A5023687151- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Cardiac Valve Diseases and Treatments
- Cardiovascular Issues in Pregnancy
- Cardiovascular Function and Risk Factors
- Infectious Aortic and Vascular Conditions
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Structural Anomalies and Repair
- 3D Printing in Biomedical Research
- Single-cell and spatial transcriptomics
- Anesthesia and Neurotoxicity Research
- Heart Failure Treatment and Management
- Cardiac and Coronary Surgery Techniques
- Atrial Fibrillation Management and Outcomes
- Climate Change and Health Impacts
- Energy, Environment, and Transportation Policies
- Air Quality and Health Impacts
- Nitric Oxide and Endothelin Effects
- Innovative Microfluidic and Catalytic Techniques Innovation
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cerebrovascular and Carotid Artery Diseases
- Congenital Heart Disease Studies
- Atherosclerosis and Cardiovascular Diseases
- Anesthesia and Sedative Agents
Xiangya Hospital Central South University
2023-2025
Central South University
2023-2025
Sun Yat-sen University
2021-2023
The First Affiliated Hospital, Sun Yat-sen University
2021-2023
Zhongshan Hospital
2021-2023
Fudan University
2021-2023
E Ink (South Korea)
2023
Shanghai Medical College of Fudan University
2022
Shanghai Institute of Hematology
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2019
Background Heart failure is a public health issue worldwide. However, no comprehensive study on the global burden of heart and its contributing causes has been reported. The present aimed to quantify burden, trends, inequalities globally. Methods Results data were extracted from Global Burden Diseases 2019 study. number cases, age‐standardized prevalence, years lived with disability in different locations 1990 presented compared. Joinpoint regression analysis was performed assess trends...
Coronary artery disease (CAD) remains a leading global cause of mortality. The expression small ubiquitin-like modifier 1 (SUMO-1) is reduced in heart failure. However, the mechanisms underlying its modification CAD remain underexplored. This study sought to identify SUMOylation-related biomarkers and elucidate potential pathogenesis. analyzed three datasets (GSE42148, GSE23561, GSE121893) alongside 187 genes (SRGs). overlap between differentially expressed (DEGs) SRGs was used (DE-SRGs)....
BackgroundThoracic aortic aneurysm (TAA) is the permanent dilation of thoracic wall that predisposes patients to lethal events such as dissection or rupture, for which effective medical therapy remains scarce. Human-relevant microphysiological models serve a promising tool in drug screening and discovery.MethodsWe developed dynamic, rhythmically stretching, three-dimensional model. Using patient-derived human smooth muscle cells (HAoSMCs), we tested biological features model compared them...
Ciprofloxacin use may be associated with adverse aortic events. However, the mechanism underlying effect of ciprofloxacin on progression thoracic aneurysm (TAA) is not well understood. Using an in vitro microphysiological model, we treated human smooth muscle cells (HASMCs) derived from patients bicuspid valve– or tricuspid valve–associated (BAV- TAV-associated) TAAs ciprofloxacin. TAA C57BL/6 mouse models were utilized to verify effects exposure. In real-time PCR, Western blotting, and RNA...
This study firstly developed a hiPSC-derived lineage-specific SMC-on-a-chip model and identified the segmental aortic heterogeneity. The can be used for disease modelling, drug testing personalised treatment.
Abstract OBJECTIVES The causal association between immune cell traits and aortic aneurysm remains unknown. METHODS We performed a bidirectional two-sample Mendelian randomization analysis to explore the causality 731 characteristics risk of abdominal thoracic aneurysms through publicly available genetic data, respectively. To examine heterogeneity horizontal pleiotropy, Cochran’s Q test MR-Egger intercept were utilized. Additionally, multivariable meta-analysis in further analysis. RESULTS...
The occurrence and development of aortic aneurysms are accompanied by senescence human smooth muscle cells (HASMCs). Because the mechanism HASMC has not been fully elucidated, efficacy various antisenescence treatments varies. Decreased nicotinamide adenine dinucleotide (NAD + ) levels one mechanisms cell senescence, there is a lack evidence on whether increasing NAD could alleviate further retard progression aneurysms.We constructed an HASMC-based organ-on-a-chip microphysiological model....
The impact of new-onset atrial fibrillation (AF) after aortic valve (AV) surgery on mid- and long-term outcomes is under debate. Here, we sought to follow up heart rhythms AV surgery, evaluate the mid-term prognosis effectiveness treatment for patients with AF.This single-center cohort study included 978 consecutive (median age, 59 years; male, 68.5%) who underwent surgical procedures between 2017 2018. All postoperative AF were treated Class III antiarrhythmic drugs or without electrical...
Purpose: To investigate the feasibility of a pre-targeted imaging strategy based on cycloaddition between 1,2,4,5-terazine (Tz) and trans-cyclooctene (TCO) for evaluating CD11b expression in inflammatory aortic aneurysm (AA) using single photon emission computed tomography/computed tomography (SPECT/CT). Methods: C57BL/6J mice were fed β-aminopropionitrile (1 g/kg/day) 4 weeks to establish AA models. Anti-CD11b-TCO was synthesized 99m Tc-HYNIC-PEG 11 -Tz designed SPECT/CT. The affinity...
Conventional two-dimensional cell culture techniques and animal models have been used in the study of human thoracic aortic aneurysm dissection (TAAD). However, TAAD sometimes cannot be characterized by models. There is an apparent species gap between clinical studies experiments that may hinder discovery therapeutic drugs. In contrast, conventional model unable to simulate vivo biomechanical stimuli. To this end, microfabrication microfluidic developed greatly recent years, providing novel...
Abstract Background Coronary artery disease (CAD) is a multifactorial cardiovascular that causes high mortality worldwide. Cuproptosis newly discovered method of programmed cell death, but it unclear whether involved in the development CAD. Methods GSE180081 was downloaded from GEO database and genes were differentially expressed controls patients with CAD identified. These clustered according to cuproptosis gene set, identify related genes. The intersection two sets used relevant diagnosis...
The purpose of the current treatment about aortic intramural hematoma(IMH) is to prevent rupture or conversion typical dissection. Due different influence human race, IMH type, severity and progression factors on this disease, management remains controversial. Therefore, we reviewed therapy Aortic hematoma(IMH). And provided a reference for further study disease by analyzing comparing relatively radical strategies close follow-up treatment(wait-and-watch strategy) strategies.
Objective Big endothelin-1(big ET-1) is associated with the prognosis of various cardiovascular diseases. This study to explore predictive value plasma big ET-1 level for long-term outcome after mitral valvuloplasty in patients moderate severe chronic ischemic insufficiency. Methods A total 142 consecutive regurgitation who underwent coronary artery bypass grafting and were enrolled at our center from January 2009 December 2015. The clinical baseline data collected recorded. All...
Aortic intramural hematoma(IMH) is an acute and lethal disease, comprises the aortic syndrome with dissection penetrating ulcer. There are considerable controversies about definition, etiology, management of IMH, therefore we review current status diagnosis IMH. Key words: Acute syndromes; Aortic hematoma; Aortic
Conventional two-dimensional cell culture techniques and animal models have been used in the study of human thoracic aortic aneurysm dissection (TAAD). However, TAAD sometimes cannot be characterized by models. There is an apparent species gap between clinical studies experiments that may hinder discovery therapeutic drugs. In contrast, conventional model unable to simulate vivo biomechanical stimuli. To this end, microfabrication microfluidic developed greatly recent years, providing novel...
Background: Thoracic aortic aneurysm (TAA) is a multifactorial disease that can progress into dissection or rupture. The use of ciprofloxacin could be associated with adverse events. However, the mechanism underlying effect on progression TAA not yet well understood.Methods: Using microfluidic organ-on-a-chip technology, primary human smooth muscle cells (HASMCs) were treated and compared those isolated from patients TAAs bicuspid valve (BAV) tricuspid (TAV).Findings: In vitro...