A5101774245- Geophysical and Geoelectrical Methods
- Seismic Imaging and Inversion Techniques
- MicroRNA in disease regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Extracellular vesicles in disease
- Digital Holography and Microscopy
- Seismic Waves and Analysis
- Geophysical Methods and Applications
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Advanced Vision and Imaging
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- Liver physiology and pathology
- Catalytic C–H Functionalization Methods
- Advanced Image Processing Techniques
- Hydrocarbon exploration and reservoir analysis
- Mesenchymal stem cell research
- Advanced biosensing and bioanalysis techniques
- Pancreatic and Hepatic Oncology Research
- Lignin and Wood Chemistry
- Postharvest Quality and Shelf Life Management
- Neurogenesis and neuroplasticity mechanisms
- Gold and Silver Nanoparticles Synthesis and Applications
Third Affiliated Hospital of Sun Yat-sen University
2021-2025
Sun Yat-sen University
2016-2025
Key Laboratory of Guangdong Province
2022-2025
Shandong Academy of Sciences
2020-2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
Shenyang Ligong University
2024
Qilu University of Technology
2019-2024
Integrated Oncology (United States)
2024
National Clinical Research
2024
Guangdong Provincial People's Hospital
2024
Surface enhanced Raman spectroscopy (SERS) is an attractive analytical technique, which enables single-molecule sensitive detection and provides its special chemical fingerprints. During the past decades, researchers have made great efforts towards ideal SERS substrate, mainly including pioneering works on preparation of uniform metal nanostructure arrays by various nanoassembly nanotailoring methods, give better uniformity reproducibility. Recently, nanoparticles coated with inert shell...
Graphene is exploited to serve as a seamless and inert veil fabricate surface-enhanced Raman spectroscopy (SERS) substrate with passivated surface. This novel approach inherits the concept of metal–molecule isolation (for more well-defined surface interactions) results in few superiorities. We find SERS performance graphene-veiled highly morphology-dependent, dynamic process thermal annealing investigated detail by in-situ spectroscopy. As service our authors readers, this journal provides...
Abstract Older livers are more prone to hepatic ischaemia/reperfusion injury (HIRI), which severely limits their utilization in liver transplantation. The potential mechanism remains unclear. Here, we demonstrate older exhibit increased ferroptosis during HIRI. Inhibiting significantly attenuates HIRI phenotypes. Mass spectrometry reveals that fat mass and obesity-associated gene (FTO) expression is downregulated livers, especially Overexpressing FTO improves phenotypes by inhibiting...
The bone marrow microenvironment facilitates the proliferation and survival of leukemia cells, contributing to disease relapse. Bone marrow-derived mesenchymal stem cells (MSCs) are well known promote cancer chemoresistance via soluble factors cell adhesion. However, little is about effects MSCs on mitochondrial dynamics T-cell acute lymphoblastic (T-ALL) or how this may influence these cells. Here, we tested both indirect (Transwell) direct coculture strategies, found that protected T-ALL...
Background and Aims: Immune cells play a crucial role in liver aging. However, the impact of dynamic changes local immune microenvironment on age-related injury remains poorly understood. We aimed to characterize intrahepatic at different ages investigate key mechanisms associated with Approach Results: carried out single-cell RNA sequencing mouse tissues 4 ages, namely, newborn, suckling, young, aged stages. The transcriptomic landscape, cellular classification, intercellular communication...
Acute lung injury (ALI) remains a common cause of morbidity and mortality worldwide, to date, there is no effective treatment for ALI. Previous studies have revealed that topical administration mesenchymal stem cells (MSCs) can attenuate the pathological changes in experimental acute injury. Heat shock (HS) pretreatment has been identified as method enhance survival function cells. The present study aimed assess whether HS-pretreated MSCs could immunomodulation recovery from ALI.HS was...
The Warburg effect is well-established to be essential for tumor progression and accounts the poor clinical outcomes of hepatocellular carcinoma (HCC) patients. An increasing body literature suggests that circular RNAs (circRNAs) are important regulators HCC. However, few circRNAs involved in HCC have hitherto been investigated. Herein, we aimed explore contribution circFOXK2 glucose metabolism reprogramming HCC.In present study, different primers were designed identify 14 originating from...
There are two nonzero cross-components of a triaxial induction logging tool in the medium coordinate system transversely isotropic (TI) formation. The sum holds dependence on only horizontal conductivities with little nonlinearity and small shoulder bed effect horizontally layered Based generalized reflection coefficient method, simplified formulas derived to analyze its response characteristics. Numerical results show that apparent conductivity obtained from is square-looking log high...
Abstract Hepatic ischemia‐reperfusion injury (HIRI) is a prevalent issue during liver resection and transplantation, with currently no cure or FDA‐approved therapy. A promising drug, Cyclosporin (CsA), ameliorates HIRI by maintaining mitochondrial homeostasis but has systemic side effects due to its low bioavailability high dosage requirements. This study introduces biomimetic CsA delivery system that directly targets hepatic lesions using mesenchymal stem cell (MSC) membrane‐camouflaged...
Compared to vertical wells, horizontal wells may exhibit identical logging curve characteristics corresponding different target formations, and the same formation can display varying features. To clarify these response character-istics, a numerical simulation was conducted using fast Hankel transform method simulate array induction responses for wells. The covers both constant-inclination well trajectories in simple formations waveform Oklahoma formations. Conduct detailed analysis of impact...
Abstract Fibrosis is a disease that negatively affects liver regeneration, resulting in severe complications after surgery. However, there still no clinically effective treatment for promoting fibrotic regeneration because the underlying hepatocellular mechanism remains poorly understood. Through microRNA microarrays combined with application of AAV6, we found high expression miR-181a-5p activated hepatic stellate cells (HSCs) suppressed growth factor (HGF) and partially contributed to...
Abstract Aging‐related decline and adaptation are complex, multifaceted processes that affect various tissues increase risk of chronic diseases. To characterize key changes in cross‐tissue aging, we performed comprehensive proteomic metabolomic analyses across 21 solid plasma samples, alongside shotgun metagenomic profiling fecal microbial communities young aged mice. Our findings revealed widespread aging‐rewired inflammation, characterized by complement system activation universal...
Abstract Neural stem/progenitor cells (NSPCs) transplantation provides an alternative approach for various central nervous system (CNS) diseases treatment, while the difficulties in NSPC acquisition and expansion limit their further application. Unveiling mechanism of stemness regulation may contribute to its Nestin, generally recognized as a marker NSPCs, plays crucial role CNS development maintenance. Here, we report that Nestin loss triggers mitochondrial network remodeling enhances...
Abstract Castration-resistant prostate cancer (CRPC), which is considered to contain stem cells (CSCs), leads a high relapse rate in patients with (PCa). However, the markers of CSCs are controversial. Here we demonstrate that CD51, part, correlates poor prognosis PCa patients. Further, find CD51 functional molecule able promote malignancy through enhancing tumor initiation, metastatic potential, and chemoresistance. Moreover, elevated expression specimens p53 loss function. Mechanistically,...