A5101698770- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Neurological Disease Mechanisms and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Catalytic C–H Functionalization Methods
- Metabolomics and Mass Spectrometry Studies
- Single-cell and spatial transcriptomics
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Genomics and Phylogenetic Studies
- Genetic Associations and Epidemiology
- Cyclopropane Reaction Mechanisms
- China's Ethnic Minorities and Relations
- Advanced DC-DC Converters
- Neurosurgical Procedures and Complications
- Muscle and Compartmental Disorders
- Synthesis and Catalytic Reactions
- Plant Gene Expression Analysis
- Gene expression and cancer classification
- Catalytic Alkyne Reactions
- Eurasian Exchange Networks
- 14-3-3 protein interactions
Sichuan Academy of Agricultural Sciences
2025
Sericultural Research Institute
2025
The Fifth People’s Hospital of Suzhou
2025
Shanghai Chest Hospital
2024
Shanghai Jiao Tong University
2021-2024
Fudan University
2010-2023
Zhongshan Hospital
2022-2023
The First Affiliated Hospital, Sun Yat-sen University
2022
Sun Yat-sen University
2022
Shanghai Institute of Hematology
2022
Hepatocellular carcinoma (HCC) is one of the most aggressive and heterogeneous cancers worldwide. Herein, we demonstrate KIF4A (Chromosome-associated kinesin KIF4A) as a potential biomarker, up-regulated in samples HCC. The expression level tumor tissue significantly associated with survival time, significant correlation between clinical information stage, metastasis dimension was observed. We further measured proliferation migration ability two HCC cell lines, HCC-LM3 PLC/PRF/5, following...
Hepatocellular carcinoma (HCC) is among the most malignant cancers worldwide, lacking biomarkers for subtyping and reliable prognostication. Herein, we report a novel biomarker, NEU1 (neuraminidase 1), up-regulated in samples of HCC. The diagnostic value was evaluated by ROC, AUC (area under curve) reached 0.87 0.96 two independent datasets, respectively. survival differences HCC patients with high or low expression were statistically significant, significant correlation between clinical...
Understanding the global transcriptomic and metabolic changes during mulberry growth development is essential for enhancing fruit quality optimizing breeding strategies. By integrating phenotypic, metabolomic, data across 18 developmental ripening stages of Da10 fruit, a map gene expression was generated. Analysis revealed gradual progression morphological, metabolic, transcriptional throughout phases. In this study, new transcriptome transition, which highly related to stress resistance,...
Mitophagy is an essential cellular process that conserved and crucial for maintaining balance by selectively eliminating malfunctioning mitochondria. However, there still limited knowledge regarding the influence of mitophagy-related genes (MRGs) on prognosis response to treatment triple-negative breast cancer (TNBC). In here, TCGA GEO databases were used acquire transcriptomic clinical information patients with TNBC, correspondingly. Using LASSO multivariable Cox regression analyses, a risk...
Hepatocellular carcinoma is one of the most heterogeneous cancers, as reflected by its multiple grades and difficulty to subtype. In this study, we integrated copy number variation, DNA methylation, mRNA, miRNA data with developed "cluster cluster" method classified 256 HCC samples from TCGA (The Cancer Genome Atlas) into five major subgroups (S1-S5). We observed that classification was associated specific mutations protein expression, detected each subgroup had distinct molecular...
An isolated dc-dc series-resonant converter that is controlled by a combination of variable-frequency and secondary-side-switch delay-time control employed as the output stage on-board charger module (OBCM) operates with wide battery-voltage range. The which implemented modulation secondary-side switches used to assist conventional variable-switching-frequency primary reduce switching-frequency By substantially reducing range utilizing gallium nitride (GaN) switches, overall operating...
Peroxisome proliferator-activated receptors (PPARs) and part of their target genes have been reported to be related the progression hepatocellular carcinoma (HCC). The prognosis HCC is not optimistic, more accurate prognostic markers are needed. This study focused on discovering potential from PPAR-related gene set. mRNA data clinical information were collected TCGA GEO platforms. Univariate Cox lasso regression analyses used screen HCC. Three (MMP1, HMGCS2, SLC27A5) involved in PPAR...
Abstract Ovarian cancer (OC) is the most lethal gynaecological with genomic complexity and extensive heterogeneity. This study aimed to characterize molecular features of OC based on gene expression profile 2752 previously characterized metabolism‐relevant genes provide new strategies improve clinical status patients OC. Finally, three subtypes (C1, C2 C3) were identified. The subtype displayed worst prognosis, upregulated immune‐cell infiltration level immune checkpoint genes, lower burden...
This study firstly developed a hiPSC-derived lineage-specific SMC-on-a-chip model and identified the segmental aortic heterogeneity. The can be used for disease modelling, drug testing personalised treatment.
Abstract Background Lung squamous cell carcinoma (LUSC) is a major subtype of non-small lung cancer with high mortality rate. Identifying causal plasma proteins associated LUSC could provide new insights into the pathophysiology disease and potential therapeutic targets. This study aimed to identify causally linked risk using proteome-wide Mendelian randomization (MR) colocalization analyses. Methods Proteome-wide MR analysis was conducted data from UK Biobank Pharma Proteomics Project...
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death, and prognosis varies due to its high heterogeneity, systematic evaluation HCC mainly based on genomic transcriptomic features, metabolomics-based classification has yet be reported. Here we performed RNA-seq 50 paired samples metabolomics analysis 72 both normal tumor tissues from patients. Through unsupervised hierarchical cluster with train test data sets, metabolic gene expression signatures were...
Accumulated evidence highlights the role of metabolites in cancer diagnosis. However, diagnosis hepatocellular carcinoma (HCC), especially its early diagnosis, is still very difficult. The main purposes study are to explore comprehensive characteristic HCC through an integrated nontargeted metabolomics and transcriptomics approach evaluate diagnostic value some metabolic changes HCC.Dysregulated pathways were identified by analysis 72 pairs matched liver tissues, including tissue (HCT)...
Epigenetic changes are potentially important for the ontogeny and progression of tumors but not usually studied because complexity analyzing transcript regulation resulting from epigenetic alterations. Prostate cancer (PCa) is characterized by variable clinical manifestations frequently unpredictable outcomes. We performed an expression quantitative trait loci (eQTL) analysis to identify genomic regions that regulate gene in PCa identified a relationship between DNA methylation information....
Despite the scRNA-seq analytic algorithms developed, their performance for cell clustering cannot be quantified due to unknown “true” clusters. Referencing transcriptomic heterogeneity of clusters, a mRNA number matrix individuals was defined as ground truth. Based on and actual data generation procedure, simulation program (SSCRNA) raw developed. Subsequently, consistency between simulated real evaluated. Furthermore, impact sequencing depth analyses cluster accuracy quantified. As result,...