A5010347083- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Intraperitoneal and Appendiceal Malignancies
- Multiple and Secondary Primary Cancers
- Cancer Risks and Factors
- PARP inhibition in cancer therapy
- Cervical Cancer and HPV Research
- BRCA gene mutations in cancer
- Colorectal and Anal Carcinomas
- Global Cancer Incidence and Screening
- Angiogenesis and VEGF in Cancer
- Economic and Financial Impacts of Cancer
- Chronic Lymphocytic Leukemia Research
- Family Support in Illness
- Kruppel-like factors research
- Metastasis and carcinoma case studies
- DNA Repair Mechanisms
- Neuroendocrine Tumor Research Advances
- Plant Pathogens and Resistance
- Ureteral procedures and complications
- Intestinal and Peritoneal Adhesions
- Endometriosis Research and Treatment
- Pregnancy and Medication Impact
- Assisted Reproductive Technology and Twin Pregnancy
- PI3K/AKT/mTOR signaling in cancer
Gdańsk Medical University
2015-2025
Immunotherapy and chemotherapy combinations have shown activity in endometrial cancer, with greater benefit mismatch repair (MMR)-deficient (dMMR) than MMR-proficient (pMMR) disease. Adding a poly(ADP-ribose) polymerase inhibitor may improve outcomes, especially pMMR
Background: Recent publications underscore the need for updated recommendations addressing less radical surgery <2 cm tumors, induction chemotherapy, or immunotherapy locally advanced stages of cervical cancer, as well systemic therapy recurrent metastatic cancer. Aim: To summarize current evidence diagnosis, treatment, and follow-up cancer provide evidence-based clinical practice recommendations. Methods: Developed according to AGREE II standards, guidelines classify scientific based on...
To develop a multifactorial model that allows the prediction of bronchopulmonary dysplasia (BPD) in preterm newborns.A single-center retrospective study infants born below 32 + 0 weeks gestational age. We created receiver operating characteristic curve to assess BPD risk and calculate accuracy using area under (AUC). was categorized predictive based on weight evidence.Of 278 analyzed newborns, 127 (46%) developed BPD. The significant factors for multivariate analysis were age, number red...
The aim of this study was to selectively profile the activation status mammalian target rapamycin (mTOR)-associated oncogenes and tumor suppressor genes (TSGs) in ovarian cancer specimens, healthy ovaries benign tumors, including endometrial cysts. We used a novel type microfluidic gene array examine expression 15 human suppressors specimens 53 patients, cysts 29 women (endometrial simple) 11 individuals whom material obtained during total hysterectomies performed because fibroid changes....
<h3>Introduction/Background</h3> Effective and well-tolerated treatments for PROC remain an unmet medical need; standard of care single agent chemotherapy has limited efficacy, with response rates at ~12%. Upifitamab rilsodotin (UpRi) is a Dolaflexin, high Drug-to-Antibody Ratio ADC targeting NaPi2b, sodium-dependent phosphate transporter broadly expressed in high-grade serous epithelial ovarian cancer, expression normal tissues. UPLIFT was single-arm Ph2 trial evaluating the efficacy safety...
Introduction. Cervical cancer is the 4th most common in terms of incidence and mortality women worldwide. The aim study was to investigate analyze effects Poland's publicly funded cervical screening treatment programs. Material methods. analyzed financial epidemiological data provided by Polish National Health Fund Cancer Registry on prevention Poland 2011–2017. Results. Our identified a systematic reduction number patients undergoing cytology. Despite high levels expenditure, no correlation...
To report the results of ovarian cancer treatment, where a regimen intravenous cyclophosphamide followed by intraperitoneal cisplatin or carboplatin was administered as second line treatment.Retrospective observational study on 198 women with stage I-IV histologically documented epithelial after one more prior regimens chemotherapy.University tertiary referral clinic, Gdansk, Poland.The group recruited from among 593 patients treated between January 1996 and December 2006. Conditions...
Pregnancy-related anxiety (PrA) is a specific type of characteristic the perinatal period. PrA can affect pregnancy and birth. However, no validated tool exists to measure in Polish obstetric practice. The aim this study was translate Pregnancy-Related Anxiety Questionnaire-Revised 2 (PRAQ-R2) into evaluate its reliability factorial construct validity. This conducted Poland as an online questionnaire April 2020 included 175 healthy women. To validate PRAQ-R2, we used standardized tools for...
Current oncological developments are based on improved understanding of genetics, and especially the discovery genes whose alterations affect cell functions with consequences for whole body. Our work is focused most important these genes, BARD1 its oncogenic role in breast cancer. Most importantly, study points to new avenues treatment prevention frequent female cancer research. The BRCA1 proteins have similar structures functions, they combine form molecule BARD1-BRCA1 heterodimer. Through...
Current oncological developments are based on improved understanding of genetics, and especially the discovery genes whose alterations affect cell functions with consequences for whole body. Our work is focused one these genes, BARD1 its oncogenic role in breast cancer. Most importantly, study points to new avenues treatment prevention most frequent female cancer research. The BRCA1 proteins have similar structures functions, they combine form molecule BARD1-BRCA1 heterodimer. complex...