A5049992692- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Breast Cancer Treatment Studies
- Cancer Cells and Metastasis
- Nutritional Studies and Diet
- Global Cancer Incidence and Screening
- CAR-T cell therapy research
- Cancer, Stress, Anesthesia, and Immune Response
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Esophageal and GI Pathology
- Cancer Risks and Factors
- Liver Disease and Transplantation
- COVID-19 Clinical Research Studies
- HER2/EGFR in Cancer Research
- Asthma and respiratory diseases
- COVID-19 and healthcare impacts
- Allergic Rhinitis and Sensitization
- Pancreatic and Hepatic Oncology Research
- Glioma Diagnosis and Treatment
- Breast Implant and Reconstruction
- Dermatology and Skin Diseases
Capital Medical University
2016-2025
Beijing YouAn Hospital
2022-2025
Hangzhou Medical College
2024
Beijing Shijitan Hospital
2014-2022
Peking University Cancer Hospital
2018-2020
Peking Union Medical College Hospital
2013-2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2020
Peking University
2010-2020
Chinese People's Liberation Army
2020
Central South University
2017
CMTM6, a previously uncharacterized protein, was identified as critical regulator of PD-L1, which is reported an immune checkpoint inhibitor, to modulate the T cell activities both in vitro and vivo other tumors. However, role CMTM6 has so far remained unclear glioma. To investigate gliomas, we analyzed transcriptome level, genomic profiles its relationship with clinical practice. 1862 glioma samples data were enrolled this study, including CGGA RNA-seq, TCGA CGGA-microarray, GSE16011 IVY...
Abstract In China, breast cancer is currently the most common malignancy and sixth leading cause of death in women. But, characteristics whole population are not determined. The aim this study was to perform a detailed on pathologic representing China during 1999–2008 compare difference invasive between Western Chinese. We randomly collected 4,211 inpatient at seven hospitals representative geographical regions 1999–2008. All had ability comprehensive treatment. characters including estrogen...
The objective of this study was to evaluate the impact occupation and education level Chinese female breast cancer patients on their staging at diagnosis, clinical pathological features, rate implementation, selection treatment. medical charts 4211 confirmed cases diagnosed between 1999 2008, from 7 centers spread across whole China, were reviewed. Data including information patient's sociodemographic status, characteristics, implementation examination treatment modalities analyzed. In...
As one of its responses to the increasing global burden breast cancer (BC), China has deployed a national registration and BC screening campaign. The present report describes these programs initial results control strategies, highlighting challenges be considered.The primary incidence prevalence data were obtained from Chinese National Central Cancer Registry. MapInfo software was used map geographic distribution variation. time trends estimated by annual percentage change 2003 2009....
The prevalence of atopic dermatitis (AD) has increased substantially. Previous studies have focused mostly on pediatric patients, while epidemiological investigation adult AD been very limited. aim this study was to determine the and clinical features in outpatients with eczema China mainland. A multicenter cross-sectional conducted among or from 39 tertiary hospitals 15 provinces July 1 September 30, 2014. Of 8758 407 were AD. Compared adults other types dermatitis, mean age (41.8 ± 14.3 vs...
Sodium/hydrogen exchanger 1 (NHE1), encoded by the SLC9A1 gene (SoLute Carrier family 9A1) in humans, is main H+ efflux mechanism maintaining alkaline intracellular pH (pHi) and Warburg effects glioma. However, to date, there are no clinical studies exploring pharmacological inhibition of NHE1 protein cancer treatment. In this study, we investigated expression gliomas its relationship with glioma outcome.The Chinese Glioma Genome Atlas (CGGA) dataset containing transcriptome sequencing data...
The immune checkpoint inhibitor is approved for breast cancer treatment, but the low expression of PD-L1 limits immunotherapy. CD155 another protein in cancers and interacts with ligands to regulate microenvironment. This study aimed at investigating association prognosis pathological features cancer. 126 patients were recruited this cohort consecutively, on tumor cells was detected by immunohistochemistry. Kaplan-Meier survival curve Cox hazard regression model used estimate association....
Glioblastoma multiforme (GBM) is an aggressive and lethal primary brain tumor with limitedtreatment options due to its resistance conventional therapies immunosuppressive microenvironment. In this study, we investigated whether clofazimine, inhibitor of the Wnt/β-catenin signaling pathway, could enhance efficacy anti-PD-1 immunotherapy in GBM. Our vitro vivo experiments demonstrated that clofazimine suppressed GBM cell proliferation, induced apoptosis, inhibited invasion by downregulating...
Breast cancer is the second leading cause of cancer-related deaths among women worldwide. Many patients suffer from bone metastasis. Sclerostin, a key regulator normal remodeling, critically involved in osteolytic diseases. However, its role breast metastasis remains unknown. Here, we found that sclerostin was overexpressed tumor tissues and cell lines. Inhibition by antibody (Scl-Ab) significantly reduced migration invasion MDA-MB-231 MCF-7 cells time- dose-dependent manner. In xenograft...
Objective This study was conducted to assess the reproducibility and validity of a food frequency questionnaire (FFQ) that developed overall dietary consumption via pattern method in rural population southwest China. Methods A total 179 participants aged between 40 70 years old were included this study. Participants administered FFQ at baseline (FFQ1) one year later (FFQ2) reproducibility. Six 3-day 24-hour recalls (24HRs) completed administrations two FFQs determine validity. Dietary...
Background Since the outbreak of coronavirus disease 2019 (COVID-19), studies have found correlations between blood cell count-derived inflammatory markers (BCDIMs) and severity prognosis in COVID-19 patients. However, there is currently a lack systematic comparisons procalcitonin (PCT), C-reactive protein (CRP), protein-to-albumin ratio (CAR) BCDIMs for assessing
This study was conducted to investigate the association between consumption of processed foods and esophageal cancer risk. A population-based case-control designed. For present study, 254 patients with squamous cell carcinoma pathological diagnoses were selected from Yanting during 2008 2010 community-based controls same area, individually matched cases by age sex. Data on demographic, lifestyle dietary factors collected using food frequency questionnaires. conditional logistic regression...
This study aimed to investigate the prognostic value of PD-L1 in Chinese patients with non-small cell lung carcinoma (NSCLC).In this retrospective study, 97 NSCLC were consecutively recruited. The expression profiling PD-1, PD-L1, p53 and Ki-67 was detected by immunohistochemistry. Median survival time estimated Kaplan-Meier curve log-rank test. Risk factors evaluated Cox Proportional Hazards regression models.The median tumor size larger (3.5 cm) among positive expression, compared those...
ABSTRACT China has experienced dramatic industrialization, urbanization, and economic growth over the last 3 decades. The rapid transformation prosperity of industries in rural areas have, turn, created tremendous challenges for occupational health safety (OHS). This article was prepared to address issues township- village-owned enterprises (TVEs) from several aspects, including working conditions workplace hazards, major recognized OHS problems, implications TVE environmental health,...
Introduction Hormone receptors, human epidermal growth factor receptor 2 and some risk factors determine therapies prognosis of breast cancer. The distributed differently between patients with receptors. This study aimed to investigate the distribution subtypes cancer by 3 receptors in Chinese native women a large sample size. Methods multi-center analyzed 4211 patient medical records from 1999 2008 7 regions China. Data on patients' demographic information, (menopausal status, parity, body...
Squamous cell carcinoma of esophagus (ESCC) is one the most common cancers in China. Preserved vegetables are processed foods, consumed high amounts risk areas for ESCC. This study aimed to investigate relationships preserved vegetable consumption with SCC and precancer lesions.Cases from Yanting cancer hospital pathological diagnosis primary cancer, along controls individuals diagnosed lesions by endoscopy iodine staining were interviewed. Trained staff collected data on dietary habits 1...