William F. McIntyre
A5058252886- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiac, Anesthesia and Surgical Outcomes
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Syncope and Autonomic Disorders
- Heart Failure Treatment and Management
- Acute Myocardial Infarction Research
- ECG Monitoring and Analysis
- Acute Ischemic Stroke Management
- Hemodynamic Monitoring and Therapy
- Blood Pressure and Hypertension Studies
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiac Arrest and Resuscitation
- Frailty in Older Adults
- Cardiac Structural Anomalies and Repair
- Infective Endocarditis Diagnosis and Management
- Heart Rate Variability and Autonomic Control
- Ultrasound in Clinical Applications
- Intensive Care Unit Cognitive Disorders
Population Health Research Institute
2016-2025
McMaster University
2016-2025
Impact
2018-2025
Hamilton Health Sciences
2016-2025
University of Toronto
2024
University of Manitoba
2014-2022
Oakville Public Library
2017-2022
Western University
2022
Cleveland Research (United States)
2022
Western University of Health Sciences
2022
Long-term continuous electrocardiographic monitoring shows a substantial prevalence of asymptomatic, subclinical atrial fibrillation (SCAF) in patients with pacemakers and cryptogenic stroke. Whether SCAF is also common other without these conditions unknown.We implanted subcutaneous monitors (St. Jude CONFIRM-AF) ≥65 years age attending cardiovascular or neurology outpatient clinics if they had no history but any the following: CHA2DS2-VASc score ≥2, sleep apnea, body mass index >30 kg/m2....
Subclinical atrial fibrillation is short-lasting and asymptomatic can usually be detected only by long-term continuous monitoring with pacemakers or defibrillators. associated an increased risk of stroke a factor 2.5; however, treatment oral anticoagulation uncertain benefit. We conducted trial involving patients subclinical lasting 6 minutes to 24 hours. Patients were randomly assigned in double-blind, double-dummy design receive apixaban at dose 5 mg twice daily (2.5 when indicated)...
Perioperative bleeding is common in patients undergoing noncardiac surgery. Tranexamic acid an antifibrinolytic drug that may safely decrease such bleeding. We conducted a trial involving Patients were randomly assigned to receive tranexamic (1-g intravenous bolus) or placebo at the start and end of surgery (reported here) and, with use partial factorial design, hypotension-avoidance hypertension-avoidance strategy (not reported here). The primary efficacy outcome was life-threatening...
Atrial fibrillation (AF) is a major cause of preventable strokes. Screening asymptomatic individuals for AF may increase anticoagulant use stroke prevention.To evaluate 2 home-based screening interventions.This multicenter randomized clinical trial recruited from primary care practices aged 75 years or older with hypertension and without known AF. From April 5, 2015, to March 26, 2019, 856 participants were enrolled 48 practices.The control group received standard (routine follow-up plus...
BACKGROUND: Device-detected atrial fibrillation (also known as subclinical or high-rate episodes) is a common finding in patients with an implanted cardiac rhythm device and associated increased risk of ischemic stroke. Whether oral anticoagulation effective safe this patient population unclear. METHODS: We performed systematic review MEDLINE Embase for randomized trials comparing antiplatelet no antithrombotic therapy adults device-detected recorded by pacemaker, implantable cardioverter...
Among patients having noncardiac surgery, perioperative hemodynamic abnormalities are associated with vascular complications. Uncertainty remains about what intraoperative blood pressure to target and how manage long-term antihypertensive medications perioperatively.To compare the effects of a hypotension-avoidance hypertension-avoidance strategy on major complications after surgery.Partial factorial randomized trial 2 management strategies (reported here) tranexamic acid versus placebo....
Abstract Background and Aims Mineralocorticoid receptor antagonists (MRAs) improve cardiovascular outcomes in a variety of settings. This study aimed to assess whether cardioprotective effects MRAs are modified by heart failure (HF) atrial fibrillation (AF) status their impact on AF events. Methods MEDLINE, Embase, Cochrane Central databases were searched 24 March 2023 for randomized controlled trials evaluating the efficacy as compared with placebo or usual care reducing events patients at...
Implantable cardioverter defibrillators (ICDs) improve survival in patients at risk for cardiac arrest, but are associated with intravascular lead-related complications. The subcutaneous ICD (S-ICD), no components, was developed to minimize complications.To assess key performance measures related delivery of therapy, including inappropriate shocks (delivered absence life-threatening arrhythmia) and failed (which did not terminate ventricular arrhythmia).Randomized, multicenter trial....
We aimed to summarize existing evidence from published randomized trials that assessed atrial fibrillation (AF) screening for stroke prevention.
Inflammation may promote atrial fibrillation (AF) recurrence after catheter ablation. This study aimed to evaluate a short-term anti-inflammatory treatment with colchicine following ablation of AF.