A5038510476- Cervical Cancer and HPV Research
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Endometrial and Cervical Cancer Treatments
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Reproductive tract infections research
- Cancer Genomics and Diagnostics
- Genital Health and Disease
- Virus-based gene therapy research
- Lung Cancer Treatments and Mutations
- Cancer-related Molecular Pathways
- CAR-T cell therapy research
- Ovarian cancer diagnosis and treatment
- Breast Cancer Treatment Studies
- Neuroblastoma Research and Treatments
- Folate and B Vitamins Research
- RNA Interference and Gene Delivery
- Cancer Risks and Factors
- Neuroendocrine Tumor Research Advances
- Neonatal Health and Biochemistry
- Kruppel-like factors research
- Natural product bioactivities and synthesis
Second Hospital of Shanxi Medical University
2009-2025
Shanxi Medical University
2009-2025
Sichuan Mianyang 404 Hospital
2025
Chinese PLA General Hospital
2012-2024
First Affiliated Hospital of Wannan Medical College
2023
Peking University First Hospital
2003-2021
Peking University
2003-2021
Second Hospital of Hebei Medical University
2020-2021
Hebei Medical University
2020-2021
Luye Pharma (China)
2020-2021
ABSTRACT Aims: Several studies have demonstrated administration of mesenchymal stem cells (MSC) could reverse kidney injury by paracrine mechanisms rather than MSC transdifferentiation. Recently, a few researchers found microvesicles (MV) derived from might be mechanism for cell‐to‐cell communication. The aim this study was to investigate the repair effects MV in 5/6 subtotal nephrectomy (Nx) mice model. Methods: animals were randomly divided into four groups: Control, Nx, Nx + and group....
Human papillomavirus(HPV) infection is a necessary factor for the development of cervical cancer. The HPV vaccine currently available, but there still lack large-scale research on distribution and risk factors HPV. aim this study to investigate genotype in Yangqu which located North China. This enrolled 10086 women aged <65 years from County. genotypes were identified via standard DNA testing. overall prevalence was 8.92%. high-risk types 8.80%, it 0.38% low-risk types. Single accounted...
Lipusu is the first commercialized liposomal formulation of paclitaxel and has demonstrated promising efficacy against locally advanced lung squamous cell carcinoma (LSCC) in a small-scale study. Here, we conducted multicenter, randomized, phase 3 study to compare safety cisplatin plus (LP) versus gemcitabine (GP) as first-line treatment or metastatic LSCC.Patients enrolled were aged between 18 75 years, had (clinical stage IIIB, ineligible for concurrent chemoradiation surgery) (Stage IV)...
This is a phase Ib study of anlotinib plus programmed death-ligand 1 (PD-L1) inhibitor TQB2450 for platinum-resistant or -refractory ovarian cancer. Thirty-four patients are enrolled and receive treatment. The objective response rate (ORR) 47.1%, the disease control 97.1%. median duration (DOR) has not been reached, 61.3% have DOR at least 8 months. progression-free survival (PFS) 7.8 months, overall (OS) reached. PD-L1-positive group an ORR 25.0%, whereas PD-L1-negative 92.9%....
Epithelial ovarian cancer (EOC) is a that affects the female reproductive system and highly lethal. It poses significant challenges in terms of treatment often has poor prognosis. In recent years, with advent PARPi, entered new stage full-process management. Although more drugs have been approved, therapeutic effect PARPi still very limited. With rapid development PD-1/PD-L1, CTLA-4, oncolytic viruses, vaccines, adoptive cell therapy, etc., tumor immunotherapy provided opportunities for...
Objective: To investigate the role of YTHDF2 in cervical lesions and its potential molecular mechanism. Methods: Gene expression data tissue were obtained from GEO database to analyze mRNA perform pathway enrichment analysis. Patients with diagnosed by thinprep cytologic test Gynecological Outpatient Department Maternal Child Health Hospital Jiexiu, Shanxi Province, selected as research subjects. Data exfoliated cells collected. HPV infection status was detected flow-through hybridization,...
Pan-immune inflammation value (PIV) is associated with prognosis in immune and inflammatory diseases, a hallmark of pulmonary embolism (PE). Nonetheless, the link between PIV PE remains unclear. However, few studies have specifically focused on critically ill patients ICUs. This study retrospectively analyzed electronic health data from Medical Information Mart for Intensive Care (MIMIC-IV) database. The primary outcome was 28-day ACM; secondary outcomes were 90-day, 1-year, ICU, in-hospital...
To investigate the effect of folate status on cervical intraepithelial neoplasia (CIN) progression and its relationship with high-risk human papillomavirus (hrHPV). We evaluated 20 000 sexually active women aged <65 years in Yangqu County by using a questionnaire; subjects were also screened ThinPrep cytologic test (TCT). Patients abnormal TCT results (other than glandular cell abnormalities) who willing to provide informed consent further diagnosed colposcopy histopathological examination....
We aimed to investigate the risk factors for cervical intraepithelial neoplasia (CIN) in Jiexiu, Shanxi Province, China. Twenty thousand eligible married women (age: 18-65 years) were administered with a questionnaire on potential CIN and underwent liquid based Pap test. All abnormal cytological results colposcopy biopsy. Based biopsy pathology results, then assigned either study group (with CIN) or control (negative histological volunteered participate follow up study). The both vaginal...
Controversies abound concerning hematopoietic stem cell transduction by recombinant adeno-associated virus 2 (AAV) vectors. For human cells, we have shown that this problem is related to the extent of expression cellular receptor for AAV. At least a small subset murine on other hand, does express both AAV and coreceptor, yet transduced poorly. In present study, found ∼85% genomes were in cytoplasmic fraction primary c-Kit+Lin- cells. However, when mice injected intraperitoneally with...
Objective To identify risk factors for ovarian pregnancy (OP) and compare clinical features between OP tubal (TP) patients. Design Case–control study. Setting University hospital. Participants A case–control study was conducted from January 2005 to May 2014. Women diagnosed with were recruited as the case group (n=71), 145 women TP 146 intrauterine (IUP) matched controls at a ratio of 1:2:2. who refused interviews or provided incomplete information excluded. Results lower than in serological...
Cisplatin is one of the most common chemotherapeutic drugs for non-small cell lung cancer (NSCLC). However, response rate limited because drug resistance. Histone deacetylase inhibitors (HDACis), which can alter DNA accessibility by regulating chromatin structure and inducing apoptosis, exhibit a synergistic action with cisplatin. no biomarkers that predict efficacy combination HDACis cisplatin have been reported. Our study found panobinostat, an HDAC inhibitor, increased sensitivity several...
Natural QR (quinine oxidoreductase) inducers play critical roles in cancer chemoprevention. Because tea seed saponins of Camellia sinensis exhibited significant inducing activities, this study aimed to find bioactive theasaponin derivatives by structure modification on the sugar part and acyl groups. Three kinds hydrolysis methods were employed afford 7 major acid products (1–7), 10 alkaline hydrolysates (8–17) 2 (3, 18) oxidative alkaline-degradation. They elucidated as kaempferol (1),...
The aim of this study was to examine the relationship between miR-375 expression and proliferation, apoptosis, migration cervical cancer cells. To further explore potential target gene miR-375, insulin-like growth factor 1 receptor (IGF-1R) detected in overexpressed inhibited cells, which clarified mechanism development cancer.In a cell line (Caski), overexpression knockdown were achieved by transfection with synthetic mimic or miR-375-targeting inhibitor oligonucleotides, respectively,...
Introduction: Accumulating evidence showed that a large number of microRNAs (miRNAs) are abnormally expressed in lung cancer tissues and play critical roles development progression. The aim this study is to identify the differentially miRNAs (DEMs) between non-small cell (NSCLC) normal tissues, evaluate prognostic value potential target gene functional enrichment DEMs. Materials Methods: We first downloaded high-throughput miRNA data from Cancer Genome Atlas Project (TCGA) database,...
Background.Tripartite motif-containing 22 (TRIM22) is characterized by a canonical RING domain with ubiquitin E3 ligase activity and closely associated tumorigenesis.As product of TRIM22 transcription, whether hsa_circ_TRIM22 has function regulating tumorigenesis unclear.Thus, we aimed to explore the role mechanism in human papillomavirus (HPV) 16 positive cervical cancer (CC).Methods.We collected HPV16-positive tissues including chronic cervicitis, high-grade squamous intraepithelial...
Cervical cancer, induced by persistent HPV infection, has a high mortality rate. The E3 ubiquitin ligase Cullin 2 (CUL2) is critical for HPV16 E7-mediated degradation of retinoblastoma protein (pRb). Dysregulation microRNAs (miRNAs) during tumorigenesis; however, the association between miRNA networks and CUL2, specific to cervical remains unknown. Herein, we determined profiles in cancer tissues using an Affymetrix array. We found that miR-154-5p was downregulated progression real-time...