A5008063557- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Autoimmune and Inflammatory Disorders Research
- Immune Cell Function and Interaction
- HIV Research and Treatment
- Antifungal resistance and susceptibility
- Peripheral Neuropathies and Disorders
- Antibiotic Resistance in Bacteria
- Liver Disease and Transplantation
- Fungal Infections and Studies
- Parvovirus B19 Infection Studies
- COVID-19 Impact on Reproduction
- Hormonal and reproductive studies
- COVID-19 epidemiological studies
- HIV-related health complications and treatments
- Poisoning and overdose treatments
- Mosquito-borne diseases and control
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Bacterial biofilms and quorum sensing
- Neurological diseases and metabolism
- Nutritional Studies and Diet
- Complement system in diseases
King George's Medical University
2013-2025
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2022
Dr. Reddy's Laboratories (United States)
2014
Of all COVID-19 vaccination-associated adverse events, 2.69% may be neurological in nature. We report the first case of myelitis from India with ChAdOX1 nCoV-19 vaccine; patient had excellent recovery. Having occurred after an administration > 50 million doses, benefits vaccination seem to outweigh risk events.
Coronavirus disease 2019 (COVID-19) has been shown to be associated with a lot of neurological complications, whom Guillain-Barre syndrome (GBS) is an important post-infectious consequentiality. More than 220 patients GBS have reported thus far. We intend share our experience five where one them had severe acute respiratory coronavirus 2 (SARS-CoV-2) in the cerebrospinal fluid (CSF). This first-ever report demonstrating presence SARS-CoV-2 CSF adult patient; similar occurrence recently...
Currently, there is no specific drug for the treatment of coronavirus disease 2019 (COVID-19). Therapeutic benefits intravenous immunoglobulin (IVIG) have been demonstrated in wide range diseases. The present study conducted to evaluate safety and efficacy IVIG COVID-19 patients with moderate pneumonia. An open-label, multicenter, comparative, randomized was on One hundred eligible were 1:1 ratio either receive + standard care (SOC) or SOC. Duration hospital stay significantly shorter group...
The WHO 2021 data estimate that 2 million lives and 53 disability-adjusted life-years were lost in 2019 due to exposures selected chemicals. It is important know the pattern outcome of acute poisoning cases for proper planning, prevention management. Knowing will also help designing training modules primary care physicians make them aware about newer poisons their Awareness regarding consumed necessary early identification, initial management timely referral higher centres by physicians....
Background: Cirrhosis, an advanced stage of liver diseases, induces Cirrhosis-Associated Immune Dysfunction Syndrome (CAIDS) characterized by both innate and adaptive immune dysfunction. Inflammation triggered factors such as alcohol, viruses, toxins, cholesterol induce metabolic reprogramming cells. Our study specifically sought to investigate the compromised response in cirrhosis focusing on assessing T-cell exhaustion activation markers helper cytotoxic T Method: A prospective...
Tenofovir disoproxil fumarate (TDF) is a third-generation nucleoside analogue commonly used as first-line therapy for chronic hepatitis B virus (HBV) infection. However, it associated with nephrotoxicity, which can occur through mechanisms such mitochondrial deoxyribonucleic acid (DNA) depletion and damage to renal tubules. This nephrotoxic effect typically manifests mild increase in serum creatinine decrease phosphate, usually within 4-12 months after starting treatment. Recent studies...
An epidemic of mucormycosis followed the second wave COVID 19 in state Uttar Pradesh, India May 2021. This epidemic, however, had additional challenges to offer form acute shortage all forms amphotericin B, posaconazole and isavuconazole. It was, therefore, planned assess trends minimum inhibitory concentration (MIC) antifungal agents, viz itraconazole terbinafine, provide a template for personalized therapy see whether results could be translated clinically. is an observational,...
Abstract Introduction The clinical and laboratory features of severe COVID‐19 infection overlap with those hemophagocytic lymphohistiocytosis (HLH), a hyperinflammatory disorder often associated several viral infections. syndrome HLH encompasses fever, organomegaly, cytopenias, hyperferritinemia, hypertriglyceridemia, raised transaminases, hypofibrinogenemia, absent natural killer (NK) cell activity, increased soluble CD25 in bone marrow, spleen, lymph nodes. Methods We analyzed...
To evaluate the factors associated with mortality of a multicentric cohort hospitalized COVID-19 patients, 0-18 y old, from 42 centers across India.The National Clinical Registry for (NCRC) is an on-going prospective data collection platform enrolling patients diagnosed by real-time PCR or rapid antigen test. The are collected in prestructured e-capture forms. sociodemographic, clinical, laboratory, and hospital outcome 1st September 2020 to 20th February 2022 were analyzed.Of 1244 enrolled...
Background:: The plasma virome represents the overall composition of viral sequences present in it. Alteration has been reported treatment naïve and immunocompromised (CD4 count < 200) people with HIV (PWH). However, effect ART on PWH preserved CD4 counts is poorly understood. Objective:: We aimed to assess alterations comparison HIV-negative uninfected controls further investigate possible associations viruses inflammation immune dysfunction, namely, immunosenescence exhaustion....
Abstract Despite the effectiveness of COVID-19 vaccination in reducing severity disease, demand for booster is increasing vulnerable populations like elderly and immunocompromised individuals especially with each new wave different countries. There limited data on sustained immunity against patients liver cirrhosis. The study was aimed to compare T cell humoral immune response after 1 year ChAdOx1nCoV-19 Vaccine cirrhosis healthy health care workers (HCW). This a prospective observational...
To assess the efficacy of continuous contactless vital signs monitoring with an automated Early Warning System (EWS) in detecting clinical deterioration among patients general wards.
Carbapenem-resistant Acinetobacter baumannii (CRAb), a major public health threat, causes severe infections in Intensive Care Unit (ICU) patients. It resists β-lactam antibiotics through mechanisms like New Delhi metallo-beta-lactamase (NDM). In ICU patients, 69 species were isolated from 86 non-fermenting Gram-negative bacilli. Isolates identified using biochemical methods and Matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry (MS), carbapenem...
Objective: Human immunodeficiency virus (HIV) infection is known to affect every organ system of the body, either directly or through opportunistic infections. Ours was a cross-sectional study determine prevalence thyroid, adrenal, and gonadal dysfunction in HIV patients correlate these with stages infection, antiretroviral therapy, associated wasting. Design: aged ≥15 years were enrolled from July 2009 June 2010. Each patient underwent thorough clinical evaluation, questionnaire specifying...
The second wave of COVID-19 in India was followed by large number mucormycosis cases. Indiscriminate use immunosuppressive drugs, underlying diseases such as diabetes, cancers, or autoimmune thought to be the cause. However, mortality not high that seen non-COVID mucormycosis.To study detailed characteristics T-cells for evaluating differences T-cell immune dysfunction post-COVID and mucor patients.The included histopathologically confirmed cases (13 post-COVID, 13 non-COVID) 15 healthy...
The hyperinflammatory immune response in severe COVID-19 infection shares features with secondary hemophagocytic lymphohistiocytosis (sHLH) the form of fever, cytopenia, elevated inflammatory markers, and high mortality. There are contrasting opinions regarding utility HLH 2004 or HScore diagnosis COVID-19-related syndrome (COVID-HIS). This was a retrospective study 47 patients infection, suspected to have COVID-HIS 22 sHLH other illnesses, evaluate diagnostic limitations and/or context also...
Haemophagocytic lymphohistiocytosis has been reported as an uncommon complication of severe COVID-19 disease while thrombotic thrombocytopenic purpura rarely reported. Here, we are reporting a 21-year-old man who developed combination these complications during the hospital stay in post-COVID-19 recovery period. He presented with fever and bilateral COVID-19-related pneumonia requiring invasive ventilation. His course was complicated by development pneumothorax, ventilator-associated...
Methyl alcohol poisoning or deaths from drinking illegally brewed cheap which is often spiked with chemicals to increase its potency are frequent in India. Many outbreaks different parts of the country have been reported time time. A total 11,830 lives were lost between 2006 and 2015 due consumption spurious liquor country. The symptoms can range mild severe depending upon factors like amount exposure presentation.The present study was designed describe clinical presentation, management,...
Anabolic-androgenic steroids (AAS) are increasingly being used by athletes and youngsters to become masculine loose body fat. Long-term consumption of AAS causes multiple physical psychological morbidities. Research has also concluded that have addictive potential abuse is commonly found with other substance abuse. Abuse rare in eastern countries. among women even rarer. Here a case report an Indian woman, who was prescribed nandrolone decanoate injections unqualified medical practitioner...