A5034009898- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Analysis
- Metabolomics and Mass Spectrometry Studies
- Ginseng Biological Effects and Applications
- Natural product bioactivities and synthesis
- Gut microbiota and health
- Phytochemistry and Biological Activities
- Phytochemistry and biological activity of medicinal plants
- Analytical Chemistry and Chromatography
- MicroRNA in disease regulation
- Chromatography in Natural Products
- Neurological Disease Mechanisms and Treatments
- Nanoparticle-Based Drug Delivery
- Berberine and alkaloids research
- Ginkgo biloba and Cashew Applications
- Cancer-related molecular mechanisms research
- Curcumin's Biomedical Applications
- Quinazolinone synthesis and applications
- Medicinal Plants and Bioactive Compounds
- Circular RNAs in diseases
- HIV/AIDS drug development and treatment
- Biological and pharmacological studies of plants
- Cancer Research and Treatment
- Membrane-based Ion Separation Techniques
- Plant-based Medicinal Research
Kanion Pharmaceutical (China)
2017-2025
Nanjing University of Chinese Medicine
2023-2025
Nanjing Medical University
2025
Second Xiangya Hospital of Central South University
2025
Central South University
2025
Sun Yat-sen University
2025
Agricultural Genomics Institute at Shenzhen
2024
Jiangnan University
2024
Chinese Academy of Agricultural Sciences
2024
Beijing Graphene Institute
2024
Transthyretin plays an important role in the transport and distribution of thyroid hormone central nervous system (CNS). This study replicated extended to patients with nonrefractory depressive illness a pilot indicating that refractory major depression have significantly lower levels CSF transthyretin than do healthy comparison subjects.Lumbar punctures were performed drug-free subjects DSM-III-R (N = 18), bipolar disorder, depressed phase 1), 24). concentrations transthyretin, determined...
In order to enhance the therapeutic value of curcumin in liver cancer treatment, glycyrrhetinic acid-modified pH-sensitive liposomes (GA-pH-Lip@Cur) was developed.GA-pH-Lip@Cur prepared using a thin film dispersion ultrasonication method, and optimal formulation process selected through single-factor experiments Box-Behnken design-response surface methodology. The were evaluated for their morphological appearance, particle size, vitro release at different pH levels, biocompatibility....
A reliable method, combining qualitative analysis by high‐performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry and quantitative assessment photodiode array detection, has been developed to simultaneously analyze flavonoids alkaloids in lotus leaf extracts. In the analysis, a total of 30 compounds, including 12 flavonoids, 16 alkaloids, two proanthocyanidins, were identified. The fragmentation behaviors four types flavone glycoside three alkaloid are...
// Farhan Anwar Khan 1,2,3,* , Muhammad Faisal 1,2,* Jin Chao 1,2 Kai Liu Xi Chen 2 Gang Zhao Harish Menghwar Hui Zhang Xifang Zhu Asif Rasheed Chenfei He Changmin Hu Yingyu 1,4 Eric Baranowski 6,7 Huanchun 1,2,4 and Aizhen Guo 1,2,4,5 1 The State Key Laboratory of Agricultural Microbiology, Huazhong University, Wuhan, China College Veterinary Medicine, 3 Department Animal Health, University Agriculture, Peshawar, Pakistan 4 Development Diagnostic Products, Ministry International Joint...
As an attractive biomaterial for bone reconstruction, injectable biomaterials have many prominent characteristics such as good biocompatibility and bone-filling ability. However, there are weak load-bearing scaffolds. In this study, polyvinyl alcohol (PVA) bioactive glass (BAG) were interpenetrated into sodium alginate (SA) network to obtain self-enhanced hydrogel. The optimum ratio of PVA/SA/BAG hydrogel was determined based on injectability, gelation time chemical characterization. Results...
To elucidate the anti-inflammatory mechanism of Reduning Injection (RDN) by analyzing potential biomarkers and metabolic pathways carrageenan-induced inflammatory model from overall level.Rat was established carrageenan. UPLC-Q-TOF/MS used to detect analyze changes endogenous metabolites in serum urine rats. Combined with multivariate analysis databases analysis, inflammatory-related were screened identified possible pathways. The reliability biological significance these verified network...
Qi‐Wei‐Tong‐Bi oral liquid (QWTB), a famous Chinese medicine preparation composed of seven crude drugs has good therapeutic effect on rheumatoid arthritis and is widely used in China. However, its chemical composition quality control have not been comprehensively systematically investigated. In this study, high‐performance chromatography coupled with quadrupole time‐of‐flight mass spectrometry was employed for profiling. As result, 100 components were chemically characterized. Additionally,...
Diabetic nephropathy (DN) is one of the main complications diabetes and a major cause end-stage renal disease, which has severe impact on quality life patients. Strict control blood sugar pressure, including use renin–angiotensin–aldosterone system inhibitors, can delay progression diabetic but cannot prevent it from eventually developing into disease. In recent years, many studies have shown close relationship between gut microbiota imbalance occurrence development DN. This review discusses...
Tumors occurring along the hypothalamus-pituitary axis receive axonal projection from neuroendocrine neurons, but it remains unclear whether neuronal activity drives tumor expansion. Craniopharyngioma is a common suprasellar with propensity for invading hypothalamus, leading to devastating endocrine and metabolic disorders. Here, we developed two autochthonous animal models that faithfully recapitulate molecular pathology, clinical manifestations, transcriptomic profiles of papillary...
It has been difficult to directly measure the spontaneous hydrolysis rate of urea and, thus, 1,1,3,3-tetramethylurea (Me4U) was used as a model determine "experimental" constant for hydrolysis. The use Me4U based on an assumption that should be 2.8 times because acetamide is N,N-dimethyl-acetamide present first-principles electronic-structure calculations competing non-enzymatic pathways have demonstrated dominant pathway neutral via CN addition both (when pH < ∼11.6) and (regardless pH),...