A5010690202- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Welding Techniques and Residual Stresses
- Additive Manufacturing Materials and Processes
- High Entropy Alloys Studies
- Cardiac Valve Diseases and Treatments
- IoT and Edge/Fog Computing
- Cardiovascular Function and Risk Factors
- Endometriosis Research and Treatment
- Structural Engineering and Vibration Analysis
- Infrastructure Maintenance and Monitoring
- Infectious Aortic and Vascular Conditions
- 3D Printing in Biomedical Research
- RNA modifications and cancer
- Power Systems and Technologies
- Cardiac, Anesthesia and Surgical Outcomes
- Structural Health Monitoring Techniques
- Smart Grid Security and Resilience
- Cardiac and Coronary Surgery Techniques
- Privacy-Preserving Technologies in Data
- Single-cell and spatial transcriptomics
- Advanced Data and IoT Technologies
- Smart Grid and Power Systems
- Aortic Thrombus and Embolism
- ATP Synthase and ATPases Research
Green Chemistry
2025
Ningxia University
2025
South China Sea Institute Of Oceanology
2025
Institute of Oceanology
2025
Zhejiang Chinese Medical University
2025
Changzhou Institute of Technology
2022-2024
Hunan Xiangdian Test Research Institute (China)
2024
Fudan University
2020-2023
Zhongshan Hospital
2020-2023
State Grid Hunan Electric Power Company Limited
2023
Background Heart failure is a public health issue worldwide. However, no comprehensive study on the global burden of heart and its contributing causes has been reported. The present aimed to quantify burden, trends, inequalities globally. Methods Results data were extracted from Global Burden Diseases 2019 study. number cases, age‐standardized prevalence, years lived with disability in different locations 1990 presented compared. Joinpoint regression analysis was performed assess trends...
Abstract Objectives Lung cancer is still a disease with high morbidity and mortality in the world. Micro RNA s have been proven to act as an indispensable role reuse of multiple solid tumours. Although miR‐1258 plays vital suppressing metastasis breast gastric cancer, specific biological function non‐small‐cell lung remains unclear. Methods The differential expression NSCLC tissues corresponding paracancerous was detected by qRT ‐ PCR ISH . Flow cytometry CCK ‐8, EdU, tubule formation,...
Summary Bacterial flagella drive motility in many species, likely including the last bacterial common ancestor 1,2 . Knowledge of flagellar assembly and function has mainly come from studies Escherichia coli Salmonella enterica , which have simple motors 3–7 However, most flagellated bacteria possess complex with unique, species-specific adaptations whose mechanisms evolution remain largely unexplored 8–10 Here, we deploy a multidisciplinary approach to build near-complete model motor...
Central nervous system (CNS) involvement in diffuse large B-cell lymphoma (DLBCL) is relatively rare, occurring at a rate of approximately 5%. Primary CNS (CNS-DLBCL), subtype DLBCL, rare clinically but highly malignant and invasive. Its atypical clinical symptoms imaging features contribute to high misdiagnosis poor prognosis. Thus, early accurate diagnosis imperative for improving the patient's Cerebrospinal fluid (CSF) cytology, rapid convenient diagnostic method, plays crucial role...
Background: Bicuspid aortic valve (BAV) is the most common congenital cardiovascular disease in general population and frequently associated with development of thoracic aneurysm (TAA). There no effective strategy to intervene TAA progression due an incomplete understanding pathogenesis. Insufficiency NOTCH1 expression highly related BAV-TAA, but underlying mechanism remains be clarified. Methods: A comparative proteomics analysis was used explore biological differences between non-diseased...
Laser cladding repair is an advanced technology for repairing Invar alloy moulds; however, the influences of various processing parameters on quality moulds have yet to be determined. To explore optimisation laser parameters, analyses geometric features and microstructure layer were conducted. First, different powder feeding rates scanning speeds dilution rate substrate investigated by establishing a mathematical model power attenuation. Next, analysed. Finally, evaluated. At 2300 W, speed 3...
Ciprofloxacin use may be associated with adverse aortic events. However, the mechanism underlying effect of ciprofloxacin on progression thoracic aneurysm (TAA) is not well understood. Using an in vitro microphysiological model, we treated human smooth muscle cells (HASMCs) derived from patients bicuspid valve– or tricuspid valve–associated (BAV- TAV-associated) TAAs ciprofloxacin. TAA C57BL/6 mouse models were utilized to verify effects exposure. In real-time PCR, Western blotting, and RNA...
BackgroundThoracic aortic aneurysm (TAA) is the permanent dilation of thoracic wall that predisposes patients to lethal events such as dissection or rupture, for which effective medical therapy remains scarce. Human-relevant microphysiological models serve a promising tool in drug screening and discovery.MethodsWe developed dynamic, rhythmically stretching, three-dimensional model. Using patient-derived human smooth muscle cells (HAoSMCs), we tested biological features model compared them...
Colon cancer is one of the most common cancers, great progress was taken place in treatment colon cancer, however, prognostic assessment system remains lagging. Cell cycle plays a vital role whole procedure cancers. In this study, we firstly identified cell cycle-related genes specific cancer. Functional enrichment analysis proved our reliable. Furthermore, constructed robust signature based on genes. The AUC to predict overall survival 0.808, 0.807, and 0.831 at 1, 3, 5 years, respectively....
This study firstly developed a hiPSC-derived lineage-specific SMC-on-a-chip model and identified the segmental aortic heterogeneity. The can be used for disease modelling, drug testing personalised treatment.
Abstract The continuous energy input can lead to heat accumulation in the multi-pass lap laser cladding, which results a progressive increase dilution rate and deteriorates quality of cladding. Precisely controlling stability cladding is still challenging. In this study, we proposed deep-learning driven method for precisely Initially, relationship between power retracted via experiment-based finite element simulation. Subsequently, convolution neural network deep learning applied optimize...
Patients with bicuspid aortic valve (BAV) are at increased risk for ascending dilation (AAD). Our study was aimed systemically analyzing the expression profile and mechanism of circulating plasma exosomal microRNAs (miRNAs) related to BAV AAD.
Polymyxins antibiotics have become the first-line clinical drugs in treatment of refractory gram-negative bacterial infections. Currently, there is a lack studies on effect extracorporeal membrane oxygenation (ECMO) combined with continuous renal replacement therapy (CRRT) polymyxin concentrations. The purpose this report was to investigate changes plasma concentrations Colistin sulfate during ECMO and CRRT provide drug administration programs for critically ill patients receiving CRRT.In...