A5100600403- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Cerebrospinal fluid and hydrocephalus
- Pituitary Gland Disorders and Treatments
- Functional Brain Connectivity Studies
- Neuroblastoma Research and Treatments
- Advanced Neuroimaging Techniques and Applications
- Neurofibromatosis and Schwannoma Cases
- Traumatic Brain Injury and Neurovascular Disturbances
- Growth Hormone and Insulin-like Growth Factors
- Fetal and Pediatric Neurological Disorders
- Vascular Malformations Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Traumatic Brain Injury Research
- Brain Metastases and Treatment
- Neonatal and fetal brain pathology
- Testicular diseases and treatments
- Optical Imaging and Spectroscopy Techniques
- Traumatic Ocular and Foreign Body Injuries
- Cleft Lip and Palate Research
- Trauma Management and Diagnosis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Brain Tumor Detection and Classification
- Restraint-Related Deaths
- Craniofacial Disorders and Treatments
Capital Medical University
2014-2024
Beijing Tian Tan Hospital
2014-2024
Beijing Institute of Neurosurgery
2014-2024
Central China Normal University
2023
Capital University
2022-2023
Zhongshan Hospital
2019-2022
Guangxi University
2022
Chinese Institute for Brain Research
2017-2020
The First Affiliated Hospital, Sun Yat-sen University
2019
Fudan University
2019
Background: Adamantinomatous craniopharyngioma (ACP) is a benign but maldevelopmental tumor with high recurrence rate. Objective: Theaim of this study was to investigate the dysregulated biological molecules that play important roles in recurre
This study examines functional brain network changes in children with frontal lobe tumors (FLT). Ten pediatric FLT patients from Beijing Tiantan Hospital and 20 healthy were compared terms of cognitive performance resting-state magnetic resonance imaging (rs-fMRI) connectivity. The group showed lower performance, particularly visual working memory domains, but had comparable attention abilities to the controls. There notable differences connectivity between default mode (DMN) sensorimotor...
Pediatric intracranial space-occupying lesions are common, with prognoses improving markedly in recent years, significantly extending survival. As such, there is an imperative to pay increased attention the postoperative cognitive functions and brain network alterations these children because factors influence their quality of life. Temporal variability (TV) analysis networks captures full extent resting-state activities, reflecting rehabilitation potential. However, previous research rarely...
Objective Hypothalamic-pituitary axis dysfunction is a common complication in post-operative craniopharyngioma(CP) patients, and it greatly impacts the long-term quality of life such patients. To better understand effects postoperative hypothalamic-pituitary hormone replacement therapy patients with childhood CP, we assessed approximately 200 childhood-onset CP postoperatively. Methods Clinical details who underwent sellar tumor resection Beijing Children’s Hospital Tiantan from 2018 to 2019...
Abstract Background Craniopharyngiomas are low‐grade malignancies (WHO I) in the sellar region. Most cases of childhood‐onset craniopharyngioma adamantinomatous craniopharyngioma, and neurosurgery is treatment choice. Affected patients have postoperative complications, including water electrolyte disturbances, because these develop near hypothalamus pituitary gland. Determining serum sodium fluctuation patterns can reduce mortality improve prognosis. Objective To measure changes levels...
Tumors occurring along the hypothalamus-pituitary axis receive axonal projection from neuroendocrine neurons, but it remains unclear whether neuronal activity drives tumor expansion. Craniopharyngioma is a common suprasellar with propensity for invading hypothalamus, leading to devastating endocrine and metabolic disorders. Here, we developed two autochthonous animal models that faithfully recapitulate molecular pathology, clinical manifestations, transcriptomic profiles of papillary...
Background: External ventricular drainage (EVD) is common after brain surgery. However, the incidence of EVD-related infection (ERI) still relatively high and can increase morbidity mortality. Objective: The objective this study was to analyze ERI factors in pediatric population post-brain tumor Methods: From January 2016 December 2017, 147 patients <18 years old underwent removal at Beijing Tiantan Hospital had postoperative EVD. We recorded basic demographic data as well several risk...
Background: The role and effectiveness of primary surgical treatment for sporadic chiasmatic-hypothalamic glioma (CHG) are not clear. present study was to describe CHG visual acuity (VA) outcomes after surgery analyze the relevant factors affecting VA improvement. Methods: Forty-five pediatric patients who met inclusion criteria were included in a retrospective study. All received intratumor partial resection. Disease characteristics, strategies, complications, outcome analyzed. Univariate...
Abstract Background Studies on cognition and brain networks after various forms of injury mainly involve traumatic injury, neurological disease, tumours, mental disease. There are few related studies surgical even fewer pediatric studies. This study aimed to preliminarily explore the cognitive network changes in children with focal, unilateral, well-bounded intracranial space-occupying lesions (ISOLs) short term period surgery. Methods We enrolled 15 patients (6–14 years old) ISOLs admitted...
Intracranial lesions in children often have good prognoses, allowing long-term survival. Cognitive functions, crucial for life quality, need more attention. Previous research has focused on adults, with pediatric studies limited by varied and complex treatments. This study aims to evaluate cognitive brain network changes frontal lobe lesions, which significantly impact function, using a before-and-after comparison. The enrolled 20 who underwent fMRI tests before after surgery, only surgical...
Cancer is the main cause of death by disease in children. Children experience highest incidence cancer first year life. However, there no comprehensive registration system for children with tumors China.
Postoperative peritumoral brain edema (PTBE) is the progressively exacerbating cerebral following meningiomas resection.The study aims to identify predictive factors of postoperative PTBE.A retrospective was conducted on 117 cases patients who underwent meningioma. The histopathological features tumors were re-assessed according WHO 2016 classification. Clinical and pathohistological analyzed.Thirteen (11.1%) diagnosed having PTBE. Preoperative seizure (odds ratio [OR] = 6.125, P 0.039)...
Abstract Objective To investigate the expression of H3K27me3 in different anatomical sites and analyze its prognostic value children with ependymoma. Methods A total 188 diagnosed ependymoma were admitted to Department Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, between 2012 2017, regular follow‐up was conducted. Expression analyzed by immunohistochemistry scored semiquantitatively. The correlation Kaplan‐Meier Cox regression survival analyses. Results Of ependymoma,...