A5102896934- Gastric Cancer Management and Outcomes
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Surgical Treatments
- Wnt/β-catenin signaling in development and cancer
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Colorectal Cancer Treatments and Studies
- Growth Hormone and Insulin-like Growth Factors
- Neuroendocrine Tumor Research Advances
- Helicobacter pylori-related gastroenterology studies
- Cancer, Lipids, and Metabolism
- Data Mining Algorithms and Applications
- Esophageal and GI Pathology
- Advanced biosensing and bioanalysis techniques
- Cancer, Stress, Anesthesia, and Immune Response
- Viral-associated cancers and disorders
- Nausea and vomiting management
- Kruppel-like factors research
Guangxi Medical University
2015-2024
Tumor Hospital of Guangxi Medical University
2015-2023
Tianjin University
2022
City University of Hong Kong
2022
Wuhan General Hospital of Guangzhou
2017
// Lin-Hai Yan 1 , Zhi-Ning Chen 2 Li-Li 3 Jia 4 Wen-E Wei 5 Xian-Wei Mo Yu-Zhou Qin Yuan Lin Jian-Si Department of Gastrointestinal Surgery, Affiliated Tumor Hospital Guangxi Medical University, Nanning 530021, Zhuang Autonomous Region, China Pathology, Pharmacy, The People Image Center, Research, Correspondence to: Yan, email: lhyan@gxmu.edu.cn Keywords: gastric cancer, transcription factor E2F1 Received: March 16, 2016 Accepted: September 13, Published: 23, ABSTRACT Resistance to...
The overexpression of human telomerase reverse transcriptase (hTERT) has been associated with the invasion and metastasis colorectal cancer (CRC) received extensive attention, although underlying mechanism involved remains unclear. aim present study was to screen preliminarily validate new tumor‑suppressor microRNAs (miRNAs) that potentially inhibit hTERT expression assess its clinical significance. Screening for downregulated miRNAs in CRC tissues performed by retrieving analysing microRNA...
Gastric cancer (GC) is one of the most common gastrointestinal malignancies. Ferroptosis a new type peroxidation-driven and iron-dependent cell death. However, biological functions exact regulatory mechanisms ferroptosis in GC remain elusive. Here, we performed RNAi gene transfection, viability assay, lipid peroxidation reactive oxygen species (ROS) glutathione qRT-PCR, Western blotting, transmission electron microscopy (TEM) to study gastric cancer. The results revealed that silencing...
Introduction Curing locally advanced gastric cancer (GC) or gastro-oesophageal junction adenocarcinoma (GEJ) with surgery alone is challenging. Neoadjuvant chemotherapy (NCT) has become the standard treatment for patients GC/GEJ, and SOX most common neoadjuvant regimen in China. The generally good tolerability fruquintinib’s low potential drug–drug interaction suggest that it may be highly suitable combinations other antineoplastic therapies. A combination of fruquintinib, S-1 oxaliplatin...
The role and mechanism of hsa_circRNA_104433 in gastric cancer (GC) are further elucidated.
Gastric cancer is one of the death-related malignant tumors worldwide. It remains a challenge for diagnosis and treatment gastric cancer. Special AT-rich sequence-binding protein 2 (SATB2) new tumor suppressive gene plays important roles in many cancers. However, role SATB2 still unknown. In present study, we demonstrated that downregulation was associated with shortened survival patients Ectopic expression inhibited cell proliferation, colony formation, migration. Overexpression repressed...
Abstract To compared the ability of chewing gum or simo decoction (SMD) and acupuncture to reduce incidence postoperative ileus (POI) after colorectal cancer resection, patients with undergoing open laparoscopic resection were randomized receive SMD (n = 196), alone 197) no intervention starting on day 1 continuing for 5 consecutive days. Patients treated experienced significantly shorter hospital stay, time first flatus defecation than in other groups (all P < 0.05). Incidence grade I II...
Association of Coagulation factor V ( F5 ) polymorphisms with the occurrence many types cancers has been widely reported, but whether it is prognostic relevance in some remain to be resolved. The RNA‐sequencing dataset was downloaded from Cancer Genome Atlas (TCGA). potential genes predict survival time gastric cancer (GC) patients investigated using univariate and multivariate analysis whereas “Kaplan‐Meier plotter” (KM‐plotter) online tools were employed validate outcomes. TCGA data...
Background: Cohort studies have shown that neoadjuvant chemotherapy (NAC) is not associated with increased risk of postoperative complications and mortality as compared to upfront surgery (SURG). Objective: The aim this study was compare morbidity after NAC SURG. Patients methods: who underwent gastrectomy D2 lymphadenectomy for advanced gastric cancer (GC) between 2010 2017 were selected. impact on surgical safety investigated by using propensity score matching. Results: Three hundred...
Activation of the transcription factor E2F-1 gene is a negative event in dendritic cell (DC) maturation process. Down-regulation E2F1 causes immaturity DC thereby stopping antigen production which turn leads to inhibition immune responses. E2F-1-free stimulates NF-kB signaling pathway, leading activation monocytes and several other genes. In study, we report that down-regulation DCs promote anti-tumor response gastric cancer (GC) cells through novel mechanism. were isolated from peripheral...
Abstract While cadherin (CDH) genes are aberrantly expressed in cancers, the functions of CDH gastric cancer (GC) remain poorly understood. The clinical significance and molecular mechanisms GC were assessed this study. Data from a total 1226 patients included Cancer Genome Atlas (TCGA) Kaplan–Meier plotter database used to independently explore value application. TCGA RNA sequencing dataset was GC. Using enrichment analysis tools, found be related cell adhesion calcium ion binding function....
The prognostic value of histomorphologic regression in primary gastric and gastroesophageal cancers (GC/GEJ) has been previously established, however, the impact lymph node (LN) on survival still remains unclear.A prospectively maintained database was reviewed to identify cT4N+ after NAC (neoadjuvant chemotherapy). Patients were categorized into two groups based LN status: cN+/ypN0 (downstaged N0) cN+/ypN+ (persistent N+), long-term analyzed using Kaplan-Meier estimates.In total, 125...
Background: Tissue inhibitor of metalloproteinases (TIMP) gene family, including TIMP1, TIMP2, TIMP3 and TIMP4, was found to be correlated with serval cancers.Still the diagnostic prognostic study it in gastric cancer (GC) have few reports.Methods materials: In this study, expression clinical data were acquired from Cancer Gene Atlas (TCGA), function enrichment used by several databases for verifying known function.Operating characteristic (ROC) curves area under curve (AUC) assess...
Adrenergic receptor α1 (ADRA1) subfamily members, including ADRA1A, ADRA1B and ADRA1D, are understood to participate in cardiac disease benign prostatic hyperplasia. In addition, adrenergic signals cell pathways can promote the development of cancer. However, little is regarding associations between ADRA1 members gastric carcinoma (GC). The present study investigated prognostic value genes GC. Data from a total 379 patients with GC were obtained Cancer Genome Atlas Gene Expression Omnibus...
Armadillo gene subfamily members (ARMCX1-6) are well-known to regulate protein-protein interaction involved in nuclear transport, cellular connection, and transcription activation. Moreover, ARMCX signals on cell pathways also implicated carcinogenesis tumor progression. However, little is known about the associations of with gastric carcinoma. This study investigated prognostic value mRNA expression levels prognosis carcinoma (GC). We retrieved data a total 351 GC patients from TCGA...
Background: Imatinib has been regarded as the first successful synthetic small molecule targeting at blocking tyrosine kinase.Its high efficacy stabilized disease in above 80% of chronic myeloid leukemia (CML) patients over 10 years survival.Due to similar canceration gastrointestinal stromal tumor (GIST) CML, imatinib approved be used first-line treatment.Study design: Our retrospective study was proposed enroll 191 GIST with larger size (≥8 cm) who preoperative accepted from those direct...