A5101457631- Diabetes Treatment and Management
- Inflammatory Bowel Disease
- Pain Mechanisms and Treatments
- Species Distribution and Climate Change
- Chronic Kidney Disease and Diabetes
- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Bone Metabolism and Diseases
- Inhalation and Respiratory Drug Delivery
- Gastrointestinal Tumor Research and Treatment
- Lung Cancer Treatments and Mutations
- Blood Pressure and Hypertension Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Appendicitis Diagnosis and Management
- Cancer Treatment and Pharmacology
- Inflammatory Biomarkers in Disease Prognosis
- Diabetes and associated disorders
- Autoimmune and Inflammatory Disorders Research
- Enhanced Recovery After Surgery
- HER2/EGFR in Cancer Research
- Pediatric Pain Management Techniques
- Heat shock proteins research
- Erythropoietin and Anemia Treatment
- Psoriasis: Treatment and Pathogenesis
- Coral and Marine Ecosystems Studies
Peking University People's Hospital
2025
Peking University
2025
Academy of Military Medical Sciences
2024
Wuhan University of Science and Technology
2024
Beijing University of Chinese Medicine
2023
China Medical University
2019-2020
Liaocheng People's Hospital
2020
Zhejiang University
2018-2019
Sir Run Run Shaw Hospital
2018-2019
First Affiliated Hospital of Zhengzhou University
2018
Abstract Studies have found that neutrophil extracellular traps (NETs) which are the specific dying form of upon activation fundamental role in rheumatoid arthritis onset and progression. The purpose this study was to explore therapeutic effect Sinomenine on adjuvant-induced mice, activities regulated by Sinomenine. model established local injection adjuvant treatment administered orally for 30 days, during which, arthritic scores were evaluated joint diameter measured determine disease...
Abstract Thymidylate synthase (TS) is a hot target for tumor chemotherapy, and its inhibitors are an essential direction anti-tumor drug research. To our knowledge, currently, there no reported thymidylate that could inhibit cancer cell migration. Therefore, optimal therapeutic purposes, combines previous reports findings, we hope to obtain multi-effects inhibitor. This study according the principle of flattening designed synthesized 18 N -phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido)phenyl...
Proteomic approaches identifying biomarkers have been applied to asthma only a very limited extent.With an antibody array (RayBiotech, Norcross, GA, USA), the relative intensity and rank differences of 444 proteins were compared in 24 plasma samples obtained at age 3, 11 from children with 12 without diagnoses ages 5 9. Protein candidates identified by quantitated ELISA enlarged sample. Proteins found differentiate also examined for association known Year 1 risk factors, eczema, wheeze.In...
Sinomenine has been reported to effectively repress the progression of lung cancer and breast cancer. However, effects sinomenine in bladder are not well understood. The purpose this study was evaluate cancer.The mRNA expression HEIH cells measured by RT-qPCR. T24 SW780 were treated with for 24 hours. Cell viability detected MTT assay. migration invasion transwell Western blotting assay performed assess protein Bcl-2, Bax, caspase-3.Sinomenine significantly suppressed cell cells. Moreover,...
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Abstract Background: Hepatocellular carcinoma (HCC) is one of the most challenging cancers with high unmet medical need. Glypican-3 (GPC3) an oncofetal glycoprotein anchored to cell surface via GPI (glycosylphosphatidylinositol) and frequently over-expressed in HCC limited expression normal adult tissues, which makes it appealing antibody-drug conjugate (ADC) target for HCC. MRG006A a potentially first-in-class GPC3-targeting ADC composed novel humanized IgG1 antibody conjugated proprietary...
Objective The objective of our study is to validate a plasma proteomic signature, discovered by an antibody array approach, that accompanies asthma risk in early life. Methods A previous identified 4 asthma‐associated proteins (erythropoietin [EPO], galectin‐3, soluble GP130, and eotaxin‐3) 11 samples obtained at age 3 from children with 12 without (assessed 9) birth cohort enrolled nonselectively. We sought EPO assaying for its concentration using R&D Quantikine ELISA the original group...
Objective To explore the therapeutic value of modified endoscopic submucosal dissec- tion with ligation （ESD-L） for small tumors originated from gastric museularis propria. Methods Total 60 patients propria, which was confirmed by ultra- sonography and smaller than 12 mm were recruited to present study. The conventional ESD technique used dissect tumor depth muscularis Then bottom be- neath propria ligated fully a nylon loop. Further dissection applied till whole isolated. Results All...
Objective The objective of our study was to identify plasma proteomic signatures that accompany asthma risk in early life using an antibody array approach. Methods Blood samples from 2 groups three‐year‐old subjects enrolled the Tucson Infant Immune Study were assayed for relative expression 507 proteins by RayBio's Biotin Label‐based Human Antibody Arrays. with no age 9 or wheeze at (no asthma/wheeze; n=6) and (asthma/wheeze; n=11). intensity values signals each plate ranked. Rank...
Objectives To investigate the effects of cell aging on disorders relating to gastric mucosa aging. Methods A treatment 200 μmol/L H2O2 was used induce senescence human epithelial line GES-1, and growth curve monitored.Senescence secretory phenotypes were observed by detecting protein level p53 p16INK4a with senescence-associated β-galactosidase(SA-β-gal)staining Western blot testing.The mRNA levels phenotype(SASP)factors in GES-1 including IL-1β, IL-6, IL-8, TGF-β、IFN-γ, VEGF-A...