A5100367870- Drug Transport and Resistance Mechanisms
- PI3K/AKT/mTOR signaling in cancer
- Lung Cancer Treatments and Mutations
- Sphingolipid Metabolism and Signaling
- Cancer therapeutics and mechanisms
- Chaos control and synchronization
- Computational Drug Discovery Methods
- Ovarian cancer diagnosis and treatment
- PARP inhibition in cancer therapy
- Biochemical and Molecular Research
- Graphene and Nanomaterials Applications
- Neuroendocrine Tumor Research Advances
- Genetic factors in colorectal cancer
- Medicinal Plant Pharmacodynamics Research
- Wound Healing and Treatments
- Traditional Chinese Medicine Analysis
- Pancreatic and Hepatic Oncology Research
- Cytomegalovirus and herpesvirus research
- Chemistry and Chemical Engineering
- Click Chemistry and Applications
- Cancer Immunotherapy and Biomarkers
- Chemical Synthesis and Reactions
- Preterm Birth and Chorioamnionitis
- Telomeres, Telomerase, and Senescence
- Protein Degradation and Inhibitors
Marine Biomedical Research Institute of Qingdao
2022-2025
Guangdong Provincial People's Hospital
2023-2025
Jinan University
2025
Ocean University of China
2021-2024
Chinese Academy of Medical Sciences Dermatology Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Xihua University
2024
AstraZeneca (United States)
2023-2024
Qingdao National Laboratory for Marine Science and Technology
2021-2023
South China Agricultural University
2022
Immunotherapy and chemotherapy combinations have shown activity in endometrial cancer, with greater benefit mismatch repair (MMR)-deficient (dMMR) than MMR-proficient (pMMR) disease. Adding a poly(ADP-ribose) polymerase inhibitor may improve outcomes, especially pMMR
Designing selective PARP-1 inhibitors has become a new strategy for anticancer drug development. By sequence comparison of and PARP-2, we identified possible site (S site) consisting several different amino acid residues α-5 helix D-loop. Targeting this S site, 140 compounds were designed, synthesized, characterized their activities mechanisms. Compound
Background: A paramount issue in the realm of chronic wound healing among diabetic patients is pervasive inflammatory response that persistently thwarts angiogenesis, thereby precipitating protracted delays process such wounds. Employing zeolitic imidazolate framework-8 (ZIF-8) as a drug delivery platform, integrated within temperature-sensitive injectable hydrogel, presents an intriguing strategy for closure various irregular wounds, modulation responses, and promotion angiogenesis....
Wound healing has been a great challenge throughout human history. Improper treatment for wounds is so easy to lead infection and series of serious symptoms, even death. Because the ability absorbing fluid keeping moist environment, hydrogel with 3D networks ideal candidate wound dressing. More important, it good biocompatibility. However, most dressings reported have weak mechanical properties adhesion properties, which greatly limit their clinical application. Herein, tough adhesive...
An E / Z isomer strategy was designed to precisely regulate the type of ROS and enable tumor imaging PDT.
<h3>Introduction/Background</h3> Combination of immunotherapy with carboplatin/paclitaxel (CP) has demonstrated improved progression-free survival (PFS) and overall (OS) in patients advanced endometrial cancer. The Phase III DUO-E/GOG-3041/ENGOT-EN10 trial (NCT04269200) evaluated the addition durvalumab to standard first-line CP, followed by ± olaparib, <h3>Methodology</h3> Patients newly diagnosed Federation Gynecology Obstetrics Stage III/IV or recurrent cancer naïve systemic treatment...
Mucositis may limit the therapeutic window for mammalian target of rapamycin inhibitor-based combination therapy, necessitating treatment interruptions and/or dose reductions. Optimizing or prophylactic interventions mucositis will enable patients to continue effective while maintaining good quality life.
The Papain-Like proteases (PLpro) of SARS-CoV-2 play a crucial role in viral replication and the formation nonstructural proteins. To find available inhibitors, 3D structure PLpro SARS2 was obtained by homologous modelling, we used this as target to search for inhibitors through molecular docking MM/GBSA binding free energy rescoring. A novel hydrogen bonding penalty applied screening process, which meanwhile took desolvation into account. Finally, 61 compounds were acquired 4 them with IC50...
Resistance to 5-FU reduces its clinical efficacy for the treatment of colorectal cancer. Sphingosine-1-phosphate receptor 2 (S1PR2) has emerged as a potential target reverse 5-FU-resistance by inhibiting expression dihydropyrimidine dehydrogenase (DPD). In this study, 38 novel S1PR2 antagonists based on aryl urea structure were designed and synthesized, structure–activity relationship was investigated binding assay. Representative compound 43 potently interacts with KD value 0.73 nM. It...
The aim of this study is to improve the quality testing for glucose-6-phosphate dehydrogenase (G6PD) deficiency through evaluation and analysis laboratory tests G6PD activity. External assessment (EQA) was carried out twice per year with five samples each from 2014 2016. Samples were used quantitative qualitative assays. Quantitative results collected, determined reference values, information about methods, reagents instruments participating laboratories within required time. Laboratory...
Abstract Background: Senescent human skin primary fibroblast (FB) models have been established for studying aging-related, proliferative, and inflammatory diseases. The aim of this study was to compare the transcriptome characteristics dermal FBs from children elderly with four senescence models. Methods: Human were obtained healthy (FB-C) donors (FB-E). Senescence generated by ultraviolet B irradiation (FB-UVB), D-galactose stimulation (FB-D-gal), atazanavir treatment (FB-ATV), replication...