A5049001219- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Electrochemical sensors and biosensors
- Nanoparticle-Based Drug Delivery
- Drug-Induced Hepatotoxicity and Protection
- Liver Diseases and Immunity
- RNA Interference and Gene Delivery
- Conducting polymers and applications
- Advancements in Transdermal Drug Delivery
- Lipid Membrane Structure and Behavior
- Supramolecular Self-Assembly in Materials
- Colorectal and Anal Carcinomas
- Contact Dermatitis and Allergies
- Endometrial and Cervical Cancer Treatments
- Cancer-related Molecular Pathways
- Advanced Drug Delivery Systems
- Nanoplatforms for cancer theranostics
- Pharmacogenetics and Drug Metabolism
- Trace Elements in Health
- Eicosanoids and Hypertension Pharmacology
- Bioactive Natural Diterpenoids Research
- MicroRNA in disease regulation
- Cancer Mechanisms and Therapy
- Heavy Metal Exposure and Toxicity
- Genetic factors in colorectal cancer
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2025
The University of Texas MD Anderson Cancer Center
2023
AstraZeneca (Brazil)
2023
Institute of Medicinal Plant Development
2021
Peking University
2020
King University
2020
Nanchang University
2019
Obstetrics and Gynecology Hospital of Fudan University
2017
Huazhong University of Science and Technology
2009
Tongji Hospital
2009
Immunotherapy and chemotherapy combinations have shown activity in endometrial cancer, with greater benefit mismatch repair (MMR)-deficient (dMMR) than MMR-proficient (pMMR) disease. Adding a poly(ADP-ribose) polymerase inhibitor may improve outcomes, especially pMMR
The cytochrome P450 epoxygenase, CYP2J2, converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EETs). We found recently that this enzyme is dramatically up-regulated in a variety of established human carcinoma cell lines and cancerous tissue promotes the neoplastic phenotype. In present study, we tested hypothesis specific inhibitors CYP2J2 related drug terfenadine are effective antitumor agents. Four these (compounds 4, 5, 11, 26) were for effectiveness vitro vivo....
Liver fibrosis is a major contributor to the morbidity and mortality associated with liver diseases, yet effective treatment options remain limited. Hepatic stellate cells (HSCs) are promising target for hepatic fibrogenesis due their pivotal role in disease progression. Our previous research has demonstrated potential of Dihydrotanshinone I (DHI), lipophilic component derived from natural herb Salvia miltiorrhiza Bunge, treating by inhibiting YAP/TEAD2 interaction HSCs. However, clinical...
Objective To comparatively evaluate the hematological toxicity (HT) associated with 3 concurrent chemoradiotherapies that are routinely used to treat cervical cancer, including 3-dimensional conformal radiotherapy (3DCRT), intensity-modulated radiation therapy (IMRT), and RapidARC establish a new normal tissue complication probability model of bone marrow (BM) predict HT in cancer patients undergoing chemoradiotherapy. Methods Patients (N = 100) who received cisplatin whole-pelvic were...
The goal is to develop an in situ gel system comprising anionic liposomes (AL) containing bleomycin A6 (BLM A6) dispersed within the thermosensitive for sustained release. results indicated that gelation temperature decreased due AL gel. Similarly, viscosity and mechanical parameters, such as strength gel, could be enhanced by inducing lipid material with negative charge (phosphatidylglycerol) at 37 °C, which provided against corrosion physiological condition. vitro release experiments...
The main objective of the present work was to prepare and assess dermal delivery tacrolimus-loaded ethosomes versus classic liposomes. Both systems were characterized for particle size, polydispersity index, entrapment efficiency (EE), by dynamic laser diffraction ultrafiltration or dialysis methods, respectively. results indicated that presence ethanol in formulations affected size. In addition, method selected determine EE due relatively short period as compared with method. Ethosomes...
Liver fibrosis, a complex process resulting from most chronic liver diseases, remains devoid of effective treatments. An increasing body evidence links fibrosis to the "gut-liver axis", with disruptions in gut microbiota-host balance emerging as critical contributor its progression. Cinnamaldehyde (Cin), natural compound antioxidant, anti-inflammatory, and anticytotoxic properties, has shown potential counteracting hepatic stellate cell (HSC) activation. Additionally, Cin been promote...
5518 Background: Concurrent chemoradiotherapy (CCRT) followed by intrauterine brachytherapy is the standard treatment for LACC, while therapeutic efficacy can be limited an immunosuppressive tumor microenvironment (TME). PD-1 inhibition has displayed and a clinically manageable safety profile in patients with cervical cancer. Single-cell RNA sequencing (scRNA-seq) of paired pre-treatment on samples offers dynamic detailed examination transcriptomic changes TME under different conditions....
Tumor metastasis has become a key obstacle to cancer treatment, which causes high mortality. Nowadays, it involves multiple complex pathways, and conventional treatments are not effective due fewer targets. The aims of the present study were construct novel liposome delivery system co-loading specific PLD inhibitor 5-fluoro-2-indolyldes-chlorohalopemide (FIPI) in combination with antitumor drug doxorubicin (DOX) functional excipient D-alpha tocopheryl acid succinate (α-TOS) for...
Dimercaptosuccinic acid (DMSA) is an oral heavy metal chelator. Although DMSA the most acceptable chelator in urinary excretion of toxic elements from children and adults, its defects plasma binding membrane permeability limit interaction with intracellular affect efficacy chelation therapy. Herein, a novel nanocomposite composed mesoporous silica nanoparticles (MSNs), disulfide bond, was synthesized characterized scanning/transmission electron microscope, IR Raman spectra, TGA analysis. The...
Background: Liver fibrosis, as a common and refractory disease, is challenging to treat due the lack of effective agents worldwide. Recently, we have developed novel compound, N-(3,4,5-trichlorophenyl)-2(3-nitrobenzenesulfonamide) benzamide (IMB16-4), which expected good potential effects against liver fibrosis. However, IMB16-4 water-insoluble has very low bioavailability. Methods: Mesoporous silica nanoparticles (MSNs) were selected drug carriers for purpose increasing dissolution IMB16-4,...
Liver fibrosis remains a significant public health problem. However, few drugs have yet been validated. Costunolide (COS), as monomeric component of the traditional Chinese medicinal herb Saussurea Lappa, has shown excellent anti-fibrotic efficacy. COS displays very poor aqueous solubility and stability in gastric juice, which greatly limits its application via an oral administration. To increase stability, improve dissolution rate enhance anti-liver COS, pH-responsive mesoporous silica...
Herbal medicines have been recognized as an attractive approach for cancer therapy with minimal side effects. The present study investigated the type of interaction between a novel lipid-soluble extract from Pinellia pedatisecta Schott (PE) and cisplatin (CDDP) on human cervical SiHa CaSki cell lines in vitro. mechanism this combination was studied using proliferation, invasion apoptosis assays, by analyzing cycle distribution protein expression, focus DNA damage response (DDR) activation....
Herbal medicines are known to have numerous benefits, including lower toxicity and fewer side effects than traditional chemotherapeutic drugs. In Chinese medicine, the rhizome of Pinellia pedatisecta (PE) Schott has long been used treat cancer, undiagnosed swelling erythema toxicum. However, its medical benefits lack support from scientific evidence. A novel lipid-soluble extract PE previously verified enhance cytotoxicity cis-dichlorodiammineplatinum-II (CDDP) against human cervical cancer...
Liver fibrosis is challenging to treat because of the lack effective agents worldwide. Recently, we have developed a novel compound, N-(3,4,5-trichlorophenyl)-2(3-nitrobenzenesulfonamido) benzamide referred as IMB16-4. However, its poor aqueous solubility and oral bioavailability obstruct drug discovery programs. To increase dissolution, improve enhance antifibrotic activity IMB16-4, PVPK30 was selected establish IMB16-4 nanoparticles. Drug release behavior, bioavailability, anti-hepatic...
As a global health problem, liver fibrosis still does not have approved treatment. It was proved that N-(3,4,5-trichlorophenyl)-2(3-nitrobenzenesulfonamide) benzamide (IMB16-4) has anti-hepatic activity. However, IMB16-4 displays poor water solubility and bioavailability. We are devoted to developing biodegraded liposome-coated polymeric nanoparticles (LNPs) as delivery systems for improving aqueous solubility, cellular uptake, anti-fibrotic effects. The physical states of IMB16-4-LNPs were...
Abstract Parkinson's disease (PD), one of the most common movement and neurodegenerative disorders, is challenging to treat. Levodopa a clinical drug for controlling symptoms PD, but it only replenishes missing dopamine, can’t protect dopaminergic neurons. While curcumin as neuroprotective agent has been reported treatment PD. Herein, we present novel organic-inorganic composite nanoparticle with brain targeting (lf-protocells) co-delivery levodopa curcumin, demonstrate its attractive use...
Abstract Parkinson's disease (PD), one of the most common movement and neurodegenerative disorders, is challenging to treat, partly because blood-brain barrier blocks passage drugs. Levodopa a clinical drug for controlling symptoms PD, but it only replenishes missing dopamine, can’t protect dopaminergic neurons. While curcumin as neuroprotective agent has been reported treatment PD. Herein, we present novel organic-inorganic composite nanoparticle with brain targeting (denoted lf-protocells)...
Abstract Parkinson's disease (PD), one of the most common movement and neurodegenerative disorders, is challenging to treat, partly because blood-brain barrier blocks passage drugs. Levodopa a clinical drug for controlling symptoms PD, but it only replenishes missing dopamine, can’t protect dopaminergic neurons. While curcumin as neuroprotective agent has been reported treatment PD. Herein, we present novel organic-inorganic composite nanoparticle with brain targeting (denoted lf-protocells)...