A5009512405- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Gastric Cancer Management and Outcomes
- Cervical and Thoracic Myelopathy
- MicroRNA in disease regulation
- Diabetes Management and Education
- Esophageal Cancer Research and Treatment
- Estrogen and related hormone effects
- Nutritional Studies and Diet
- Head and Neck Cancer Studies
- Spine and Intervertebral Disc Pathology
- Salivary Gland Tumors Diagnosis and Treatment
- Extracellular vesicles in disease
- MRI in cancer diagnosis
- COVID-19 Clinical Research Studies
- PARP inhibition in cancer therapy
- SARS-CoV-2 and COVID-19 Research
- Medical Imaging and Analysis
- Pancreatic and Hepatic Oncology Research
- Ovarian cancer diagnosis and treatment
- Metal-Organic Frameworks: Synthesis and Applications
- Obstructive Sleep Apnea Research
- Clinical Laboratory Practices and Quality Control
The University of Texas MD Anderson Cancer Center
2023
AstraZeneca (Brazil)
2023
AbbVie (United States)
2023
Tangshan People's Hospital
2023
Yuhuangding Hospital
2022
Binzhou University
2011-2021
Binzhou Medical University
2011-2021
Qiqihar Medical University
2021
State Key Laboratory of Oncogene and Related Genes
2019
Renji Hospital
2003-2019
Since the outbreak of Coronavirus Disease 2019 (COVID-19) in December 2019, various digestive symptoms have been frequently reported patients infected with virus. In this study, we aimed to further investigate prevalence and outcomes COVID-19 symptoms.In descriptive, cross-sectional, multicenter enrolled confirmed who presented 3 hospitals from January 18, 2020, February 28, 2020. All were by real-time polymerase chain reaction analyzed for clinical characteristics, laboratory data,...
Preventive care for adults with diabetes has improved substantially in recent decades. We examined trends the incidence of diabetes-related complications United States from 1990 through 2010.We used data National Health Interview Survey, Hospital Discharge U.S. Renal Data System, and Vital Statistics System to compare incidences lower-extremity amputation, end-stage renal disease, acute myocardial infarction, stroke, death hyperglycemic crisis between 2010, age standardized population year...
Circulating exosome holds great potentials as biomarker for diagnosis and prognosis of human cancers. Previously, we have applied small RNA sequencing to identify aberrantly expressed exosomal miRNAs candidates diagnostic markers in colon cancer patients. In this validation cohort, plasma derived miRNA was isolated from 50 early-stage patients matched healthy volunteers. Real-time qRT-PCR revealed that miR-125a-3p, miR-320c were significantly up-regulated exosomes the with early stage...
Immunotherapy and chemotherapy combinations have shown activity in endometrial cancer, with greater benefit mismatch repair (MMR)-deficient (dMMR) than MMR-proficient (pMMR) disease. Adding a poly(ADP-ribose) polymerase inhibitor may improve outcomes, especially pMMR
Abstract Background: Few options besides the avoidance of smoking and obesity are available to prevent pancreatic cancer. The association between aspirin use risk cancer has been inconsistent across studies. Methods: We performed a population-based study 761 case 794 control subjects frequency matched on sex age during 2006 2011 in Shanghai, China. Participants were asked about episodes regular aspirin, tablets per day or week, ages that started stopped. Data analyzed by unconditional...
OBJECTIVE To examine secular trends in diabetes-related preventable hospitalizations among adults with diabetes the U.S. from 1998 to 2006. RESEARCH DESIGN AND METHODS We used nationally representative data National Inpatient Sample identify hospitalizations. Based on Agency for Healthcare Research and Quality's Prevention Quality Indicators, we considered that associated following four conditions were preventable: uncontrolled diabetes, short-term complications, long-term lower-extremity...
To examine whether there were long-term (between 1988-1994 and 2001-2008) recent 2001-2004 2005-2008) changes in blood pressure (BP) levels among U.S. adults with diagnosed diabetes.
Paclitaxel is one of the commonly used drugs in postoperative chemotherapy for ovarian cancer patients. However, affected by drug dosage and individual differences course medication, patients will have different degrees adverse reactions, which cause damage to patient's body once they occur. This paper retrospectively analyzed clinical data with severe allergic reactions such as fecal incontinence numbness hands feet caused use paclitaxel liposome during a case admitted our hospital. The...
BACKGROUND The sex determing region Y-box 4 (SOX4) gene is a critical developmental transcriptional factor that overexpressed in prostate cancer (PCa). While we and others have investigated the role of SOX4 overexpression PCa, molecular mechanism underlying its aberrant expression remains unclear. METHODS Immunohistochemistry were utilized to detect correlation between estrogen receptor β (ERβ), androgen (AR) cohort 94 clinical specimens. Real-time quantitative PCR Western blotting used...
Abstract Background To compare the Mindray BC‐5180 and Sysmex XN‐1000 instruments by analyzing results of complete blood count in external quality assessment Shandong Province 2018. Methods In assessment, 10 batches control materials were issued throughout year. The test items WBC, RBC, Hb, PLT, HCT. laboratories using screened, analyzed t test, Passing‐Bablok regression analysis, Bland‐Altman analysis. Results Thirty‐six thirty‐six average difference between two is not significant ( P >...
Smoking is one of the most hazardous risk factors for development lung adenocarcinoma (LUAD). Many survival and prognosis-related biomarkers were discovered using database mining. However, precision immune-related long noncoding RNAs (lncRNAs) predictions insufficient. We identified a novel signature to improve estimate smoking-related LUAD prognosis.The Cancer Genome Atlas (TCGA) was used obtain lncRNA expression profiles. The cohort randomly split into discovery validation cohorts. To...
Prognostic markers for colorectal cancer (CRC) have not yet been fully investigated. Phosphatase and tensin homolog (PTEN), p27 Cyclin D1 play significant roles in tumorigenesis cell cycle regulation, therefore require evaluation their prognostic value this disease. The aim of the present study was to assess single combined expression PTEN, CRC patients. Protein levels were examined by immunohistochemistry from 61 patients with either stage Ⅱ or Ⅲ. In tissues, frequencies PTEN(‑), p27(‑)...
At present, it has been noticed that some patients recovered from COVID-19 present a recurrent positive RNA test of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) after being discharged hospitals. The purpose the current study was to characterize clinical features re-hospitalized with results. From January 12 April 1 2020, our retrospective conducted in China. exposure history, baseline data, laboratory findings, therapeutic schedule, and endpoints were collected. All followed...
No epidemiologic studies have directly assessed the association between dietary and urinary isoflavonoids risk of liver cancer in humans.
Abstract Background In recent years, the relationship between malignant tumors and platelets has been paid more attention. The increase of is an independent risk factor for poor prognosis some tumors. Methods This study retrospectively analyzed clinical pathological data 114 patients with initial gastric cancer from August 2005 to 2018 in Shandong Provincial Hospital. Single‐factor multifactor survival analysis were used evaluate effect platelet elevation on postoperative survival. tissues...
Concurrent chemoradiotherapy (CCRT) is the main treatment for esophageal cancer, but response to varies from individual individual. MR imaging methods, such as diffusion-weighted (DW) MRI and use of dynamic contrast-enhanced (DCE) MRI, have potential provide additional biomarkers that could evaluate effect CCRT in patients with carcinoma.Fifty-six carcinoma, verified by histopathology, underwent examination before at midtreatment (4th week, radiotherapy 30-40 Gy) using Siemens 3.0 T System....
Exosomes play crucial roles in intercellular communication and are involved the onset progression of various types cancers, including breast cancer. However, RNA composition cancer-derived exosomes has not been comprehensively explored. We conducted microarray assays on isolated from cancer healthy epithelial cells three patients with hormone receptor (HR) +/ human epidermal growth factor (HER2) - identified 817 differentially expressed genes (DEGs). Among these, 315 upregulated...
Objective: To evaluate the efficacy of psychological interventions for improving immune functioning breast cancer patients.Methods: Comprehensive searches electronic databases from 1990 to 2012, hand reference lists articles, and contacts with researchers.Meta-analytic approaches were used on synthesized findings.Pre-post between-group intervention effects symptoms cortisol, lymphocytes, natural killer cell counts, cytotoxicity assessed, respectively.Results: Data 9 controlled trials...