A5012899225- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Aortic aneurysm repair treatments
- Cardiac Structural Anomalies and Repair
- Colorectal Cancer Surgical Treatments
- Cardiac and Coronary Surgery Techniques
- Cardiomyopathy and Myosin Studies
- Cardiac, Anesthesia and Surgical Outcomes
- RNA Interference and Gene Delivery
- Tissue Engineering and Regenerative Medicine
- Congenital Heart Disease Studies
- Electrospun Nanofibers in Biomedical Applications
- Infectious Aortic and Vascular Conditions
- Connective tissue disorders research
- Infective Endocarditis Diagnosis and Management
- Cancer-related molecular mechanisms research
- Gastrointestinal motility and disorders
- MicroRNA in disease regulation
- 3D Printing in Biomedical Research
- Coronary Artery Anomalies
- Circular RNAs in diseases
- Hernia repair and management
- Mechanical Circulatory Support Devices
- Minimally Invasive Surgical Techniques
- Transplantation: Methods and Outcomes
Fudan University
2016-2025
Sun Yat-sen University
2016-2025
The First Affiliated Hospital, Sun Yat-sen University
2016-2025
Zhongshan Hospital
2016-2025
Xi'an Jiaotong University
2020-2024
China Southern Power Grid (China)
2023-2024
Guangxi Medical University
2013-2024
Harbin Institute of Technology
2023
E Ink (South Korea)
2023
Southwest Petroleum University
2023
Dietary fibers/probiotics may relieve constipation via optimizing gut microbiome, yet with limited trial-based evidences. We aimed to evaluate the effects of formulas dietary fibers or probiotics on functional symptoms, and identify modulations microbiota relevance. conducted a 4-week double-blinded randomized placebo-controlled trial in 250 adults constipation. Intervention: A: polydextrose; B: psyllium husk; C: wheat bran + D: Bifidobacterium animalis subsp. lactis HN019 Lacticaseibacillus...
Abstract Background KRAS gene is the most common type of mutation reported in colorectal cancer (CRC). mutation-mediated regulation immunophenotype and immune pathways CRC remains to be elucidated. Methods 535 patients were used compare expression immune-related genes (IRGs) abundance tumor-infiltrating cells (TIICs) tumor microenvironment between -mutant wild-type patients. An independent dataset included 566 cases an in-house RNA sequencing served as validation sets. consisting 335 analyze...
Polycystic ovary syndrome (PCOS) is the most common female endocrinopathy associated with both reproductive and metabolic disorders. Dehydroepiandrosterone (DHEA) currently used to induce a PCOS mouse model. High-fat diet (HFD) has been shown cause obesity infertility in mice. The possible effect of an HFD on phenotype DHEA-induced mice unknown. aim present study was investigate features fed normal chow or 60% HFD. Prepubertal C57BL/6 (age 25 days) were injected (s.c.) daily vehicle sesame...
Abstract Aims The incidence of acute aortic dissection (AAD) has been shown to have seasonal variation, but whether this variation can be explained by non-optimum ambient temperature and change between neighbouring days (TCN) is not clear. Methods results We performed a time-stratified case-crossover study in the Registry Aortic Dissection China covering 14 tertiary hospitals 11 cities from 2009 2019. A total 8182 cases AAD were included. Weather data at residential address matched nearby...
Ferroptosis, a form of programmed cell death induced by excess iron-dependent lipid peroxidation product accumulation, plays critical role in cancer. However, there are few reports about ferroptosis endometrial cancer (EC). This article explores the relationship between ferroptosis-related gene (FRG) expression and prognosis EC patients. One hundred thirty-five FRGs were obtained mining literature, retrieving GeneCards analyzing 552 malignant uterine corpus carcinoma (UCEC) samples, which...
The purpose of this study was to determine whether lysyl oxidase (LOX) is a useful marker metastasis in gastric cancer (GC) patients combination with tumor markers carcino-embryonic antigen (CEA), carbohydrate 724 (CA724), 19-9 (CA19-9), and 125 (CA125). There were 215 GC (67 without metastasis, 102 lymph node 46 peritoneal metastasis) who presented the Affiliated Cancer Hospital Guangxi Medical University between May 2009 November 2012 that enrolled study. LOX expression level serum...
Epigenetics may mediate the effects of environmental risk factors on disease, including heart disease. Thus, measuring DNA methylome offers opportunity to identify novel disease biomarkers and insights into mechanisms. The methylation landscape ascending aortic dissection (AD) bicuspid valve (BAV) with aneurysmal dilatation remain uncharacterized. present study aimed explore genome-wide underpinning these two diseases.We used Illumina 450k beadarrays analyse 21 aorta samples, 10 cases AD, 5...
Abstract HOTAIR , a well‐known long noncoding RNA s (lnc ), has been recognized to contribute the tumor metastasis in several tumors. But its role gastric cancer remains elusive. Here, we reported an increase promoted proliferation and of cell lines. The miR‐126 level was determined 15 paired primary tissues their adjacent noncancerous tissues. Over‐expression or downregulation conducted AGS BGC ‐823 cells investigate impact metastasis. Then dual luciferase reporter assay utilized study...
Background: Bicuspid aortic valve (BAV) is the most common congenital cardiovascular disease in general population and frequently associated with development of thoracic aneurysm (TAA). There no effective strategy to intervene TAA progression due an incomplete understanding pathogenesis. Insufficiency NOTCH1 expression highly related BAV-TAA, but underlying mechanism remains be clarified. Methods: A comparative proteomics analysis was used explore biological differences between non-diseased...
Acute diarrhea is a major cause of morbidity and mortality in children under five. Probiotics are beneficial for treating acute children, but unclear which specific probiotic the most effective. We performed Bayesian network meta-analysis to examine comparative effectiveness probiotics. By searching EMBASE, PubMed, Cochrane Library up 31 March 2021, randomized clinical trials (RCTs) on probiotics were included. Primary outcomes included duration lasting ≥2 days, secondary mean stool...
The aim of this study was to determine the airway exposure sugar and papermaking factory workers aflatoxin B1 (AFB1) explore potential association between AFB1 risk hepatocellular carcinoma (HCC) in a case-control study. Dust samples were collected from sugarcane bagasse warehouse, presser paper production workshops. Blood 181 workshop employees 203 controls who worked outside workshop. albumin adducts detected using double antibody sandwich enzyme-linked immunosorbent assay (ELISA). To HCC,...
Background Circadian rhythm disturbance is an independent risk factor for cancer. However, few studies have been reported on circadian related genes (CRGs) in cancer, so it important to further explore the impact of CRGs pan-cancer.
The overexpression of human telomerase reverse transcriptase (hTERT) has been associated with the invasion and metastasis colorectal cancer (CRC) received extensive attention, although underlying mechanism involved remains unclear. aim present study was to screen preliminarily validate new tumor‑suppressor microRNAs (miRNAs) that potentially inhibit hTERT expression assess its clinical significance. Screening for downregulated miRNAs in CRC tissues performed by retrieving analysing microRNA...
Induced pluripotent stem cells (iPSCs) have attracted keen interest in regenerative medicine. The generation of iPSCs from somatic can be achieved by the delivery defined transcription factor (Oct4, Sox2, Klf4, and c-Myc[OSKM]). However, most instances iPSC-generation been potentially harmful genome-integrating viral vectors. Here we report mouse embryonic fibroblasts (MEFs) using arginine-terminated 4 polyamidoamine (G4Arg) nanoparticles as a nonviral transfection vector for single plasmid...
Abstract Although left ventricular assist devices ( LVADs ) have been commonly used for patients with cardiogenic shock after acute myocardial infarction AMI ), their effects on post‐ prognosis remain to be elucidated. In this study, we aimed explore the of an LVAD LV remodeling and function at postinfarction stage in a swine model. was induced by ligation circumflex artery or its branches 120 min, followed min reperfusion. group n = 6), initiated 90 ischemia maintained support until...
Mesenchymal stem cell (MSC) transplantation by intramyocardial injection has been proposed as a promising therapy strategy for cardiac repair after myocardium infarction. However, low retention and survival of grafted MSCs hinder its further application. In this study, copolymer with N-isopropylacrylamide/acrylic acid/2-hydroxylethyl methacrylate-poly(ɛ-caprolactone) ratio 88:9.6:2.4 was bioconjugated type I collagen to construct novel injectable thermosensitive hydrogel. The biocompatible...
Abstract Introduction The Joint United Nations Programme on HIV/AIDS (UNAIDS) updated the 95‐95‐95 targets for HIV endgame in 2030. To achieve first target a timely manner, we investigate optimized strategy of resource allocation to maximize diagnosis 14 populations China. Methods We developed mathematical model by integrating epidemiological, demographical and behavioural data from 12 high‐risk two general evaluate impact various strategies testing incidence identified that maximizes number...