A5028474805- Pituitary Gland Disorders and Treatments
- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- Cerebrospinal fluid and hydrocephalus
- RNA modifications and cancer
- Regulation of Appetite and Obesity
- Cancer, Hypoxia, and Metabolism
- Neuroblastoma Research and Treatments
- Head and Neck Surgical Oncology
- Clusterin in disease pathology
- Mitochondrial Function and Pathology
- Cancer-related molecular mechanisms research
- Growth Hormone and Insulin-like Growth Factors
- FOXO transcription factor regulation
- Proteoglycans and glycosaminoglycans research
Lanzhou University Second Hospital
2020-2024
Beijing Tian Tan Hospital
2022-2024
Capital Medical University
2022-2024
Lanzhou University
2020-2024
Decorin exhibits inhibitory effects in tumorigenesis various types of cancers. The clinical characteristics 42 patients with GBM were reviewed and analyzed. Lentiviral constructs for decorin overexpression shRNA-mediated silencing established U87MG cells T98G cells, respectively. expressions EMT- autophagy-associated markers detected cell lines. migration invasion the glioma assayed to reflect malignant behavior GBM. A mouse xenograft model was used verify effect on autophagy vivo . Reduced...
Tumors occurring along the hypothalamus-pituitary axis receive axonal projection from neuroendocrine neurons, but it remains unclear whether neuronal activity drives tumor expansion. Craniopharyngioma is a common suprasellar with propensity for invading hypothalamus, leading to devastating endocrine and metabolic disorders. Here, we developed two autochthonous animal models that faithfully recapitulate molecular pathology, clinical manifestations, transcriptomic profiles of papillary...
Medulloblastoma is the most common malignant brain tumor in children. There are four groups, each with different causal mutations, affected pathways and prognosis. Here, we investigated role of mitochondria medulloblastoma whether there differences between groups.We compared gene expression levels groups (MB-WNT, MB-SHH, MB-G3 MB-G4), focus on genes associated mitochondria. We used several tools including Salmon, Tximeta, DESeq2, BiomaRt, STRING, Ggplot2, EnhancedVolcano, Venny 2.1...
Obesity presents a significant challenge in managing patients with craniopharyngioma (CP). Cyst fluid (CF), rich inflammatory mediators, is implicated CP-related obesity, though the precise mechanism remains unclear. This study investigated impact of CF or C-X-C motif chemokine ligand-1 (CXCL1) injections on body weight, Lee index, plasma lipid profiles, hepatic accumulation, leptin levels, NF-κB pathway, suppressor cytokine signaling 3 (SOCS3) expression, and sensitivity rats....
Background. Craniopharyngioma (CP) is a benign slow-growing tumor. It tends to affect children, and the number of patients on rise. Considering high morbidity mortality CP, it urgent pivotal identify new biomarkers uncover etiology pathogenesis CP. Methods. The “limma” package was utilized calculate data from Gene Expression Omnibus (GEO) database. Based differentially expressed genes (DEGs), gene ontology pathway analysis were deduced DAVID web tool. Further, we constructed protein-protein...
Our study attempted to identify hub genes related isocitrate dehydrogenase (IDH) mutation in glioma and develop a prognostic model for IDH-mutant patients. In first step, ten significantly associated with the IDH status were identified by weighted gene coexpression analysis (WGCNA). The functional enrichment demonstrated that most enriched terms of these cadherin binding glutathione metabolism. Three linked survival 328 samples separated into two datasets: training set (N = 228) test 100)....
Abstract Surgical procedures may affect the changes in gastric contents and volume, resulting a potential risk of pulmonary aspiration. We aimed to assess differences preoperative postoperative volume patients undergoing endoscopic endonasal transsphenoidal surgery using ultrasound determine factors associated with intraoperative changes. This prospective study enrolled 71 adult diagnosed pituitary adenoma. Semi - quantitative (Perlas score: grade 0, 1, or 2) (cross-sectional area, CSA)...