A5029347163- Angiogenesis and VEGF in Cancer
- Inflammatory mediators and NSAID effects
- Cancer Immunotherapy and Biomarkers
- Immune Response and Inflammation
- Pancreatic and Hepatic Oncology Research
- Peroxisome Proliferator-Activated Receptors
- Telomeres, Telomerase, and Senescence
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- Cancer, Stress, Anesthesia, and Immune Response
- Wound Healing and Treatments
- RNA modifications and cancer
- Neurological Disease Mechanisms and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal cell carcinoma treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Microfluidic and Capillary Electrophoresis Applications
- Nuclear Receptors and Signaling
- Organic Electronics and Photovoltaics
- CAR-T cell therapy research
- Tryptophan and brain disorders
- Gastric Cancer Management and Outcomes
- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Diabetic Foot Ulcer Assessment and Management
Sir Run Run Shaw Hospital
2022-2024
Zhejiang University
2022-2024
Sichuan University
2024
Anhui Medical University
2022-2023
First Affiliated Hospital of Anhui Medical University
2022-2023
Huawei Technologies (China)
2023
Wannan Medical College
2019-2021
Zhejiang Academy of Medical Sciences
2019
Abstract Background Immunotherapy‐antiangiogenesis combination therapy has achieved excellent survival outcomes in hepatocellular carcinoma (HCC) clinical trials. However, the for HCC outside trials is not well studied, and predictive factors are lacking. Here, we retrospectively analyzed efficacy safety of immunotherapy‐antiangiogenesis unresectable patients a real‐world setting. Methods We conducted four‐center, retrospective study who received programmed death 1 ( PD‐1) inhibitor...
Osteosarcoma is an aggressive malignant bone sarcoma worldwide. A causal gene network with specific functions underlying both the development and progression of OS was still unclear. Here we firstly identified differentially expressed genes (DEGs) between control samples, then defined hub top clusters in protein-protein interaction (PPI) these DEGs. By focusing on TYROBP 1 cluster, a conserved co-expression identified. Then effect overall survival analyzed. Gene Ontology (GO), Kyoto...
Ischemic stroke, the third leading cause of disability globally, imposes a notable economic burden. Tetrandrine (Tet), which has been widely used clinically, exhibits potential protective effects against stroke. However, there little pre‑clinical research to evaluate therapeutic Tet on The present study investigated beneficial effect ischemia‑reperfusion (I/R) injury and its underlying mechanism in rats. Rats were subjected occlusion middle cerebral artery, then treated with (30 mg/kg/day,...
In the past decade, considerable research efforts on gastric cancer (GC) have been expended, however, little advancement has made owing to lack of effective biomarkers and treatment options. Herein, we aimed examine levels expression, mutations, clinical relevance HMGs in GC provide sufficient scientific evidence for decision-making risk management.GC samples were obtained from The Cancer Genome Atlas (TCGA). University California Santa Cruz (UCSC) XENA, Human Protein (HPA), Gene Expression...
Recent studies have shown that the high incidence and low cure rate of hepatocellular carcinoma (HCC) not improved significantly. Surgery liver transplantation are mainstays prolonging survival HCC patients. However, surgical resection patients is very low, even after radical resection, recurrence at 5 years postoperatively remains prognosis poor, so more treatment options urgently needed. Increasing evidence suggests cellular senescence only related to cancer development but may also be one...
Endothelial precursor cell (EPC) dysfunction is one of the risk factors for diabetes mellitus (DM) which results in delayed wound healing. Rosiglitazone (RSG) a frequently prescribed oral glucose-lowering drug. Previous studies have shown positive effects RSG on ameliorating EPC diabetic patients. Interestingly, knowledge about with regard to healing process caused by DM scarce. Therefore, this study, we investigated possible actions and related mechanisms involved db/db mice.Db/db mice...
The active form of vitamin D3, i.e., 1,25(OH)2D3, exerts an anti-inflammatory effect on the immune system, especially macrophage-mediated innate immunity. In a previous study, we identified 1,25(OH)2D3-responsive and D receptor (VDR)-bound super-enhancer regions in THP-1 cells. Herein, examined transcriptional regulation ArfGAP with SH3 Domain, Ankyrin Repeat PH Domain 2 (ASAP2) (encoding GTPase-activating protein) by 1,25(OH)2D3 through top-ranked VDR-bound region first intron ASAP2...
Hot embossing is a manufacturing technique used to create microchannels on polymer substrates. In recent years, microchannel fabrication technology based hot has attracted considerable attention due its convenience and low cost. A new evaluation method of microchannels, as well an approach obtaining optimal conditions the Taguchi method, proposed in this paper fabricate precise for flexible proton-exchange membrane fuel cell (PEMFC). Our self-made system can be assorted types micro-channel...
Immunotherapy and antiangiogenic therapy have shown promising clinical activity in patients with advanced biliary tract cancer (BTC) trials. As the combination of these two treatments for BTC is not well studied real world, present study retrospectively analyzed outcomes unresectable who received immunotherapy-antiangiogenesis a real-world setting. A three-center, retrospective was performed on programmed death 1 inhibitor agent between March 26, 2019 November 1, 2021 China. In total, 68...
Abstract Indoleamine-2,3-dioxygenase (IDO1) is an immune regulatory enzyme that oxidizes tryptophan to kynurenine. IDO1 overexpressed in numerous tumor cells block T-cell activation, induce apoptosis and increase T cells, which create environment tumor-specific cytotoxic lymphocytes are no longer able attack a patient's cancer cells. inhibition reverses the suppression at site allows generation of effective anticancer response. Preclinical clinical studies have shown inhibitors response...
Abstract Recent studies have shown no significant improvement in the high incidence and low cure rates of hepatocellular carcinoma (HCC). Surgery liver transplantation are primary means prolonging survival patients with HCC. however, HCC surgical resection rates, even when radical is obtained, 5-year postoperative recurrence rate remains high, prognosis poor, additional therapeutic options urgently needed. There increasing evidence that cellular senescence associated human cancers. The...
Abstract The cancer drug discovery field is experiencing unprecedented revolution accompanied by growing excitement from researchers, developers, patients and investors, partly due to recent clinical success of immunotherapy. Human immune defense system comprises both innate adaptive pathways. All the targets drugged recently approved immunotherapeutic agents including checkpoint proteins PD-1, PD-L1 CTLA-4 function in In contrast, involved pathway have not matured regulatory approval for...
Abstract The innate immune system has emerged as one of the major pathways for drug discovery focusing on cancer immunotherapy. TLR8 plays a crucial role in activating immunity and facilitates adaptive thereby exerting potent immune-mediated anticancer activity. We previously presented preliminary characterization novel agonist DN-A1 (Abstract 2995, AACR Annual Meeting 2017). In present study, we carried out further comprehensive comparative preclinical study motolimod, only selective...
Toll like receptors (TLRs) have been a recent focus of drug discovery for cancer immunotherapy. TLRs play crucial role in bridging innate and adaptive immunity. TLR8 is distinguished from other by its functions reversing regulatory T (Treg) cell myeloid derived suppressor (MDSC)'s immune suppression effects. Treg MDSCs induce an immunosuppressive microenvironment that major cause failed tumor Therefore, activation can exert potent immune-mediated anticancer activity. We discovered novel...