Air pollution is currently one of the greatest threats to global health. Polish cities are among most heavily polluted in Europe. Due air 43,100 people die prematurely Poland every year. However, these data do not take into account health consequences for unborn children. Thus, aim this study was evaluate effects fine particulate matter (less than 2.5 μm diameter) on pregnancy outcomes. An analysis pregnant women and their children made using a questionnaire survey from nationwide conducted...

The goal of this retrospective analysis was to compare the results treatment in patients with early cervical cancer managed by laparoscopy those for observed after laparotomy.The carried out 22 operated on total laparoscopic hysterectomy and 58 treated abdominal hysterectomy. Patients clinical tumor stage IA, IB1, or IIA were eligible surgery. main efficacy end point disease-free survival evaluated Kaplan-Meier method. curves compared using log-rank tests. In addition, length...

Genes encoding hormone receptors are among candidate genes modulating the risk of ovarian cancer. We aimed to assess a frequency PGRG+331A, FSHRAla307Thr, and FSHRSer680Asn polymorphic variants, length (CAG)n (GGN)n repeat tracts in androgen receptor gene (AR) with respect cancer outcome. genotyped 215 patients 352 unaffected control subjects. Statistical analysis was performed logistic regression model adjustment for age. Clinical importance variants evaluated multivariate models on 69...

Abstract Aim Endometrial biopsy is one of the most commonly performed gynecological procedures. Apart from patient safety, important to obtain an adequate specimen allowing histopathological diagnosis. The aim study was determine rate endometrial sampling failure and factors affecting quality obtained for examination among patients who underwent Pipelle dilatation curettage (D&C). Methods Patients (Pipelle, D&C) at 1st Department Obstetrics Gynecology, Medical University Warsaw,...

Abstract Background In clinical practice alterations in CA-125 concentration within normal range patients with ovarian cancer after first-line treatment are common. Even minor increase is associated patients’ anxiety and difficult interpretation counselling for clinicians. The aim of this study was to evaluate the significance fluctuations reference level who suffered from complete response treatment. Results 168 epithelial cancer, achieved remission first line were enrolled study....

With the growing development of 5G and its new services, edge computing is becoming cornerstone ongoing network transformation. Its integration into infrastructure brings research opportunities related to design implementation high-performance systems, enabling accomplishment three main promises 5G: very high speed, low latency, massive connectivity. This trend has generated strong interest in realizing effective life cycle management latency-sensitive applications order achieve a level QoS...

The aim of the study was to assess concordance between preoperative endometrial sampling and microscopic examination hysterectomy specimens in patients surgically treated for atypical hyperplasia carcinoma.We analysed a group 204 patients, whom 160 (78.43%) underwent surgical treatment cancer corpus uteri 44 (21.57%) hyperplasia. diagnosis based on histological endocervical samples obtained by fractional curettage it compared findings at hysterectomy. comparison made basic diagnosis, type...

Changes that took place in Europe the early 1990s had an impact on health-associated issues. They were impulse for changes healthcare systems and, consequently, also cancer control programmes. Those effect mortality rates due to cervical (CC). Therefore, aim of this study is analyse CC trends east-central after 1990. Data deaths retrieved from WHO Mortality Database. Trends European countries between 1990 and 2017 assessed using Joinpoint Regression Program software. decreased majority...

Abstract Purpose To establish the distribution of diandric and digynic triploidy depending on gestational age. Methods 107 triploid samples tested prospectively in a single genetic department during four-year period were analyzed for parental origin by Quantitative Fluorescent Polymerase Chain Reaction (QF-PCR) ( n =95) with use matching or MS-MLPA =12), when unavailable. Tested pregnancies divided into three subgroups regard to age at spontaneous pregnancy loss: <11 weeks, 11–14 >14...

The objective of the current study was to compare results surgical treatment in endometrial cancer with use laparoscopy and traditional approach laparotomy. Our goal evaluate morbidity, recurrence rate, disease-free survival both groups. This article is a retrospective study. A chart review 45 patients treated by between 1994 2002 136 laparotomy 2001 performed. Disease-free groups evaluated Kaplan-Meier method compared using log-rank test. rate recidive 6% group 13% group. There no...

Objectives: The aim of this study is to assess the effectiveness pipelle in sampling diagnostic material from uterine cavity and determining clinical factors, which may affect its effectiveness. Material methods: retrospective analysis included 312 patients who underwent biopsy because various indications. Evaluated factors method were: types indications for procedure, age, BMI, anteflexion or retroflexion uterus, presence fibroids, miscarriages, natural deliveries, deliveries general....

Molecular alterations in tumor-adjacent tissues have recently been recognized some types of cancer. This phenomenon has not studied endometrial We aimed to analyze the expression genes associated with cancer progression and metabolism primary samples matched endometria from cancer-free patients uterine leiomyomas. Paired tumors 49 (EC), endometrium 25 leiomyomas uterus, 4 cell lines were examined by RT-qPCR, for MYC, NR5A2, CXCR2, HMGA2, LIN28A, OCT4A, OCT4B, OCT4B1, TWIST1, STK11, SNAI1,...

The objective of this study was to evaluate the nadir CA-125 in patients with epithelial ovarian cancer. A total 168 who achieved complete remission (no clinical and radiological signs, ≤ 35 U/ml) after first-line treatment were enrolled study. relationship between survival examined by applying generalized additive models Cox proportional hazards model. median concentration 10 U/ml (2.7-35 U/ml). related progression-free but not overall survival. risk recurrence 11-25 26-35 compared 1.87 (p...

Background and Objectives: Cervical cancer (CC) is the fourth most common cause of cancer-related morbidity mortality among women worldwide. CC prevention based on screening HPV vaccination. The COVID-19 pandemic has caused difficulties in implementing CC-preventative measures. aim this study was to collect data implementation prophylaxis Poland provided by public private health care with a particular focus impact attempt estimate level CC-screening 2026 under care. Materials Methods: Data...

The surgical treatment of advanced ovarian cancer is based on the maximal debulking with widening operation range to infiltrated organs. aims are as follows: (1) assessment quantity and quality intra- postoperative complications in patients which partial bowel resection was performed (2) evaluation related surgery anastomosis, compared Hartmann's procedure. analysis procedures intestinal period 39 patients, FIGO stage III–IV, performed. During operations, most frequent type sigmoidectomy or...

The purpose of this study was to evaluate the results chemotherapy pulmonary metastases from invasive carcinoma cervix, which were detected after a disease-free period initial treatment with surgery or radiotherapy. Fifty patients radiologically proven treated chemotherapy. All received platinum-5-fluorouracil (PF) program: cisplatin 75 mg/m(2) and 5-fluorouracil 800 every 4 weeks. overall 1- 3-year survival PF 62% 17.6%, respectively. progression-free at 1 3 years 36.7% 14.3%, There 6 (12%)...

Assessment of the regional lymph node status is an integral part diagnostics for ovarian cancer patients. Due to risk complications, lymphadenectomy patients, as a routine treatment procedure, still subject controversy. Therefore, present study aimed evaluate frequency and nature intraoperative postoperative complications in patients treated with surgery. In addition, comparison surgical between who underwent those did not was carried out. A retrospective analysis 211 consecutive surgery...