A5058594959- Colorectal Cancer Screening and Detection
- Global Cancer Incidence and Screening
- Cervical Cancer and HPV Research
- Gastric Cancer Management and Outcomes
- Reproductive tract infections research
- Diverticular Disease and Complications
- COVID-19 and healthcare impacts
- Genetic factors in colorectal cancer
- Hepatitis B Virus Studies
- Genital Health and Disease
- Colorectal Cancer Surgical Treatments
- Endometrial and Cervical Cancer Treatments
- Molecular Biology Techniques and Applications
- Economic and Financial Impacts of Cancer
- Health Systems, Economic Evaluations, Quality of Life
- Pancreatic and Hepatic Oncology Research
- Plant and animal studies
- Cancer Risks and Factors
- Advances in Oncology and Radiotherapy
- Insect and Pesticide Research
- Genetic diversity and population structure
- Adolescent Sexual and Reproductive Health
- Genomics and Phylogenetic Studies
- Esophageal Cancer Research and Treatment
- Mobile Health and mHealth Applications
Cancer Council NSW
2016-2025
The University of Sydney
2019-2025
National Health and Medical Research Council
2023
The University of Melbourne
2023
UNSW Sydney
2013-2020
Centre International de Recherche sur le Cancer
2019
Albert Einstein College of Medicine
2019
Cancer Council Australia
2017-2019
Cancer Institute of New South Wales
2013-2015
In 2007, Australia was one of the first countries to introduce a national human papillomavirus (HPV) vaccination programme, and it has since achieved high coverage across both sexes. December, 2017, organised cervical screening in transitioned from cytology-based every 2 years for women aged 18-20 69 years, primary HPV testing 5 25-69 exit 70-74 years. We aimed identify earliest which annual age-standardised incidence cancer (which is currently seven cases per 100 000 women) could decrease...
Colorectal cancer screening programmes worldwide have been disrupted during the COVID-19 pandemic. We aimed to estimate impact of hypothetical disruptions organised faecal immunochemical test-based colorectal on short-term and long-term incidence mortality in three countries using microsimulation modelling.In this modelling study, we used four country-specific models-Policy1-Bowel (Australia), OncoSim (Canada), ASCCA MISCAN-Colon (the Netherlands)-to potential COVID-19-related Australia,...
Background Changing colorectal cancer (CRC) incidence rates, including recent increases for people younger than 50 y, need to be considered in planning future control and screening initiatives. Reliable estimates of the impact changing CRC trends on National Bowel Cancer Screening Program (NBCSP) are essential programmatic Australia. An existing microsimulation model CRC, Policy1-Bowel, was updated reproduce Australian data provide projections CRC- screening-related outcomes inform clinical...
BackgroundAustralia's National Cervical Screening Program currently recommends cytological screening every 2 years for women aged 18–69 years. Human papillomavirus (HPV) vaccination was implemented in 2007 with high population coverage, and falls high-grade lesions young have been reported extensively. This decline prompted a major review of the new clinical management guidelines, which we undertook this analysis.MethodsWe did effectiveness modelling an economic assessment potential...
No assessment of the National Bowel Screening Program (NBCSP) in Australia, which considers all downstream benefits, costs, and harms, has been done. We aimed to use a comprehensive natural history model most recent information about cancer treatment costs estimate long-term harms NBCSP (2 yearly immunochemical faecal occult blood testing screening at age 50-74 years) evaluate incremental effect improved participation under different scenarios.In this modelling study, microsimulation model,...
Colorectal cancer is the third most commonly diagnosed in Australia. Emerging evidence from several countries suggests increasing incidence people aged <50 years.We assessed colon and rectal trends 20+ Australia 1982 to 2014. We used data on 375,008 incident cases (248,162 126,846 rectal). quantified annual percentage change (APC) rates by age group using Joinpoint regression.For years, increased mid-2000s, with increase APCs ranging 1.7% 9.3% per annum (depending specific group); early...
A next generation nonavalent human papillomavirus (HPV) vaccine ("HPV9 vaccine") is being introduced in several countries. The aims of this study were to evaluate whether cervical screening will remain cost-effective cohorts offered vaccines and if so, characterize the optimal number tests. We used a dynamic model HPV vaccination cost-effectiveness strategies involving varying numbers primary tests per lifetime for as 12 year-olds. For each four countries-the USA, New Zealand (NZ), Australia...
Many countries are transitioning from cytology-based to longer-interval HPV screening. Trials comparing HPV-based screening cytology report an increase in CIN2/3 detection at the first screen, and longer-term reductions CIN3+; however, population level year-to-year transitional impacts poorly understood. We undertook a comprehensive evaluation of switching primary context vaccination. used Australia as example setting, since will make this transition December 2017.Using model vaccination,...
Background Colorectal cancer (CRC) is the third most common in China, however, publicly available, descriptive information on clinical epidemiology of CRC limited. Methods Patients diagnosed with primary during 2005 through 2014 were sampled from 13 tertiary hospitals 9 provinces across China. Data related to sociodemographic characteristics, use diagnostic technology, treatment adoption, and expenditure extracted individual medical records. Results In full cohort 8465 patients, mean ± SD...
Australia introduced COVID-19 infection prevention and control measures in early 2020. To help prepare health services, the Australian Government Department of Health commissioned a modelled evaluation impact disruptions to population breast, bowel, cervical cancer screening programmes on outcomes services. We used Policy1 modelling platforms predict for potential participation, covering periods 3, 6, 9, 12 mo. estimated missed screens, clinical (cancer incidence, tumour staging), various...
Honeybees are unique in that they the only social insects known to recruit nest mates using waggle dance. This dance is used by successful foragers convey information about both direction and distance food sources. Nest can use this spatial information, increasing their chances of locating source. But how effective bees' communication? Previous work has shown dancing does not benefit a honeybee colony under all foraging conditions benefits small. We an individual-based simulation model...
Abstract Background A new lower-cost rapid-throughput human papillomavirus (HPV) test ( care HPV, Qiagen, Gaithersburg, USA) has been shown to have high sensitivity for the detection of grade cervical intraepithelial neoplasia. Methods We assessed outcomes and cost-effectiveness HPV screening in rural China, compared visual inspection with acetic acid, when used alone (VIA) or combination Lugol's iodine (VIA/VILI). Using data on sexual behaviour, accuracy, diagnostic practices costs from...
Background New Zealand (NZ) is considering transitioning from 3-yearly cervical cytology screening in women 20–69 years (current practice) to primary HPV screening. We evaluated HPV-based both HPV-unvaccinated and cohorts offered vaccination (vaccination coverage ~50%). Methods A complex model of transmission, vaccination, screening, invasive cancer was extensively validated against national population-based datasets. Sixteen potential strategies for were considered. Results Most more...
Objectives: In 2017, the National Cervical Screening Program in Australia will transition to 5-yearly primary HPV screening for all women, irrespective of human papillomavirus (HPV) vaccination status. As an adjunct mainstream program, testing on self-collected samples be offered under practitioner supervision unscreened and underscreened women aged 30–74 years. We quantified how different decisions affect future risk cervical cancer. Design: Simulation outcomes 100 000 previously 30 years...
Screening for colorectal cancer (CRC) decreases burden through removal of precancerous lesions and early detection cancer. The COVID-19 pandemic has disrupted organised CRC screening programs worldwide, with some completely suspending others experiencing significant in participation diagnostic follow-up. This study estimated the global impact disruptions on outcomes, potential effects catch-up screening.Organised were identified 29 countries, data rates COVID-related changes to 2020...
Following a recent major review of cervical screening, from 2017 Australia will transition two-yearly cytology-based screening to five-yearly primary HPV with partial genotyping and direct referral for 16/18 LBC triage other oncogenic types. Switching longer interval result in transitional fluctuations volumes tests before 'steady state' is reached the new test volumes. This study aimed quantify impact this on year-to-year follow-up procedures. Number women screened 2015 2032 were estimated...
The Australian National Bowel Cancer Screening Program (NBCSP) will fully roll-out 2-yearly screening using the immunochemical Faecal Occult Blood Testing (iFOBT) in people aged 50 to 74 years by 2020. In this study, we aimed estimate comparative health benefits, harms, and cost-effectiveness of with iFOBT, versus other potential alternative or adjunctive technologies. A comprehensive validated microsimulation model, Policy1-Bowel, was used simulate a total 13 approaches involving use...
BackgroundFirst generation bivalent and quadrivalent human papillomavirus (HPV) vaccines have been introduced in most developed countries. A next nonavalent vaccine (HPV9) has become available, just as many countries are considering transitioning from cytology-based to HPV-based cervical screening. key driver for the cost-effectiveness of HPV9 will be a reduction screen-detected abnormalities surveillance tests. We aimed evaluate Australia, country with HPV vaccination both sexes that is...