A5045484275- Inflammasome and immune disorders
- Immune Response and Inflammation
- Inflammation biomarkers and pathways
- Plant Stress Responses and Tolerance
- Natural Compounds in Disease Treatment
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Plant Molecular Biology Research
- MicroRNA in disease regulation
- Respiratory Support and Mechanisms
- Plant nutrient uptake and metabolism
- Immune cells in cancer
- Gout, Hyperuricemia, Uric Acid
- Circular RNAs in diseases
Beijing Proteome Research Center
2024
Harbin Medical University
2014-2024
Daqing City People's Hospital
2024
Hebei Normal University
2021
Second Affiliated Hospital of Harbin Medical University
2017
Diabetic cardiomyopathy is a common cardiac condition in patients with diabetes mellitus, which can result hypertrophy and subsequent heart failure, associated pyroptosis, the pro-inflammatory programmed cell death. MicroRNAs (miRNAs), small endogenous non-coding RNAs, have been shown to be involved diabetic cardiomyopathy. However, whether miRNAs regulate pyroptosis remains unknown. Our study revealed that mir-30d expression was substantially increased streptozotocin (STZ)-induced rats...
Significance Upon brassinosteroid (BR) treatment, BRASSINAZOLE RESISTANT1 (BZR1) is dephosphorylated and accumulate in the nucleus. However, it was unclear whether these two processes are interdependent. Here, we show that BR signaling first recruits phosphorylated BZR1 to nucleus where by protein phosphatase 2A (PP2A). constitutively degraded via a BR- 26S proteosome–independent mechanism; however, treatment activates different proteosome–dependent pathway increases turnover rate. These...
BackgroundCardiac remodeling is a common pathological feature in many cardiac diseases, characterized by hypertrophy and fibrosis. Triptolide (TP) natural compound derived from Tripterygium wilfordii Hook F. However, the related mechanism of it has not been fully understood.Methods resultsTransverse aortic constriction (TAC)-induced hypertrophic mouse model angiotensin II (Ang II)-induced cardiomyocytes were performed. Firstly, results indicate that TP can improve function, decreased...
Epstein-Barr virus (EBV) is a well-documented aetiological factor for multiple sclerosis (MS). EBV encodes at least 44 microRNAs (miRNAs) that are readily detectable in the circulation of human. Previous studies have demonstrated EBV-encoded miRNAs regulate host immune response and may serve as biomarkers EBV-associated diseases. However, roles MS still unknown. To fill gap, we conducted comprehensive profiling mature 30 relapsing-remitting (RRMS) patients relapse matched healthy controls....
Acute lung injury (ALI) and its subsequent progression to acute respiratory distress syndrome (ARDS) are severe conditions. They marked by rapid function deterioration extensive pulmonary inflammation, often resulting in critical patient outcomes. Alveolar macrophages (AMs) monocyte-derived (MDMs) two distinct subsets of present the alveoli during ALI. Both mediators inflammation. Our study examined interplay between AMs MDMs inflammatory environment ALI/ARDS.