A5100360165- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
- Neurological Disease Mechanisms and Treatments
- PARP inhibition in cancer therapy
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Ovarian cancer diagnosis and treatment
- Alzheimer's disease research and treatments
- Cancer Immunotherapy and Biomarkers
- Lymphoma Diagnosis and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Retinal Diseases and Treatments
- Glioma Diagnosis and Treatment
- Ion Channels and Receptors
- Analytic Number Theory Research
- Immune cells in cancer
- Adenosine and Purinergic Signaling
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- HER2/EGFR in Cancer Research
- Cell Adhesion Molecules Research
- Paraquat toxicity studies and treatments
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Sphingolipid Metabolism and Signaling
- Tea Polyphenols and Effects
Guangzhou University of Chinese Medicine
2023-2025
Jiamusi University
2025
First Affiliated Hospital of Jiamusi University
2025
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2025
Second Affiliated Hospital of Dalian Medical University
2017-2024
Dalian Medical University
2017-2024
First Hospital of China Medical University
2024
China Medical University
2024
Tianjin Medical University Cancer Institute and Hospital
2021-2024
First Affiliated Hospital of Xi'an Jiaotong University
2015-2023
Retinitis pigmentosa (RP) is a photoreceptor-degenerative disease caused by various mutations and characterized death of rod photoreceptor cell followed gradual cone photoreceptors. The molecular mechanisms that lead to are not yet fully understood. Neuroinflammation contributes the progression many chronic neurodegenerative disorders. However, it remains be determined how microglia contribute disruption in RP. In this study, we explored role as contributor degeneration rd10 mouse model...
Immunotherapy and chemotherapy combinations have shown activity in endometrial cancer, with greater benefit mismatch repair (MMR)-deficient (dMMR) than MMR-proficient (pMMR) disease. Adding a poly(ADP-ribose) polymerase inhibitor may improve outcomes, especially pMMR
Microglial NADPH oxidase (Nox2) plays a key role in chronic neuroinflammation and related dopaminergic neurodegeneration Parkinson's disease (PD). However, the mechanisms behind Nox2 activation remain unclear. Here, we revealed critical of complement receptor 3 (CR3), microglia-specific pattern recognition receptor, subsequent by using paraquat maneb-induced PD model. Suppression or genetic deletion CR3 impeded microglial Nox2, which was associated with attenuation neurodegeneration....
Neuroinflammation underlies a wide variety of pathological processes in the central nerve system (CNS). Although previous experimental and clinical studies indicate that activation neuroinflammatory signaling occurs early glaucoma, mechanisms controlling microglia are still poorly defined. In present study, we investigated role chemokine receptor Cx3cr1 retinal ganglion cell (RGC) death an mouse glaucoma model with transient elevation intraocular pressure (IOP). We demonstrated played...
Astrogliosis has long been recognized in Parkinson's disease (PD), the most common neurodegenerative movement disorder. However, mechanisms of how astroglia become activated remain unclear. Reciprocal interactions between microglia and play a pivotal role regulating activities astroglia. The purpose this study is to investigate mechanism by which regulate astrogliosis using lipopolysaccharide (LPS) 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse PD models. We found that...
The objective of this study was to evaluate the impact occupation and education level Chinese female breast cancer patients on their staging at diagnosis, clinical pathological features, rate implementation, selection treatment. medical charts 4211 confirmed cases diagnosed between 1999 2008, from 7 centers spread across whole China, were reviewed. Data including information patient's sociodemographic status, characteristics, implementation examination treatment modalities analyzed. In...
The recurrence of bladder cancer after surgery with or without chemotherapy remains a major challenge in treatment. Previous studies have shown that transient receptor potential vanilloid 1 (TRPV1) acts as tumor suppressor through inducing apoptosis cells. However, whether activation TRPV1 has any synergistic effects pirarubicin (THP), one main drugs used urinary instillation to improve chemotherapeutic efficacy remained elusive. present study verified was differentially expressed cell...
Background A hypoxic metabolism environment in the tumors is often associated with poor prognostic events such as tumor progression and treatment resistance. In gastric cancer, mechanism of how hypoxia affects microenvironment immunotherapy efficacy remains to be elucidated. Methods We used bulk-mapping method analyze signatures correlated response single-cell dataset. Cellular, pathway, gene were systematically analyzed both bulk validation datasets. Results The most significant cell...
Background: Non–small‐cell lung cancer remains the leading cause of cancer‐related deaths globally, and epidermal growth factor receptor mutations have been identified as crucial drivers disease. Encouragingly, tyrosine kinase inhibitors demonstrated promising clinical outcomes. Nonetheless, emergence resistance to third‐generation EGFR‐TKIs like osimertinib almonertinib is an inevitable challenge. Methods: In this study, we generated almonertinib‐resistant cell lines from H‐1975 HCC827...
Objective The aim of this study was to compare prognostic factors and survival outcomes in patients with primary central nervous system lymphoma (PCNSL). Methods Surveillance, Epidemiology, End Results (SEER) database queried for diagnosed PCNSL between 2000 2019. Between 2019, a total 5,812 were PCNSL, whom 2,175 (37%) ≤ 60 years old 3,637 (63%) >60 old. younger had higher rate being stage I–II, receiving chemotherapy radiotherapy, similar surgery, longer time. most common...
Even though early detection methods and treatment options are greatly improved, chemoresistance is still a tremendous challenge for breast cancer therapy. Breast stem cells (BCSCs) represent subpopulation that central to chemoresistance. We aim investigate the relationship between SLC34A2 in BCSCs identify underlying mechanisms by which regulates BCSCs. Fluorescence Activated Cell Sorting (FACS) analysis showed presence of variable fraction CD44(+)CD24(-) 25 out samples. cultured primary...
Although immune checkpoint inhibitors (ICIs) provide unprecedented survival improvement for patients with advanced non-small cell lung cancer (NSCLC), disease progression inevitably occurs. After ICIs failure, limited data exist on whether ICI-based treatment beyond (TBP) may be beneficial to NSCLC. This retrospective study aimed evaluate the efficacy of this approach in NSCLC and identify potential factors.Patients stage IV who received after failure prior PD-1/PD-L1 inhibitor treatments...
Osteoarthritis (OA) is a common joint disease associated with the aging of population, and it reduces quality life patients. It characterized by destruction articular cartilage secretion inflammatory cytokines. Owing to unclear pathogenesis OA, current treatment methods have significant limitations. Oxidative stress has been revealed play an important role in development OA. Our experiments indicated that levels GSH decreased level MDA increased chondrocytes, which induced ferroptosis...
Shenling Baizhu Powder (SBP) is a traditional Chinese medicine (TCM) prescription, which has the good efficacy on gastrointestinal toxicity. In this study, we used gut microbiota analysis, metabonomics and network pharmacology to investigate therapeutic effect of SBP pyrotinib-induced diarrhea.
Abstract Camellia nitidissima Chi (CNC) is a famous medicinal and edible plant with the name of “Tea for Longevity” in Guangxi province China. In present study, we determined protective effect extract from CNC leaves on H 2 O ‐induced cell injury its underlying mechanisms human neuroblastoma (SH‐SY5Y) cells. The ethyl acetate fraction (CLE, 50–200 μg/ml) treatment significantly increased viability ‐treated SH‐SY5Y cells reduced leakage LDH reversed “U”‐shape manner. It was confirmed by...
Benign prostatic hyperplasia (BPH) is arguably the most common disease in aging men. Although etiology not well understood, chronic inflammation thought to play an important role BPH initiation and progression. Our recent studies suggest that epithelial barrier compromised glandular tissues. The proinflammatory cytokine transforming growth factor beta 1 (TGF-β1) impacts tight junction formation, enhances permeability, suppresses claudin-1 messenger RNA expression cells. However, of its...
In recent years, digital twins havepenetrated into the medical field, bringing revolutionary changes to field. this study, we propose a disease diagnosis algorithm, factorization machine combine product-based neural network (FMCPNN), which is improved on basis of (PNN). PNN an end-to-end (FM) can solve problem data sparseness. But lacks low-order feature interaction, resulting in weak generalization ability. FMCPNN adds second-order interaction part FM PNN, improves performance PNN. be well...
Depression affects people with multiple adverse outcomes, and the side effects of antidepressants are troubling for depression sufferers. Aromatic drugs have been widely used to relieve symptoms fewer effects. Ligustilide (LIG) is main component volatile oil in angelica sinensis, exhibiting an excellent anti-depressive effect. However, mechanisms effect LIG remain unclear. Therefore, this study aimed explore exerting We obtained 12,969 depression-related genes 204 targets by a network...
Abstract Diffuse large B-cell lymphoma (DLBCL) is the leading cause of mortality from invasive hematological malignancies worldwide. MicroRNA-7-5p (miR-7-5p) has been shown to be a tumor suppressor in several types tumors. However, its role DLBCL not fully understood. This study explored miR-7-5p progression and pursued underlying mechanism. Quantitative real-time PCR transfection miRNA mimic inhibitors were used assess effects on autophagy apoptosis SU-DHL-4 SU-DHL-10 cells. Dual-luciferase...
<h3>Introduction/Background</h3> Combination of immunotherapy with carboplatin/paclitaxel (CP) has demonstrated improved progression-free survival (PFS) and overall (OS) in patients advanced endometrial cancer. The Phase III DUO-E/GOG-3041/ENGOT-EN10 trial (NCT04269200) evaluated the addition durvalumab to standard first-line CP, followed by ± olaparib, <h3>Methodology</h3> Patients newly diagnosed Federation Gynecology Obstetrics Stage III/IV or recurrent cancer naïve systemic treatment...