A5002596284- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- Renal cell carcinoma treatment
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
Huazhong Agricultural University
2023-2025
Background A hypoxic metabolism environment in the tumors is often associated with poor prognostic events such as tumor progression and treatment resistance. In gastric cancer, mechanism of how hypoxia affects microenvironment immunotherapy efficacy remains to be elucidated. Methods We used bulk-mapping method analyze signatures correlated response single-cell dataset. Cellular, pathway, gene were systematically analyzed both bulk validation datasets. Results The most significant cell...
Abstract Programmed cell death 1 (PD-1) or PD-ligand (PD-L1) blocker-based strategies have improved the survival outcomes of clear renal carcinomas (ccRCCs) in recent years, but only a small number patients benefited from them. In this study, we identified three inflammatory features through over 1900 autoimmune nephropathy patients-related bulk RNA sequencing, single-cell sequencing analysis, and immunogenic signatures using genomics (TIs), both which are associated with response to immune...