A5101602702- RNA modifications and cancer
- Ovarian cancer diagnosis and treatment
- Cancer Immunotherapy and Biomarkers
- Endometrial and Cervical Cancer Treatments
- Immune Cell Function and Interaction
- RNA and protein synthesis mechanisms
- CAR-T cell therapy research
- RNA Research and Splicing
- Immunotherapy and Immune Responses
- Lymphoma Diagnosis and Treatment
- Kruppel-like factors research
- Metabolism, Diabetes, and Cancer
- T-cell and B-cell Immunology
- Synthetic Organic Chemistry Methods
- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- Heat shock proteins research
- Technology and Human Factors in Education and Health
- Metabolomics and Mass Spectrometry Studies
- Colorectal and Anal Carcinomas
- Recommender Systems and Techniques
- Reproductive Biology and Fertility
- Delphi Technique in Research
- Gastric Cancer Management and Outcomes
- Biochemical and Molecular Research
Peking University Third Hospital
2021-2024
Peking University
2021-2024
Helmholtz Zentrum München
2024
Technical University of Munich
2024
Peking Union Medical College Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Academy of Medical Sciences
2024
Affiliated Hospital of Guizhou Medical University
2024
Guiyang Medical University
2024
Guangzhou Medical University
2024
Hepatitis B virus (HBV)-DNA integration in HBV-related hepatocellular carcinoma (HBV-HCC) can be targeted by HBV-specific T cells. SCG101 is an autologous, T-cell product expressing a receptor (TCR) after lentiviral transduction recognizing the envelope-derived peptide (S20-28) on HLA-A2. We here validated its safety and efficacy preclinically applied it to HCC patient (NCT05339321). Good Manufacturing Practice-grade manufactured cells were assessed for off-target reactivity functionality...
Two novel nitrogenous diterpenoids, sarinfacetamides A (1) and B (2), featuring an uncommon tricyclo[6.3.1.01,5]dodecane scaffold, a known related diterpene (3) were isolated from the South China Sea soft coral Sarcophyton infundibuliforme. Their structures, including absolute configuration of 1, established by extensive spectroscopic analysis TDDFT-ECD calculation. Compounds 1 3 exhibited interesting promotion effects on ConA-induced T lymphocyte proliferation. plausible biosynthetic...
Metformin, a drug prescribed to treat type 2 diabetes, has been reported possess antitumor activity via immunity activation. However, the influence of metformin on natural killer (NK) cells is not fully understood. Here, we investigated whether exerts potent anticancer effect by activating NK cells. The results showed that sustained exposure enhances cytolytic NK-92 Moreover, this enhancement cytotoxicity was also observed in from healthy peripheral blood and cancer patient ascites....
Abstract Background Eukaryotic elongation factor-2 kinase (eEF2K) is a Ca 2+ /calmodulin (CaM)-dependent protein that inhibits synthesis. However, the role of eEF2K in cancer development was reported paradoxically and remains to be elucidated. Methods Herein, A549 cells with depletion or overexpression by stably transfected lentivirus plasmids were used vitro vivo study. MTT colony assays detect cell proliferation growth. Extracellular glucose lactate concentration measured using test kit....
<h2>Summary</h2> Ovarian cancer (OC) causes high mortality in women because of ineffective biomarkers for early diagnosis. Here, we perform metabolomics analysis on an initial training set uterine fluid from 96 gynecological patients. A seven-metabolite-marker panel consisting vanillylmandelic acid, norepinephrine, phenylalanine, beta-alanine, tyrosine, 12-S-hydroxy-5,8,10-heptadecatrienoic and crithmumdiol is established detecting early-stage OC. The further validated independent sample 123...
Emerging advances in cancer therapy have transformed the landscape towards immunotherapy regimens. Recent discoveries resulted development of clinical immune checkpoint inhibitors that are 'game-changers' for immunotherapy. Here we show eEF2K, an atypical protein kinase negatively modulates elongation stage synthesis, promotes synthesis PD-L1, which helps cells to escape from immunosurveillance. Ablation eEF2K prostate and lung markedly reduced expression levels PD-L1 protein. We association...
Objective: Glycogen synthase kinase-3β (GSK3β) has been recognized as a suppressor of Wnt/β-catenin signaling, which is critical for the stemness maintenance breast cancer stem cells. However, regulatory mechanisms GSK3β protein expression remain elusive. Methods: Co-immunoprecipitation and mass spectral assays were performed to identify molecules binding GSK3β, characterize interactions heat shock 90 (Hsp90), co-chaperones. The role PGK1 in Hsp90 chaperoning was evaluated by constructing...
The transferrin receptor 1 (TfR1) plays a key role in cellular iron uptake through its interaction with iron-bound Tf. TfR1 is often reported to be overexpressed malignant cells, and this increase may associated poor prognosis different types of cancer, which makes it an attractive target for antitumor therapy. marine natural product Muriceidine A potent anticancer agent our previous work. In study, we designed synthesized series derivatives described the systematic investigation into their...
Abstract mRNA immunotherapies have gained interest for the treatment of tumors from various origins, however, their ability to provide long -term durable tumor control has been underwhelming. Here we report that novel lipid nanoparticle (LNP) vaccinations induce robust expansion antigen-specific T cells, although this does not always correlate with infiltrate and kill solid tumors. Using a portfolio ionizable lipids in vivo model reliably identifies LNPs prominent anti-tissue cell activity...
<title>Abstract</title> <bold>Purpose</bold> This study aims to summarize the clinical characteristics of early-stage ovarian clear cell carcinoma (OCCC) patients and establish a predictive model for recurrence. <bold>Methods</bold> A retrospective analysis was conducted on clinical, pathological, prognostic data 129 OCCC treated at Peking University Third Hospital from January 2010 June 2023. Clinical pathological features these were compared summarized. Prognostic factors related...
Background Laryngeal squamous cell carcinoma (LSCC) is the most common type of head and neck carcinoma. However, there are currently no reliable biomarkers for diagnosis prognosis LSCC. Thus, this study aimed to identify independent risk factors develop validate a new dynamic web-based nomogram that can predict auxiliary laryngeal carcinogenesis. Methods Data on medical history 221 patients who were recently diagnosed with LSCC 359 benign lesions (BLLs) at First Affiliated Hospital Anhui...
Objective To explore the main factors affecting medical expenses of patients with colorectal cancer(CRC)and reduce such by optimizing clinical pathway CRC according to influencing factors.Methods Data 467 discharged and insured at Shanghai Cancer Center,Fudan University,were collected from 2009 2010.A multiple linear regression model was applied analyze expenses.The optimized,and before after optimization were compared.Results Our data found days stay complications had impact on...
Abstract Emerging advances in cancer therapy have transformed the landscape from conventional therapies towards immunotherapy regimens. Recent discoveries resulted development of clinical immune checkpoint inhibitors that are ‘game-changers’ for immunotherapy. Here we show eEF2K, an atypical protein kinase inhibits elongation stage synthesis, actually promotes synthesis PD-L1, which helps cells to escape immunosurveillance. Ablation eEF2K prostate and lung markedly reduced expression levels...