A5010798002- Vestibular and auditory disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Global Cancer Incidence and Screening
- Ear Surgery and Otitis Media
- Breast Cancer Treatment Studies
- Hearing Loss and Rehabilitation
- PARP inhibition in cancer therapy
- Ovarian cancer diagnosis and treatment
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Breast Implant and Reconstruction
- BRCA gene mutations in cancer
- AI in cancer detection
- Spinal Fractures and Fixation Techniques
- Ion channel regulation and function
- Economic and Financial Impacts of Cancer
- Health Systems, Economic Evaluations, Quality of Life
- Hearing Impairment and Communication
- Mitochondrial Function and Pathology
- Potassium and Related Disorders
- Gastroesophageal reflux and treatments
- Cancer Mechanisms and Therapy
- Cognitive Science and Mapping
- Cognitive Science and Education Research
- Facial Nerve Paralysis Treatment and Research
Sichuan University
2013-2025
West China Hospital of Sichuan University
2010-2024
Peking University
2024
Peking University Cancer Hospital
2024
The University of Texas MD Anderson Cancer Center
2023
AstraZeneca (Brazil)
2023
University of Toledo
2004
Immunotherapy and chemotherapy combinations have shown activity in endometrial cancer, with greater benefit mismatch repair (MMR)-deficient (dMMR) than MMR-proficient (pMMR) disease. Adding a poly(ADP-ribose) polymerase inhibitor may improve outcomes, especially pMMR
Risk-based breast cancer screening is a cost-effective intervention for controlling in China, but the successful implementation of such requires an accurate prediction model Chinese women.This study aimed to evaluate and compare performance four machine learning algorithms on predicting among women using 10 risk factors.A dataset consisting 7127 cases matched healthy controls was used training testing. We repeated 5-fold cross-validation calculated AUC, sensitivity, specificity, accuracy as...
PURPOSE The OlympiA randomized phase III trial compared 1 year of olaparib (OL) or placebo (PL) as adjuvant therapy in patients with germline BRCA1/2, high-risk human epidermal growth factor receptor 2–negative early breast cancer after completing (neo)adjuvant chemotherapy ([N]ACT), surgery, and radiotherapy. patient-reported outcome primary hypothesis was that OL-treated may experience greater fatigue during treatment. METHODS Data were collected before random assignment, at 6, 12, 18, 24...
PURPOSE Lenvatinib plus pembrolizumab (len + pembro) significantly improved progression-free survival (PFS) and overall (OS) versus chemotherapy in previously treated advanced or recurrent endometrial cancer (aEC) the phase III Study 309/KEYNOTE-775. We report results from III, randomized, open-label European Network of Gynaecological Oncological Trial-en9/LEAP-001 study (ClinicalTrials.gov identifier: NCT03884101 ) that evaluated len pembro first-line aEC. METHODS Patients with stage to IV...
To explore the current research status and trends of potassium-competitive acid blockers (P-CABs) in treatment related diseases (ARDs) using bibliometric analysis. We collected publications to P-CAB acid-related Web Science (WOS) Core Collection from establishment database 30 June 2024. evaluated publication volume citation over years WOS platform, visualized authors, countries, institutions, keywords, citations CiteSpace VOSviewer. This study included a total 455 articles. The number has...
High-quality cancer tissues are essential for future research, especially molecular research. For the sake of better quality tissues, some storage methods chosen according to lab conditions. But impact different storing conditions on RNA, DNA (especially degree methylation), and protein that have undergone a thawing process, is not clear.We analyzed influence including in RNALater solution, normal saline, Opti-mum Cutting Temperature compound (OCT), snap frozen with no protective reagent (as...
To investigate the correlation between KCNE gene family and Meniere's disease (MD) in Chinese population.This study analyzed single-nucleotide polymorphism (SNP) of KCNE1 KCNE3 genes MD group control familial (FMD) sporadic (SMD) group.A total 653 C/T SNPs had a statistical difference FMD SMD groups (p=0.0082<0.05); 492 A/C were statistically different (genotype p=0.037<0.05 allele p=0.006<0.05).SNPs mutations were, respectively, groups. was key to disease, whereas more important onset SMD.
Background: Horizontal canal BPPV (HC-BPPV) has a higher recurrence rate than PC-BPPV. Which maneuver is better for its prognosis still uncertain.Objective: To compare the long-term after Gufoni and Barbecue maneuver.Materials methods: We prospectively collected 61 cases of HC-BPPV which were initially diagnosed in our hospital from first episode, had already ruled out other diseases. Roll them into group alternatively. After maneuver, we followed up until December 2016. Mean follow-up time...
Abstract Background: The primary results from the OlympiA trial were recently reported (NEJM, 2021) after an interim analysis demonstrated statistically significant invasive disease-free survival (DFS) benefit 1 year of olaparib (OL) vs. placebo (PL) 2.5 yrs median follow-up. Although there fewer deaths with OL than PL, overall (OS) did not reach statistical significance threshold prespecified for analysis. initial publication also on adverse event profile, which was similar to that...
Creative computation is a new research field of computational intelligence, and Intuition plays an important role in creativity. The relationship between intuition, experience, association stimuli described quantitative way. experience achieved by Hebb's law. On the basis definition mutation association, process intuition modeled Hopfield neural networks, crossover operators. cognitive models for simulating are established. Finally, example rendering fractal graphs given to show efficiency...
Abstract Background Little is known about how health insurance policies, particularly in developing countries, may influence breast cancer prognosis. We aimed to examine the association between individual plans and cancer-specific mortality among patients China.Methods included 7,436 women diagnosed with invasive January 1 st , 2009, December 31 2016, at West China Hospital, Sichuan University. The plan of each patient was classified as either urban or rural schemes also categorized...
Abstract Background: Both breast-conserving surgery and breast reconstruction are less popular in China, although they can improve patients' quality of life. The main reason comes from the economy. There is currently no economic evaluation different surgical treatment options for early cancer. Our study aims to assess impact long-term cost-effectiveness treatments approaches including mastectomy (MAST), therapy (BCT), with (MAST+RECON). Methods: We applied propensity score matching method...
The rate of genetic deafness in Chengdu is still underestimated.To investigate patients' molecular etiology with profound hearing loss and facilitate counseling for their families, we screened deafness-related genes the population.A total 1427 unrelated patients containing all age groups administrative area City (Sichuan, China) were enrolled this study, average examination 81.13%. Nine loci four deaf-associated (GJB2, GJB3, SLC26A4, mitochondrial 12SrRNA gene) analyzed. Then examined...
To determine the preoperative diagnostic accuracy of MRI and otoneural tests (ONT) for acoustic neuroma (AN) in a cohort unselected patients with pontocerebellar angle tumors. find convenient way to screening out potential asymptomatic AN patient earlier. This study was performed central hospital included consecutive sample unilateral incipient tumor referred ONT before surgery. Different features were collected concluded into variables or variable combinations. Those are analyzed compared...