A5111510893- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Advanced Glycation End Products research
- Epigenetics and DNA Methylation
- Natural Antidiabetic Agents Studies
- Cancer Cells and Metastasis
- Microbial Metabolic Engineering and Bioproduction
- Pancreatic and Hepatic Oncology Research
- Chronic Disease Management Strategies
- Ferroptosis and cancer prognosis
- Mesenchymal stem cell research
- Nosocomial Infections in ICU
- Mycobacterium research and diagnosis
- Plant biochemistry and biosynthesis
- Hippo pathway signaling and YAP/TAZ
- Pneumonia and Respiratory Infections
- Dermatologic Treatments and Research
- Trigeminal Neuralgia and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Chemokine receptors and signaling
- Wnt/β-catenin signaling in development and cancer
Anhui Medical University
2022-2025
First Affiliated Hospital of Anhui Medical University
2022-2025
Huizhou University
2025
Guangzhou University of Chinese Medicine
2025
Huazhong University of Science and Technology
2010-2024
Union Hospital
2010-2024
Henan Cancer Hospital
2014-2024
Zhengzhou University
2014-2024
Shanghai University of Traditional Chinese Medicine
2024
Jinan University
2018-2022
The high-mobility group box protein 1 (HMGB1) is increasingly recognized as an important inflammatory mediator. In some cases, the release of HMGB1 regulated by poly(ADP-ribose) polymerase-1 (PARP-1), but mechanism still unclear. this study, we report that PARP-1 activation contributes to LPS-induced PARylation HMGB1, insufficient direct its migration from nucleus cytoplasm; regulates translocation cytoplasm through upregulating acetylation HMGB1. mouse bone marrow-derived macrophages,...
Abstract Objectives Lung cancer is still a disease with high morbidity and mortality in the world. Micro RNA s have been proven to act as an indispensable role reuse of multiple solid tumours. Although miR‐1258 plays vital suppressing metastasis breast gastric cancer, specific biological function non‐small‐cell lung remains unclear. Methods The differential expression NSCLC tissues corresponding paracancerous was detected by qRT ‐ PCR ISH . Flow cytometry CCK ‐8, EdU, tubule formation,...
Significance Upon brassinosteroid (BR) treatment, BRASSINAZOLE RESISTANT1 (BZR1) is dephosphorylated and accumulate in the nucleus. However, it was unclear whether these two processes are interdependent. Here, we show that BR signaling first recruits phosphorylated BZR1 to nucleus where by protein phosphatase 2A (PP2A). constitutively degraded via a BR- 26S proteosome–independent mechanism; however, treatment activates different proteosome–dependent pathway increases turnover rate. These...
Background: In this study, we investigated the relationship between serum lactate dehydrogenase (LDH) level and disease progression prognosis of patients with COVID-19. Methods: We retrospectively reviewed information 1,751 COVID-19 from Leishenshan Hospital in Wuhan, China. Univariate multivariate Cox regression analyses as well Logistics analyses, Kaplan-Meier curves were used to determine association LDH levels patients. Results: was an independent risk factor for in-hospital death no...
Background Chronic obstructive pulmonary disease (COPD) is a common inflammatory disorder that significantly aggravated by tobacco smoke exposure. Purpose This study aimed to explore the effect of glabridin (Glab) on response and explain molecular mechanism Glab in vitro model human bronchial epithelial cells (16HBE) induced cigarette extract (CSE). Materials Methods We constructed an COPD using CSE induction 16HBE applied with differential concentration gradients model. Cell viability was...
PRR11 is a potential candidate oncogene that has been implicated in the pathogenesis of lung cancer, however role gastric cancer currently unclear. In present study, we investigated by evaluating its expression status samples from cohort 216 patients with cancer. was found to be overexpressed 107 (49.5%) immunohistochemistry tissue microarrays generated using patient samples. Furthermore, overexpression correlate significantly clinicopathologic features such as tumor invasion,...
Dysregulation of homeobox B7 (HOXB7), a member the genes family, was suggested to play role in regulation tumorigenesis and metastases some cancers. However, functions HOXB7 association with lung adenocarcinoma (LAC) have not been investigated. The correlation between level expression cancer progression patients is known. In this study, through analysis 75 LAC samples their corresponding normal epithelium tissues immunohistochemistry (IHC), we demonstrate that overexpressed specimens...
Radiotherapy is a widely used treatment for cancer. However, recent studies suggest that ionizing radiation (IR) can promote tumor invasion and metastasis. Bmi-1, member of the polycomb group protein family, has been observed as regulator oxidative stress promotes metastasis in some tumors. But, its potential role induced by IR breast cancer not explored. In our study, we found increased levels Bmi-1 were correlated to EMT cells. Through analyzing state IR, metastatic cells either be...
Introduction: Accumulating evidence showed that a large number of microRNAs (miRNAs) are abnormally expressed in lung cancer tissues and play critical roles development progression. The aim this study is to identify the differentially miRNAs (DEMs) between non-small cell (NSCLC) normal tissues, evaluate prognostic value potential target gene functional enrichment DEMs. Materials Methods: We first downloaded high-throughput miRNA data from Cancer Genome Atlas Project (TCGA) database,...
Abstract Respiratory diseases like chronic obstructive pulmonary disease (COPD) are associated with the presence of particulate matter 2.5 (PM2.5) in air. In present study, effect synthesized ursolic acid derivatives on mice model PM2.5‐induced COPD was investigated vivo. The established by administration 25 μL PM2.5 suspension through intranasal route daily for 1 week. levels oxidative stress markers and inflammatory cytokines tumor necrosis factors‐α interleukin‐6 bronchoalveolar fluids...
Background and Objective: Triptolide (TP), one of the fat-soluble components extracted from Chinese medicinal herb Tripterygium wilfordii Hook F. (TWHF), possesses strong antitumor bioactivities, but its dose-dependent side effects restrict wide application. This study was designed to investigate whether inflammatory factors increased nontoxic dose TP on gastric cancer cells tried explore possible molecular mechanisms. Method: AGS MKN45 were treated with different doses TNF-α. Cell viability...
Long noncoding RNA (lncRNA) extracellular leucine rich repeat and fibronectin type III domain containing 1-antisense 1 (ELFN1-AS1) has been found to be upregulated in various tumors. However, the biological functions of ELFN1-AS1 gastric cancer (GC) are not entirely understood. In present study, expression levels ELFN1-AS1, miR-211-3p, TRIM29 determined using reverse transcription-quantitative PCR. Subsequently, CCK8, EdU, colony formation assays performed determine GC cell vitality. The...
Percutaneous radiofrequency thermocoagulation of the trigeminal ganglion through foramen ovale is a well-established procedure for treatment neuralgia (TN). However, this approach can be tricky when individual sub-branch nerve block required. We report our initial experience image-guided maxillary branch use rotundum. From February 2012 to 2015, we treated 25 patients with isolated TN branch. Radiofrequency rotundum was performed under fluoroscopy. pain evaluated using visual analogue scale...
In the past decade, considerable research efforts on gastric cancer (GC) have been expended, however, little advancement has made owing to lack of effective biomarkers and treatment options. Herein, we aimed examine levels expression, mutations, clinical relevance HMGs in GC provide sufficient scientific evidence for decision-making risk management.GC samples were obtained from The Cancer Genome Atlas (TCGA). University California Santa Cruz (UCSC) XENA, Human Protein (HPA), Gene Expression...
Cellular senescence acts as a barrier against tumorigenesis. The CD40L transgene, expressed in some tumor cells, not only becomes visible to antigen-presenting cells but also actively catalyzes its own termination. Here, we evaluated the effect of membrane-bound mutant form human (CD40L-M) on and senescence-associated secretory phenotype (SASP) non-small cell lung cancer (NSCLC).CD40 expression levels NSCLC lines A549/TR, A549/DDP H460 were examined by flow cytometry. Senescent tissues...
Abstract Comparatively less toxic and more tolerated, epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are recommendable for advanced non-small-cell lung cancer (NSCLC) patients with EGFR-sensitive mutations. Some EGFR wild-type specific biomarkers also show a response to the drug. TAZ is an oncogene closely associated therapeutic effect of EGFR-TKIs. However, this association remains be clarified. This study aimed clarify mechanism through which sensitizes NSCLC...
Although restoration of blood flow to an ischemic organ is essential prevent irreversible cellular injury, reperfusion may augment tissue injury in excess that produced by ischemia alone. So this experiment was designed study the protective effects and mechanism inactivated Lactobacillus (Lac) on myocardial ischemia-reperfusion (I-R) (MIRI). MIRI rat models were established ligation left anterior descending coronary artery for ~30 min then, 120 divided into control group, model Lac (106,...