A5000106236- Global Cancer Incidence and Screening
- Colorectal Cancer Screening and Detection
- COVID-19 and healthcare impacts
- Health Systems, Economic Evaluations, Quality of Life
- Economic and Financial Impacts of Cancer
- Lung Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Diverticular Disease and Complications
- Gastric Cancer Management and Outcomes
- Head and Neck Cancer Studies
- Atrial Fibrillation Management and Outcomes
- Advances in Oncology and Radiotherapy
- Cardiac Arrhythmias and Treatments
- Lung Cancer Treatments and Mutations
- Esophageal Cancer Research and Treatment
- Breast Cancer Treatment Studies
- Genetic factors in colorectal cancer
- Healthcare Policy and Management
- Pharmaceutical Economics and Policy
- COVID-19 epidemiological studies
- Ultrasound in Clinical Applications
- Pharmaceutical industry and healthcare
- Mosquito-borne diseases and control
- Neurogenetic and Muscular Disorders Research
- Lung Cancer Research Studies
Canadian Partnership Against Cancer
2020-2024
University of Toronto
2009-2020
McMaster University
2020
University of Ottawa
2020
Statistics Canada
2020
BlueDot (Canada)
2018-2020
St. Michael's Hospital
2012-2019
Canadian Centre for Applied Research in Cancer Control
2012-2016
Cancer Care Ontario
2012-2016
Ottawa Hospital Research Institute
2016
Colorectal cancer screening programmes worldwide have been disrupted during the COVID-19 pandemic. We aimed to estimate impact of hypothetical disruptions organised faecal immunochemical test-based colorectal on short-term and long-term incidence mortality in three countries using microsimulation modelling.In this modelling study, we used four country-specific models-Policy1-Bowel (Australia), OncoSim (Canada), ASCCA MISCAN-Colon (the Netherlands)-to potential COVID-19-related Australia,...
The COVID-19 pandemic has affected cancer care worldwide. This study aimed to estimate the long-term impacts of disruptions on mortality in Canada using a microsimulation model. model simulates incidence and survival incidence, stage at diagnosis data from Canadian Cancer Registry. We modeled reported declines diagnoses treatments recorded provincial administrative datasets March 2020 June 2021. Based literature, we assumed that diagnostic treatment delays lead 6% higher rate death per...
The ongoing economic and political crisis in Venezuela has resulted a collapse of the healthcare system re-emergence previously controlled or eliminated infectious diseases. There also been an exodus Venezuelan international migrants response to crisis. We sought describe disease risks faced by nationals assess mobility patterns migrant population.We synthesized data on recent events among from Venezuela, as well current country residence population. used passenger-level itinerary...
Cancer patients and their families experience considerable financial hardship; however, the current published literature on economic burden of cancer at population level has typically focused costs from health system’s perspective. This study aims to estimate in Canada a societal The analysis was conducted using OncoSim-All Cancers model, Canadian microsimulation model. OncoSim simulates incidence deaths mortality data Registry demography projections Statistics Canada. Using phase-based...
Background and Purpose— Prolonged ambulatory ECG monitoring after cryptogenic stroke improves detection of covert atrial fibrillation, but its long-term cost-effectiveness is uncertain. Methods— We estimated the noninvasive in patients aged ≥55 years a recent negative 24-hour ECG. A Markov model used observed rates fibrillation anticoagulation from randomized controlled trial (EMBRACE) published literature to predict lifetime costs effectiveness (ischemic strokes, hemorrhages, life-years,...
Background The ColonCancerCheck screening program for colorectal cancer (CRC) in Ontario, Canada, is considering switching from biennial guaiac fecal occult blood test (gFOBT) between age 50–74 years to the more sensitive, but also less specific immunochemical (FIT). aim of this study estimate whether additional benefits FIT compared gFOBT outweigh costs and harms. Methods We used microsimulation modeling quality adjusted life (QALYs) gained FIT, no screening, a cohort participants....
Screening for colorectal cancer (CRC) decreases burden through removal of precancerous lesions and early detection cancer. The COVID-19 pandemic has disrupted organised CRC screening programs worldwide, with some completely suspending others experiencing significant in participation diagnostic follow-up. This study estimated the global impact disruptions on outcomes, potential effects catch-up screening.Organised were identified 29 countries, data rates COVID-related changes to 2020...
Background: Yishun Health (YH), a regional population health system in Singapore, has expanded its role beyond healthcare provision to collaboratively care for more than 330,000 residents Northern Singapore with community partners. This prompted transformation towards person-centred Unified Care Model (UCM), delivering through subsidiary integrated Lifelong (LC) and Episodic (EC) models. Experience is critical component of the “Quadruple Aim”, framework measuring whole outcomes. Accordingly,...
Background: Radiotherapy is a common treatment for many cancers, but up-to-date estimates of the costs radiotherapy are lacking. In present study, we estimated unit intensity-modulated (imrt) and 3-dimensional conformal (3D-crt) in Ontario. Methods: An activity-based costing model was developed to estimate imrt 3D-crt prostate cancer. It included equipment, staff, supporting infrastructure. The framework subsequently adapted breast cancer head-and-neck We also tested various scenarios by...
Low-dose computed tomography (CT) screening can reduce lung cancer mortality in people at high risk; adding a smoking cessation intervention to could further improve program outcomes. This study aimed assess the impact of on clinical outcomes, costs and cost-effectiveness.Using OncoSim-Lung mathematical microsimulation model, we compared projected lifetime (nicotine replacement therapy, varenicline 12 wk counselling) context annual low-dose CT for risk without Canada. The simulated...
Abstract Objective To carry out a cost‐effectiveness analysis of omitting chest radiography in the diagnosis infant bronchiolitis. Hypothesis Omitting radiographs typical bronchiolitis was expected to reduce costs without adversely affecting detection rate alternate diseases. Study Design An economic evaluation conducted using clinical and health resources. Emergency department (ED) physicians provided diagnoses pre‐ post‐radiography as well management plan. The primary outcome diagnostic...
Abstract Objectives Disparities in colorectal cancer (CRC) screening uptake by socioeconomic status have been observed Canada. We used the OncoSim-Colorectal model to evaluate health and economic outcomes associated with increasing participation rates of CRC programs 60% among Canadians different income quintiles. Methods Baseline were obtained from 2017 Canadian Community Health Survey. The survey participants categorized into quintiles using their reported household 2016 Census quintile...
Objectives Colorectal cancer (CRC) screening with a faecal immunochemical test (FIT) has been disrupted in many countries during the COVID-19 pandemic. Performing catch-up of missed screens while maintaining regular services requires additional colonoscopy capacity that may not be available. This study aimed to compare strategies clear backlog using limited resources. Methods A range were simulated four country-specific CRC natural-history models: Adenoma and Serrated pathway CAncer (ASCCA)...
OncoSim-Breast is a Canadian breast cancer simulation model to evaluate interventions. This paper aims describe the and how well it reproduces observed trends.The simulates onset, growth, spread of invasive ductal carcinoma in situ tumours. It combines incidence, mortality, screening program, cost data project population-level outcomes. Users can change input answer specific questions. Here, we compared its projections with data. First, model's projected trends Cancer Registry from Vital...
Background: During infectious disease outbreaks with pandemic potential, the number of air passengers travelling from outbreak source to international destinations has been used as a proxy for importation risk new locations. However, evaluations validity this approach are limited. We sought quantify association between travel and using 2014-2016 chikungunya in Americas case study.Methods: country-level data define time period epidemic activity each 45 countries territories reporting 2014...
COVID-19 disrupted cancer control worldwide, impacting preventative screening, diagnoses, and treatment services. This modelling study estimates the impact of disruptions on colorectal cases deaths in Canada Australia, informed by data diagnosis, procedures. Modelling was used to estimate short- long-term effects incidence mortality, including ongoing patient backlogs. A hypothetical mitigation strategy simulated, with diagnostic capacities increased 5% from 2022 address Colorectal screening...