Jin‐Hu Fan
A5023397446- Esophageal Cancer Research and Treatment
- Breast Cancer Treatment Studies
- Folate and B Vitamins Research
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Esophageal and GI Pathology
- Global Cancer Incidence and Screening
- RNA modifications and cancer
- Cancer Risks and Factors
- Nutritional Studies and Diet
- HER2/EGFR in Cancer Research
- Cancer-related gene regulation
- Vitamin D Research Studies
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Screening and Detection
- Liver Disease Diagnosis and Treatment
- Antioxidant Activity and Oxidative Stress
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Breast Lesions and Carcinomas
- Vitamin C and Antioxidants Research
- Advanced Breast Cancer Therapies
- Oral Health Pathology and Treatment
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Chinese People's Liberation Army
2024
Chengdu University of Traditional Chinese Medicine
2024
Beijing Electronic Science and Technology Institute
2024
Peking Union Medical College Hospital
2013-2023
National Cancer Center
2023
BeiGene (China)
2020-2023
ProQuest (United States)
2021
National Institute of Diabetes and Digestive and Kidney Diseases
2021
First Affiliated Hospital of GuangXi Medical University
2021
Esophageal cancer incidence and mortality rates in Linxian, China are among the highest world. We examined risk factors for esophageal squamous cell carcinoma (ESCC), gastric cardia (GCC), noncardia (GNCC) a population-based, prospective study of 29,584 adults who participated Linxian General Population Trial. All participants completed baseline questionnaire that included questions on demographic characteristics, personal family history disease, lifestyle factors. After 15 years follow-up,...
BackgroundThe General Population Nutrition Intervention Trial was a randomized primary esophageal and gastric cancer prevention trial conducted from 1985 to 1991, in which 29 584 adult participants Linxian, China, were given daily vitamin mineral supplements. Treatment with "factor D," combination of 50 μg selenium, 30 mg E, 15 beta-carotene, led decreased mortality all causes, overall, cancer. Here, we present 10-year follow-up after the end active intervention.
Abstract Background According to the very limited cancer registry, incidence and mortality rates for female breast in China are regarded be increasing especially metropolitan areas. Representative data on profile of Chinese women its time trend over years relatively rare. The aims current study illustrate span explore treatment approaches cancer. Methods This was a hospital-based nation-wide multi-center retrospective primary cases. divided into 7 regions according geographic distribution;...
Background Tobacco smoking is a major risk factor for many diseases. We sought to quantify the burden of tobacco-smoking-related deaths in Asia, parts which men's prevalence among world's highest. Methods and Findings performed pooled analyses data from 1,049,929 participants 21 cohorts Asia risks total cause-specific mortality associated with tobacco using adjusted hazard ratios their 95% confidence intervals. then estimated smoking-related adults aged ≥45 y 2004 Bangladesh, India, mainland...
<h3>Importance</h3> Asia is home to the largest diabetic populations in world. However, limited studies have quantified association of diabetes with all-cause and cause-specific mortality Asian populations. <h3>Objectives</h3> To evaluate investigate potential effect modifications diabetes-mortality associations by participants’ age, sex, education level, body mass index, smoking status. <h3>Design, Setting, Participants</h3> This pooled analysis incorporated individual participant data from...
The human upper digestive tract microbial community (microbiota) is not well characterized and few studies have explored how it relates to health. We examined the relationship between microbiota two cancer-predisposing states, serum pepsinogen I/pepsinogen II ratio (PGI/II; predictor of gastric cancer risk) esophageal squamous dysplasia (ESD; precursor lesion cell carcinoma; ESCC) in a cross-sectional design.The Human Oral Microbe Identification Microarray was used test for presence 272...
To estimate the proportion of liver cancer cases and deaths due to infection with hepatitis B virus (HBV), C (HCV), aflatoxin exposure, alcohol drinking smoking in China 2005.Systemic assessment burden five modifiable risk factors on occurrence using population attributable fraction.We estimated fraction caused by prevalence data around 1990 relative risks from meta-analyses, large-scale observational studies. Liver mortality were 3rd National Death Causes Survey, incidence registries a...
Abstract To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data 38,303 women from cancer genome-wide association studies (20,878 cases and 17,425 controls) detected 124 mosaic X events >2 Mb in 97 (0.25%) women. Here show rates for X-chromosome are four times higher than mean autosomal rates; more often include entire participants with likely harbour events. frequency increases age (0.11% 50-year olds; 0.45% 75-year olds), as...
Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This harbors the TERT and CLPTM1L genes; former encodes catalytic subunit telomerase reverse transcriptase latter may play role in apoptosis. To investigate further genetic architecture common susceptibility this region, we conducted an agnostic subset-based meta-analysis (association analysis based subsets) across six 34 248 cases 45 036...
// Jin-Hu Fan 1, * , Yu-Qing Zhang Su-Sheng Shi 2 Yuan-Jia Chen 3 Xing-Hua Yuan 4 Li-Ming Jiang 5 Shao-Ming Wang 1 Li Ma 6 Yu-Tong He 7 Chang-Yan Feng 8 Xi-Bin Sun 9 Qing Liu 10 Katrina Deloso 11 Yihebali Chi 12 and You-Lin Qiao Department of Cancer Epidemiology, Hospital, Chinese Academy Medical Sciences & Peking Union College Pathology, Gastroenterology, College, Abdominal Surgery, Radiology, Dalian University Hebei Registry, the Fourth hospital medical university Nutrition, Chongqing...
Tuberculosis (TB) remains a major global health threat. Mass screening effectively detects hidden TB cases and latent tuberculosis infections (LTBI), crucial for prevention. This study aims to use IFN-γ release assay (IGRA) in Deqing elderly reveals LTBI cases, explore the risk factors influencing clustering of LTBI. A cross-sectional was conducted 2023 among residents (aged 60 years or above) County using IGRA test (AIMTB). Participants were sampled from 13 towns sub-districts proportional...
In a cohort of 29 584 residents Linxian, China, followed from 1985 to 2001, we conducted case–cohort study the magnitude association Helicobacter pylori seropositivity with cancer risk in random sample 300 oesophageal squamous cell carcinomas, 600 gastric cardia adenocarcinomas, all 363 diagnosed non-cardia and entire (N=1050). Baseline serum was evaluated for IgG antibodies whole-cell CagA H. antigens by enzyme-linked immunosorbent assay. Risks both cancers were increased individuals...
The DNA repair pathways help to maintain genomic integrity and therefore genetic variation in the could affect propensity develop cancer. Selected germline single nucleotide polymorphisms (SNPs) have been associated with esophageal cancer gastric (GC) but few studies comprehensively examined pathway genes. We aimed investigate associations between genes risk of squamous cell carcinoma (ESCC) GC, using data from a genome-wide association study Han Chinese population where ESCC GC are...
Background To estimate the contribution of tobacco smoking, alcohol drinking, low vegetable intake and fruit to esophageal cancer mortality incidence in China. Methodology/Principal Findings We calculated proportion attributable four known modifiable risk factors [population fraction (PAF)]. Exposure data was taken from meta-analyses large-scale national surveys representative samples Chinese population. Data on relative risks were also prospective studies. Esophageal came 3rd death cause...
Abstract Although previous studies have shown that dietary consumption of certain food groups is associated with a lower risk cancer, heart disease and stroke mortality in western populations, limited prospective data are available from China. We prospectively examined the association between intake different at baseline total, outcomes Linxian Nutrition Intervention Trials(NIT) cohort. In 1984–1991, 2445 subjects aged 40–69 years NIT cohort completed frequency questionnaire. Deaths...
Background Colorectal cancer (CRC) is the third most common in China, however, publicly available, descriptive information on clinical epidemiology of CRC limited. Methods Patients diagnosed with primary during 2005 through 2014 were sampled from 13 tertiary hospitals 9 provinces across China. Data related to sociodemographic characteristics, use diagnostic technology, treatment adoption, and expenditure extracted individual medical records. Results In full cohort 8465 patients, mean ± SD...
<h3>Objective:</h3> Low serum pepsinogen I (PGI) and low I/pepsinogen II ratio (PGI/II ratio) are markers of gastric fundic atrophy. We aimed to prospectively test the association between PGI/II risks non-cardia adenocarcinoma, cardia oesophageal squamous cell carcinoma (OSCC). <h3>Design:</h3> Case–cohort study nested in a prospective cohort with over 15 years follow-up. <h3>Setting:</h3> Rural region People's Republic China. <h3>Subjects:</h3> Men women aged 40–69 at baseline. <h3>Main...
1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) exposure has been demonstrated to cause liver tumors in laboratory rodents. DDT's persistent metabolite and environmental degradation product, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), also associated with animals. Whether DDT DDE are hepatocarcinogenesis humans is not clear.We carried out a nested case-control study among the participants of Nutritional Intervention Trials Linxian, China. The case group included 168 individuals...
Abstract In China, breast cancer is currently the most common malignancy and sixth leading cause of death in women. But, characteristics whole population are not determined. The aim this study was to perform a detailed on pathologic representing China during 1999–2008 compare difference invasive between Western Chinese. We randomly collected 4,211 inpatient at seven hospitals representative geographical regions 1999–2008. All had ability comprehensive treatment. characters including estrogen...