A5047847588- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Ovarian cancer diagnosis and treatment
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Cancer-related molecular mechanisms research
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Cancer Risks and Factors
- Gestational Trophoblastic Disease Studies
- Gynecological conditions and treatments
- PARP inhibition in cancer therapy
- Lung Cancer Research Studies
- Genital Health and Disease
- MicroRNA in disease regulation
- Folate and B Vitamins Research
- Sarcoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Seismic Waves and Analysis
- Cancer Cells and Metastasis
- Geophysical and Geoelectrical Methods
- RNA modifications and cancer
- Lymphoma Diagnosis and Treatment
- Circular RNAs in diseases
- Gastric Cancer Management and Outcomes
Women's Hospital, School of Medicine, Zhejiang University
2015-2024
XinHua Hospital
2024
Zhejiang University
2007-2024
Shanghai Jiao Tong University
2024
Zhejiang Cancer Hospital
2023
Second Hospital of Shanxi Medical University
2020
Blood Center of Zhejiang Province
2018-2020
Jilin University
2014-2020
Shanxi Medical University
2020
Shandong University of Science and Technology
2020
Reduced miR-34a expression is associated with high-risk human papillomavirus (HR-HPV) infection and cervical cancer. Whether the reduction of induced by HR-HPV E6 occurs in precancerous lesions, even before morphologic change, still uncertain. Our study aimed to ascertain possibility pri-miR-34a involved development lesions explore mechanism altered HPV-16 E6.The levels were examined different tissues, including normal epithelium (n = 32) or without infection, intraepithelial neoplasia (CIN)...
Learning Objective Evaluate the changes in prevalence and clinical characteristics of cervical cancer China.
Abstract Introduction Exosomal microRNA (miRNA) as a mediator of intercellular communication plays an essential part in tumor‐relevant angiogenesis. Therapy against angiogenesis has been demonstrated to have remarkable antitumor efficacy various malignancies, but not expected ovarian cancer. Methods Exosomes were isolated by ultracentrifugation. miRNA sequencing and gene function experiments used identify the differential expressed miRNAs exosomes their mRNA targets. SKOV3 cell line that...
ObjectiveNeoadjuvant chemotherapy (NACT) for cervical cancer still remains controversial. NACT was evaluated to establish selection criteria.MethodsA matched-case comparison designed the group (n = 707) and primary surgery treatment (PST; n investigate short-term responses high/intermediate risk factors (HRFs/IRFs). The 5-year disease-free survival (DFS) overall (OS) rates were stratified by response, HRFs/IRFs, International Federation of Gynecology Obstetrics (FIGO) stage tumour size,...
PURPOSE Lenvatinib plus pembrolizumab (len + pembro) significantly improved progression-free survival (PFS) and overall (OS) versus chemotherapy in previously treated advanced or recurrent endometrial cancer (aEC) the phase III Study 309/KEYNOTE-775. We report results from III, randomized, open-label European Network of Gynaecological Oncological Trial-en9/LEAP-001 study (ClinicalTrials.gov identifier: NCT03884101 ) that evaluated len pembro first-line aEC. METHODS Patients with stage to IV...
Abstract Background The prospective phase III multi-centre L-MOCA trial (NCT03534453) has demonstrated the encouraging efficacy and manageable safety profile of olaparib maintenance therapy in Asian (mainly Chinese) patients with platinum-sensitive relapsed ovarian cancer (PSROC). In this study, we report preplanned exploratory biomarker analysis trial, which investigated effects homologous recombination deficiency (HRD) programmed cell death ligand 1 (PD-L1) expression on efficacy. Methods...
Abstract Ovarian cancer is an aggressive gynecological tumor usually diagnosed with widespread metastases. Extracellular vesicles (EVs), though recognized as important mediators of metastasis, have received limited attention into their specific functions via the mRNA profiling. Here it reported elevated expression and selective enrichment INAVA in both plasma‐ tissue‐derived EVs from ovarian patients, which positively correlated distant metastasis poor prognosis. Functionally, mRNA, upon...
Cervical cancer is the most common cause of cancer-related deaths in women from developing countries. Identification novel prognostic predictors or therapeutic targets may improve patient prognosis. In current study, we demonstrated by real-time PCR that miR-224 expression was significantly upregulated (1.82-fold, P = 0.0025) cervical tissues (n 126) compared with normal 64). Higher associated poorer factors, including advanced FIGO stage, nodal metastasis, larger tumor size, vascular...
Aberrant expression of classical cadherins has been observed in tumor invasion and metastasis, but its involvement cervical carcinogenesis cancer progression is not clear. We investigated E-, P- N-cadherin significance squamous cell carcinoma (SCC) intraepithelial neoplasia (CIN). This retrospective study enrolled 508 patients admitted to Women's Hospital, School Medicine, Zhejiang University with lesions between January 2006 December 2010. Immunochemical staining was performed 98 samples...
Human papillomaviruses (HPV), mainly HPV16 and HPV18, of high-risk classification are involved in cervical cancer carcinogenesis progression. Octamer-binding transcription factor 4 (OCT4) is a key that increased various types. Cervical patients with higher levels OCT4 had worse survival rates. However, the definite mechanisms underlying its function development still remain to be explicated. Here, our study demonstrated expression was slightly tissues than precancerous ones. significantly...
There is currently a lack of research on preoperative prognostic analysis early-stage cervical adenocarcinoma (ADC). The purpose our study was to clarify whether serum tumor-marker levels were value in ADC.We performed retrospective patients with International Federation Gynecology and Obstetrics (FIGO) stage IA1-IIA1 pathology-proven invasive ADC. We evaluated the relationship between clinicopathological characteristics, identified relative risk factors affecting disease-free survival (DFS)...
Mismatch repair-deficient (dMMR) endometrial cancer (EC) is an inflamed phenotype with poor outcomes when meeting high-risk criteria and limited treatment options in the adjuvant setting. We report protocol-prespecified subgroup analysis of patients dMMR tumors from phase III ENGOT-en11/GOG-3053/KEYNOTE-B21 study (ClinicalTrials.gov identifier: NCT04634877 ) newly diagnosed, EC after surgery curative intent. Patients were randomly assigned to pembrolizumab 200 mg or placebo (six cycles) plus...
Preoperative neoadjuvant chemotherapy (NACT) has been widely used in developing countries for the treatment of patients with International Federation Gynecology and Obstetrics (FIGO) stages IB3 IIA2 cervical cancer. However, effectiveness NACT options NACT-insensitive have concerning. This study will assess prognostic differences between primary surgery (PST), determine factors associated prognosis, explore better adjuvant modalities patients.
This study determined interleukin-10 (IL-10) expression in patients with ovarian carcinoma and cell lines, investigated its clinical significance the development progression of carcinoma. Expression IL-10 carcinoma, benign tumour, normal control tissues lines was detected by immunohistochemistry Western blot analysis. concentrations sera ascites from tumour controls, supernatants line cultures were measured enzyme-linked immunosorbent assay. The tissue level significantly higher than...
Background: This study aimed to establish a nomogram by combining clinicopathologic factors with overall survival of stage IA-IIB cervical cancer patients after complete resection pelvic lymphadenectomy. Materials and Methods: was based on retrospective 1,563 who underwent lymphadenectomy from 2002 2008. The constructed multivariate analysis using Cox proportional hazard regression. accuracy discriminative ability the were measured concordance index (C-index) calibration curve. Results:...