Manli Wu

ORCID: 0000-0003-0024-5596
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Research Areas
  • Endometrial and Cervical Cancer Treatments
  • Ovarian cancer diagnosis and treatment
  • Liver Disease Diagnosis and Treatment
  • Hepatitis B Virus Studies
  • Pelvic floor disorders treatments
  • Urinary Tract Infections Management
  • Per- and polyfluoroalkyl substances research
  • Cervical Cancer and HPV Research
  • Intraperitoneal and Appendiceal Malignancies
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Anorectal Disease Treatments and Outcomes
  • Radiomics and Machine Learning in Medical Imaging
  • MicroRNA in disease regulation
  • Photoacoustic and Ultrasonic Imaging
  • Inhalation and Respiratory Drug Delivery
  • Bladder and Urothelial Cancer Treatments
  • MRI in cancer diagnosis
  • Urinary and Genital Oncology Studies
  • Statistical Methods in Epidemiology
  • Angiogenesis and VEGF in Cancer
  • Ultrasound and Hyperthermia Applications
  • Cancer-related molecular mechanisms research
  • Liver Disease and Transplantation
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Traditional Chinese Medicine Studies

Xi'an University of Architecture and Technology
2025

Zunyi Medical University
2024

Third Affiliated Hospital of Sun Yat-sen University
2019-2024

Sun Yat-sen University
2019-2024

Central Hospital of Wuhan
2024

Shaanxi Provincial People's Hospital
2024

The First Affiliated Hospital, Sun Yat-sen University
2024

Shaanxi Provincial People's Hospital
2024

Huizhou Central People's Hospital
2024

Shanxi Medical University
2024

Abstract Older livers are more prone to hepatic ischaemia/reperfusion injury (HIRI), which severely limits their utilization in liver transplantation. The potential mechanism remains unclear. Here, we demonstrate older exhibit increased ferroptosis during HIRI. Inhibiting significantly attenuates HIRI phenotypes. Mass spectrometry reveals that fat mass and obesity-associated gene (FTO) expression is downregulated livers, especially Overexpressing FTO improves phenotypes by inhibiting...

10.1038/s41467-024-49202-3 article EN cc-by Nature Communications 2024-06-04

Purpose To compare the diagnostic performance of time-intensity curve (TIC) analysis and subjective visual assessment contrast-enhanced US (CEUS) when integrated with Ovarian-Adnexal Reporting Data System (O-RADS) risk stratification system for characterizing adnexal lesions solid components. Materials Methods In this prospective multicenter study conducted from September 2021 to December 2022, female individuals suspected containing components detected at routine were enrolled. All...

10.1148/rycan.240024 article EN Radiology Imaging Cancer 2024-10-11

Background Liver stiffness measurement has been proposed as a noninvasive marker for predicting liver-related complications of cirrhosis. Purpose To evaluate the predictive value liver by using two-dimensional (2D) shear-wave elastography (SWE) events among patients with chronic hepatitis B. Materials and Methods This retrospective study recruited consecutive B who were referred biopsy between May 2011 2015. All underwent 2D SWE before biopsy, subset transient elastography. Patients followed...

10.1148/radiol.2020191481 article EN Radiology 2020-03-03

Abstract Purpose To explore the usefulness of liver stiffness measurements (LSMs) by sound touch elastography (STE) and quantification (STQ) in chronic hepatitis B (CHB) patients for staging fibrosis. Methods This prospective multicenter study recruited normal volunteers CHB between May 2018 October 2019. The underwent LSM STE supersonic shear imaging (SSI) or STQ acoustic radiation force impulse (ARFI). biopsy both STE/STQ. areas under receiver operating characteristic curves (AUCs)...

10.1055/a-1376-6734 article EN Ultraschall in der Medizin - European Journal of Ultrasound 2021-04-28

Background Two-dimensional (2D) shear-wave elastography (SWE) has been considered to be useful in predicting hepatocellular carcinoma (HCC) development patients with chronic hepatitis B (CHB). Purpose To develop a risk model using 2D SWE predict HCC CHB and compare its predictive value that of other models. Materials Methods Patients biopsy-proven who underwent US between April 2011 December 2015 were enrolled this study. After biopsy performed, the received regular follow-up for detection...

10.1148/radiol.2021204700 article EN Radiology 2021-08-24

To evaluate the individual and combined performances of Ovarian-adnexal Reporting Data System Ultrasound (O-RADS US) serum cancer antigen 125 (CA-125) in assessing adnexal malignancy risk women with different menopausal status.This retrospective study included patients masses scheduled for surgery based on their preoperative US histopathology results between January 2018 2020. O-RADS were used to assess by two experienced radiologists. The area under receiver operating characteristic curves...

10.1002/jum.16065 article EN Journal of Ultrasound in Medicine 2022-07-26

ABSTRACT Objective Transperineal ultrasound is a simple and highly repeatable method that has been used increasingly in the quantification of pelvic organ prolapse, but abnormal uterine descent on Chinese women still poorly defined. We aimed to determine optimal cut‐off define transperineal women. Methods This prospective multicenter study recruited who were examined tertiary‐level gynecological centers, due symptoms lower urinary tract and/or floor dysfunction, between February 2017...

10.1002/uog.23524 article EN Ultrasound in Obstetrics and Gynecology 2020-10-23

To investigate the influence of alanine transaminase (ALT) on accuracy alpha-fetoprotein (AFP) for detecting hepatocellular carcinoma (HCC).This retrospective study recruited 799 patients with HCC, cirrhosis, and chronic hepatitis due to B infection healthy adults between July 2017 January 2019. Comparisons area under receiver operating characteristic curves (AUCs) HCC in different ALT levels were calculated.Serum gamma-glutamyl transferase significantly associated elevated AFP without HCC....

10.1155/2020/2043715 article EN cc-by BioMed Research International 2020-12-14

The value of contrast-enhanced US (CEUS) in the discrimination benign from malignant adnexal masses remains controversial. This study aimed to construct a CEUS risk stratification model based on qualitative features and test its performance characterising with cystic components compared Ovarian-Adnexal Reporting And Data System (O-RADS) US. prospective multicentre recruited consecutive women undergoing both examinations solid component between September 2021 December 2022. Masses were...

10.1002/uog.26547 article EN Ultrasound in Obstetrics and Gynecology 2023-10-01

Objective To assess the applicability of sound touch elastography (STE) and quantify (STQ) in measuring liver spleen stiffness. Methods One hundred eighteen healthy volunteers were included underwent STE STQ. The success rate, variability reproducibility STQ analyzed. accurate sampling size number tests for also analyzed. Results The rates, variability, 97.5% 99.2%, 8.7% 12.0%, 0.917 0.916, respectively. While those with 76.3% 66.9%, 12.4% 16.4%, 0.847 0.706, 1.5 cm×1.0 cm yield...

10.3760/cma.j.issn.1004-4477.2019.07.008 article EN Zhonghua chaosheng yingxiangxue zazhi 2019-07-25

Objective To explore the repeatability of sound touch elastography (STE) and quantification (STQ) in detecting liver spleen stiffness. Methods A total 245 patients who underwent ultrasound examination Third People's Hospital Shenzhen from October 2017 to June 2018 were recruited this investigation. The informed consents all obtained local ethical committee approval was received. Among them, 157 male 88 female. aged 18 80 years with a median age 37 years. Two beginners selected perform...

10.3877/cma.j.issn.2095-3232.2019.04.020 article EN Chin J Hepat Surg(Electronic Edition) 2019-08-10

Abstract Background Abnormally elevated AFP level is often observed in patients with chronic hepatitis infections without evident of (hepatocellular carcinoma) HCC. Our study aimed to investigate the influence alanine transaminase (ALT) on accuracy alpha-fetoprotein (AFP) for detecting Methods This retrospective recruited 799 HCC, cirrhosis and due B infection healthy adults between July 2017 January 2019. Comparisons area under receiver-operating curves (AUCs) HCC different ALT levels were...

10.21203/rs.3.rs-19942/v1 preprint EN cc-by Research Square (Research Square) 2020-04-03
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