A5072541500- Click Chemistry and Applications
- Marine Sponges and Natural Products
- Quinazolinone synthesis and applications
- Synthesis and biological activity
- Synthesis of Indole Derivatives
- Photochromic and Fluorescence Chemistry
- interferon and immune responses
- Catalytic C–H Functionalization Methods
- Synthesis and Biological Activity
- Cancer therapeutics and mechanisms
- Synthesis and Characterization of Heterocyclic Compounds
- Peroxisome Proliferator-Activated Receptors
- Caveolin-1 and cellular processes
- Receptor Mechanisms and Signaling
- Autophagy in Disease and Therapy
- Coral and Marine Ecosystems Studies
- Bioactive Compounds and Antitumor Agents
- Adenosine and Purinergic Signaling
- Phosphodiesterase function and regulation
- Kruppel-like factors research
- Cholinesterase and Neurodegenerative Diseases
- Sirtuins and Resveratrol in Medicine
- HER2/EGFR in Cancer Research
- Mechanisms of cancer metastasis
- Traditional and Medicinal Uses of Annonaceae
Ocean University of China
2022-2025
Qingdao National Laboratory for Marine Science and Technology
2022-2025
The transferrin receptor 1 (TfR1) plays a key role in cellular iron uptake through its interaction with iron-bound Tf. TfR1 is often reported to be overexpressed malignant cells, and this increase may associated poor prognosis different types of cancer, which makes it an attractive target for antitumor therapy. marine natural product Muriceidine A potent anticancer agent our previous work. In study, we designed synthesized series derivatives described the systematic investigation into their...
Comprehensive Summary Thirteen new nitrogen‐containing nardosinane‐type sesquiterpenoids, clavukoelloids A—M ( 1 — 13 ) with unique acrylamide fragments vs. the reported general sesquiterpenoids containing lactone, were isolated from soft coral Clavularia koellikeri collected South China Sea. The structures and absolute configurations of compounds unambiguously determined by analysis spectroscopic data, CP3, DP4+, ECD spectra, X‐ray diffraction. Compound 6 showed anti‐inflammatory activities...
To develop new highly effective anticancer agents derived from naturally occurring stilbene scaffold, in total of 24 indole and indazole-based stilbenes including 17 compounds were designed according to molecular hybridization strategy synthesized via Witting reaction. The cytotoxic screening results against human tumor cell lines (K562 cells MDA-MB-231 cells) showed that are great interest for developing as eight derivatives possessed strong antiproliferative activities with IC50 values...
Fourteen new verticillane diterpenoids, heterolactone (1) and heterolactams A–M (2–14), were isolated from the soft coral Heteroxenia ghardaqensis. They structurally share same 6/12 bicyclic carbon skeleton that is not commonly encountered in marine organisms. The structures, including absolute configurations, determined by extensive spectroscopic analysis, single-crystal X-ray diffraction calculated ECD spectra, DP4+ probability analyses. Compounds 5, 8, 9 showed anti-inflammatory...
Guaiazulene and related derivatives were famous for diverse biological activities. In an effort to discover new highly efficient candidate drugs derived from guaiazulene, four series of guaiazulene designed, synthesized, evaluated antiproliferation, antiviral, anti-inflammatory peroxisome proliferators-activated receptor γ (PPARγ) signalling pathway agonist Among them, two condensation showed selective cytotoxic activities towards K562 cell with IC50 values 5.21 μM 5.14 μM, respectively,...
Phosphodiesterases (PDEs), a superfamily of enzymes that hydrolyze cyclic adenosine monophosphate (cAMP) and guanosine (cGMP), are recognized as therapeutic target for various diseases. However, the current screening methods PDE inhibitors usually experience problems due to complex operations and/or high costs, which not conducive drug development in respect this target. In study, new method based on GloSensor technology was successfully established applied, resulting discovery several novel...
In the present study, three series of 35 pyridine-based stilbenes include 10 new compounds prepared by Horner-Wadsworth-Emmons (HWE) reaction were assayed for cytotoxic activities toward two tumoral cell lines (K562 and MDA-MB-231) one non-tumoral line (L-02). The bioassay results indicated that hybrid formed at C-3 position pyridine displayed stronger antiproliferative against K562 cells C-4 showed broad-spectrum effects. Among them, stilbene