Mangala Rao
A5052397464- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- HIV Research and Treatment
- Child Nutrition and Water Access
- Phytochemicals and Medicinal Plants
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Blood Pressure and Hypertension Studies
- Anesthesia and Sedative Agents
- COVID-19 Clinical Research Studies
- Leaf Properties and Growth Measurement
- Intelligence, Security, War Strategy
- Food Science and Nutritional Studies
- Global Health and Epidemiology
- Sodium Intake and Health
- Renal Diseases and Glomerulopathies
- Drug-Induced Hepatotoxicity and Protection
- Medicinal Plants and Neuroprotection
- Nutritional Studies and Diet
- Agricultural risk and resilience
- Pneumonia and Respiratory Infections
- Virology and Viral Diseases
- Diphtheria, Corynebacterium, and Tetanus
- Immune Cell Function and Interaction
- Tea Polyphenols and Effects
Indian Council of Medical Research
2005-2023
National Institute of Medical Statistics
2018-2023
St.John's Medical College Hospital
2015-2023
National Health and Medical Research Council
2023
McMaster University
2023
Cleveland Clinic
2022
Walter Reed Army Institute of Research
1999-2021
National Institute of Nutrition
2003-2017
St. John's National Academy of Health Sciences
2012-2015
East Suffolk and North Essex NHS Foundation Trust
1993
Perioperative bleeding is common in patients undergoing noncardiac surgery. Tranexamic acid an antifibrinolytic drug that may safely decrease such bleeding. We conducted a trial involving Patients were randomly assigned to receive tranexamic (1-g intravenous bolus) or placebo at the start and end of surgery (reported here) and, with use partial factorial design, hypotension-avoidance hypertension-avoidance strategy (not reported here). The primary efficacy outcome was life-threatening...
Background & objectives: India witnessed a massive second surge of COVID-19 cases since March 2021 after period decline from September 2020. Data collected under the National Clinical Registry for (NCRC) were analysed to describe differences in demographic and clinical features patients recruited during these two successive waves. Methods: The NCRC, launched 2020, is an ongoing multicentre observational initiative, which provided platform current investigation. Demographic, clinical,...
The development of an effective AIDS vaccine remains a challenge. Nucleoside-modified mRNAs formulated in lipid nanoparticles (mRNA-LNP) have proved to be potent mode immunization against infectious diseases preclinical studies, and are being tested for SARS-CoV-2 humans. A critical question is how mRNA-LNP immunogenicity compares that traditional adjuvanted protein vaccines primates. Here, we show compared elicits either the same or superior magnitude breadth HIV-1 Env-specific...
We compare immunogenicity and protective efficacy of an HIV vaccine comprised env gag DNA Env (Envelope) proteins by co-administration the components in same muscles or separate administration + protein contralateral sites female rhesus macaques. The 6-valent includes gp145 DNAs, representing six sequentially isolated Envs from HIV-infected individual CH505, matching GLA-SE-adjuvanted gp120 proteins. Interestingly, only macaques group are protected against SHIV CH505 acquisition after...
An effective AIDS vaccine continues to be of paramount importance for the control pandemic, and it has been proven an elusive target. Vaccine efficacy trials macaque challenge studies indicate that protection may result combinations many parameters. We show a combination DNA protein vaccinations applied at same time provides rapid robust cellular humoral immune responses evidence reduced risk infection. Vaccine-induced neutralizing antibodies Env V2-specific mucosal sites contribute delay...
Abstract Background For patients undergoing noncardiac surgery, bleeding and hypotension are frequent associated with increased mortality cardiovascular complications. Tranexamic acid (TXA) is an antifibrinolytic agent the potential to reduce surgical bleeding; however, there uncertainty about its efficacy safety in surgery. Although usual perioperative care commonly consistent a hypertension-avoidance strategy (i.e., most continue their antihypertensive medications throughout period...
Abstract Objective To develop a psychometrically valid questionnaire for testing knowledge on micronutrients and to assess the relationship between biomarkers of micronutrient status among adolescents. Design Cross-sectional, institution-based, validity reliability study. Setting Seven higher secondary schools were covered in limits Greater Hyderabad Municipal Corporation, Hyderabad, India. Subjects Students aged 15–19 years, n 92 pre-test, 108 test–retest 109 studying Fe, retinol, ascorbic...
To evaluate the factors associated with mortality of a multicentric cohort hospitalized COVID-19 patients, 0-18 y old, from 42 centers across India.The National Clinical Registry for (NCRC) is an on-going prospective data collection platform enrolling patients diagnosed by real-time PCR or rapid antigen test. The are collected in prestructured e-capture forms. sociodemographic, clinical, laboratory, and hospital outcome 1st September 2020 to 20th February 2022 were analyzed.Of 1244 enrolled...
Idiosyncratic drug-induced liver injury (DILI) is damage to occurring at recommended dose of a drug in contrast toxic or predictable DILI. Although it common first-generation antiepileptic drugs (AEDs), rare newer AEDs such as topiramate. Topiramate commonly causes neurological adverse effects psychomotor slowing and somnolence. Hepatotoxicity by topiramate has been previously reported combination with other valproate carbamazepine. Here, we report case topiramate-induced asymptomatic...
The aim of this work was to design and test a vaccine regimen focusing the immune response on targets associated with infection prevention. We demonstrated that priming DNA expressing only HIV Env V1V2 region induces Ab responses targeting critical in V2 protection. This shows scaffold immunization provides method focus desired target region, absence interference by other epitopes. induced improved recognition epitopes important for protective immunity, namely, V2-specific humoral inversely...
The State of Karnataka experienced drought during the year 2002, resulting fall in agricultural production, food insecurity, acute shortage drinking water and fodder for cattle, reduced employment opportunities (in labour activities) leading to migration individuals neighboring States. It was reported that coverage households work programme, undertaken under relief works poor (10.3%) a family on an average, had opportunity participate these maximum only 3 days entire period. However,...
Pharmacognosy Research,2018,10,3,250-252.DOI:10.4103/pr.pr_153_17Published:July 2018Type:Original ArticleAuthors:Jeffrey Pradeep Raj, John Michael D’Cruz, Tomson Toms, Pradhyumna Muralidharan, and Mangala Rao Author(s) affiliations:Jeffrey D'Cruz, Department of Pharmacology, St. Johns Medical College, Bengaluru, Karnataka, INDIA. Abstract:Background: Withania somnifera (WS), Indian ginseng/ashwagandha, is a common household plant. Its commercially available aqueous or ethanolic root powder...
An innovative approach such as the social marketing strategy (SMS) can be useful for promoting vitamin A status of community. community-based study undertaken in Southern India assessed feasibility and effectiveness SMS raising awareness community concerning A, changing attitudes, improving dietary behaviors. The was adopted experimental area nutrition communication. conventional method education employed positive control area. To changes over time, a negative selected where there no...