Epithelial ovarian cancer (EOC) is a that affects the female reproductive system and highly lethal. It poses significant challenges in terms of treatment often has poor prognosis. In recent years, with advent PARPi, entered new stage full-process management. Although more drugs have been approved, therapeutic effect PARPi still very limited. With rapid development PD-1/PD-L1, CTLA-4, oncolytic viruses, vaccines, adoptive cell therapy, etc., tumor immunotherapy provided opportunities for...

This brief presents a fast-locking multiphase closed-loop delay-locked loop (DLL). The proposed DLL employs novel rapid-tracking time-to-digital converter that spends only two clock cycles to generate fine codes. greatly reduces the fine-locking time and hence total locking goes down eight input reference cycles, shortened by 80%-95% compared with previously reported architectures. Fabricated in 130-nm technology, operates at 80-450 MHz. In addition, measured rms peak-to-peak jitters 180 MHz...

A high-speed CMOS TSPC divide-by-16/17 dual modulus prescaler is proposed. The speed of the improved in two aspects. First, by adopting a new pseudo divide-by-2/3 prescaler, minimum working period effectively reduced half NOR gate's delay. Second, changing connection D-Flip-Flops, further an inverter's Simulation results show that maximum operating frequency proposed circuit ~40% compared with conventional circuit. Fabricated 0.18-μm process, capable up to 5.8 GHz. power consumption 2.6 mW...

A fast-locking digital delay-locked loop (DLL) is presented in this paper. By adopting a novel high resolution Time-to-Digital Converter (TDC), the time for generating fine-tuned codes reduced to two clock cycles. Thus total locking greatly 8 input reference cycles and remarkably shortened by 80% 94.6% compared previous closed-loop architectures. The proposed DLL has been fabricated 0.13μm CMOS technology operates from 80MHz 450MHz. measured RMS peak-to-peak jitters are 2.3ps 10ps respectively.

A novel structure of CMOS low voltage bandgap reference, called "Subtracting BandGap Reference" (SBGR), is proposed. In this work, the extremely small temperature coefficient obtained by subtracting two Complementary To Absolute Temperature (CTAT) currents with same but different magnitude. The subtraction CTAT which have similar characteristics leads to coefficient. Simulation results show that new SBGR circuit achieves a three times lower than conventional reference.

In this paper, an improved V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">GS</sub> /R reference circuit capable of generating both voltage and current references is proposed. Compared with the conventional which can only provide a temperature independent reference, new generates without any extra cost on power dissipation. Simulation results show that proposed gives 585 mV Temperature Coefficient (TC) 4.9 ppm/°C 744 nA coefficient 30 from...

The existing research shows that falls account for a significant proportion of safety accidents. At the same time, as many countries enter an aging society, have increasingly become non-negligible issue affecting lives and health elderly. To address current problems human fall detection, we propose to extract skeleton model based on YoloX-s in combination with Lightweight OpenPose. This can identify by difference values angle change's rate between key points neck knees. results demonstrate...

A multimode DLL with trade-off between multiphase and static phase error is presented. By adopting a control circuit to regroup the delay line, better performance can be achieved while reducing number of output phases. The accomplishes three operation modes: mode1 four-phase output, mode2 two-phase performance, mode3 only one-phase but best performance. proposed has been fabricated in 0.13 μm CMOS technology measurement results show that errors mode1, are −18.2 ps, 11.8 ps −6:44...

This paper presents a novel dual-band quadrature voltage controlled oscillator (VCO) with the gain proportional to oscillation frequency. Frequency synthesizers this VCO can reduce bandwidth fluctuation over all frequency ranges without compensation or calibration. Besides original switched capacitor array, an extra varactor array is adopted for implementation of proposed VCO. The tuning technique changing values and at same ratio also derived. For verification purposes, 2.5 G/3.5 G...

This paper proposes a baseband circuit for wake-up receivers with double-mode detection and enhanced sensitivity robustness use in the electronic toll collection system. A method, including amplitude frequency detection, is proposed to reject interference reduce false wake-ups. An improved closed-loop band-pass filter DC offset cancellation technique are also newly introduced enhance robustness. The fabricated TSMC 0.18 μm 3.3 V CMOS technology an area of 0.12 mm2. Measurement results show...

Infared ship recognition has many applications in port supervision and management. However, when the imaging distance is long or target changes are obvious, it difficult to achieve accurate detection by traditional methods. In this paper, we designed a single step cascade neural network that consists of three parts: feature extraction module, scale transform module classification regression module. Firstly, VGG used extract different level features images. Then fuse high-level low-level...

Improving the quality of teachers is key to development schools and teaching. There widespread agreement among researchers practitioners that are most significant component in education schools, it therefore obvious supporting professional makes a contribution toward improving educational systems learning outcomes students. "School-based training" refers type in-school vocational training initiated, organized planned by with goal teachers' teaching research capabilities, as well promote...

Abstract Background: Liver fibrosis is a common consequence of chronic liver diseases resulting from multiple etiologies. Early clinical application shows that Ruangan Xiaoji Decoction (RGXJD) has very obvious effect on the treatment fibrosis. However, mechanism RGXJD cures requires further elucidation. Methods: In this work, therapeutic CCl 4 -induced fibroses serum and tissue metabolite changes in rat was analyzed by 1 H-NMR metabolomics. Meanwhile, histopathology examinations chemistry...