminobutyric acid (GABA) receptors. Compared with benzodiazepines hypnotics, eszopiclone has higher selectivity for certain subunits GABA(A) receptor. So far, there are no reports about elevation serum enzymes or severe liver injury caused eszopiclone. Here, we present case report acute following...
Objective To analyze the application of recombinant VCA-BALF4(S) and VCA-BFRF3 proteins in serological diagnosis nasopharyngeal carcinoma (NPC). Methods DNA extracted from B95-8 cells was used as templates a polymerase chain reaction(PCR). VCA-BALF4 1008 bp (S) (aa 287-623) 531 bp(177 as) were generated inserted into pPICZaA vector.The plasmids transformed GS115 yeast by electroporation. The transformants in-duced methanol expressed proteins. synthesized coated to mi-croplate for detection...
Objective To realise the clinical features and to reduce diagnostic errors of hepatolenticular degeneration patients with liver injure. Methods Clinical manifestations, results las tests admitting diagnosis 23 cases were reviewed. Results All showed elevation serum transami-nase and/or total bilirubin. 17 cases(73.9% ) had manifestation malfunction while nervous system symptoms merely found in 2 cases. The decreased ceruloplasmin elevated 24 hour urinary cuprum detected 21 respectively....
Abstract Background Abnormally elevated AFP level is often observed in patients with chronic hepatitis infections without evident of (hepatocellular carcinoma) HCC. Our study aimed to investigate the influence alanine transaminase (ALT) on accuracy alpha-fetoprotein (AFP) for detecting Methods This retrospective recruited 799 HCC, cirrhosis and due B infection healthy adults between July 2017 January 2019. Comparisons area under receiver-operating curves (AUCs) HCC different ALT levels were...