Insulin resistance is one pretty troublesome entity which very commonly aggravates metabolic syndrome. Many methods and indices are available for the estimation of insulin resistance. It essential to test validate their reliability before they can be used as an investigation in patients. At present, hyperinsulinemic euglycemic clamp intravenous glucose tolerance most reliable estimating being a reference standard. Some simple methods, from derived, have been validated e.g. homeostasis model...

Physicians have long recognized the association between diabetes mellitus and several pathologic conditions of hand. The most commonly maladies are limited joint mobility (LJM), Dupuytren's disease (DD), trigger finger (TF), carpal tunnel syndrome (CTS). Incidence these hand disorders has increased in setting diabetes. Collectively, described as diabetic syndrome.The aims were to find out prevalence patients, study relation with microvascular complications.This is an observational...

Diabetic ketoacidosis (DKA) is characterized by a biochemical triad of hyperglycemia, acidosis, and ketonemia. This condition life-threatening despite improvements in diabetic care. The purpose this study was to evaluate the clinical prognostic markers DKA. We assessed correlations with DKA-associated morbidity mortality.Two hundred seventy patients that were hospitalized DKA over period 2 years evaluated clinically laboratory tests. Serial assays serum electrolytes, glucose, blood pH...

Abstract Background and Objective: Cancer of the cervix is a leading cause morbidity mortality among women worldwide. Therefore, to curb disease, there need develop screening test that has good sensitivity specificity. The present study aimed compare effectiveness Pap smear, visual inspection with acetic acid (VIA) Lugol′s iodine (VILI) for mass premalignant malignant lesions cervix; evaluate usefulness VIA VILI as an adjunct improve cervical cytology; role parallel method enhance its...

The primary objective of this study was to determine the serum level antioxidant enzymes and correlate them with outcome in patients aluminum phosphide (ALP) poisoning and, secondly, evaluate effect N-acetylcysteine (NAC) given along supportive treatment ALP poisoning.We conducted a cohort hospitalized at tertiary care center North India. group control were enrolled during period 1 year from May 2011 April 2012.Oxidative stress evaluated each subject by estimating levels enzymes, viz....

Thyroid hormones are known to affect energy metabolism. Many patients of metabolic syndrome have subclinical or clinical hypothyroidism and vice versa. To study the correlation thyroid profile serum lipid with syndrome. It is a hospital based cross sectional case-control carried out in tertiary care health center, we studied functions test 100 according IDF criteria similar number age, gender ethnicity matched healthy controls. We found that HDL was significantly lower (p < 0.001) cases...

Background: Patients suffering from critical illness admitted to the Intensive Care Unit (ICU) exhibit alterations in their thyroid hormone levels, collectively termed as euthyroid sick syndrome or nonthyroidal syndrome. Our study was conducted determine correlation between these changes levels and prognosis of ICU-admitted patients. Methods: A total 270 patients without previous history disorder were included study. We recorded baseline characteristics, acute physiology chronic health...

Pickardt syndrome (Pickardt-Fahlbusch syndrome) is a rare congenital characterized by tertiary hypothyroidism caused the interruption of portal veins between hypothalamus and adenohypophysis. Typical features this are with low thyroid stimulating hormone, hyperprolactinemia other pituitary hormone deficiencies. Pituitary stalk triad thin or interrupted stalk, aplasia hypoplasia anterior absent ectopic posterior (EPP) seen on magnetic resonance imaging (MRI). It anomaly whose exact prevalence...

A total number of 140 type 2 diabetic patients with retinopathy (DR) were enrolled in the study from clinic during May 2011 till June 2012 to determine correlation between severity DR serum lipid and other modifiable risk factors patients. Information including age, sex, height, body weight, mass index (BMI), waist-hip ratio (WHR), systolic diastolic blood pressure was collected each patient. Fasting plasma sugar, low density lipoprotein (LDL), triglyceride level (TG), high (HDL), glycated...

Dengue is the most important mosquito-borne, arboviral infection found in tropical and sub-tropical climates. Clinical presentation varies from a severe flu-like illness to potentially lethal dengue hemorrhagic fever. has been regarded as nonneurotropic virus. However, there are reports describing neurological involvements virus infection. The involvement includes encephalitis, acute disseminated encephalomyelitis, transverse myelitis, Guillain-Barre syndrome. spectrum of patients limited...

Diabetes mellitus is becoming a global health issue with more than 80% diabetics living in developing countries. India accounts for 62.4 million (2011). Indian Council of Medical Research Study (ICMR-INDIAB) study showed highest weighted prevalence rate the north among all studied regions. has many peculiarities aspects from risk factors to control programmers. North Indians are prone diabetes and dyslipidemia because rapid westernization style diet due migration metropolitan cities...

The aim of this observational study was ultrasound evaluation peripheral nerves cross-sectional area (CSA) in subjects with probable diabetic sensorimotor neuropathy (DPN). CSA analyzed reference to clinical and nerve conduction study's (NCS) parameters for early diagnosis pattern involvement.A total 50 patients DPN due Type 2 diabetes age-matched healthy controls underwent sonographic examinations ulnar at the lower arm, median proximal carpal tunnel, common peroneal fibular head, tibial...

Background: Acute febrile encephalopathy (AFE) is a clinical term used to an altered mental state that either accompanies or follows short illness and characterized by diffuse nonspecific brain insult manifested combination of coma, seizures, decerebration. Objective: To identify the etiological diagnosis outcome in adult patients with AFE. Settings Design: A prospective observational study was done aged 14 years above who were admitted AFE at tertiary care center northwest India. Materials...

Thyroid hormone mediates growth and development of the skeleton through its direct effects permissive on hormone. The effect hypothyroidism bone is well described in congenital hypothyroidism, but impact thyroid deficiency a growing skeleton, as it happens with juvenile less defined. In addition, extent to which skeletal defects revert replacement not known. A study was undertaken 29 autoimmune hypothyroid patients manifestations treatment system patients. Hypothyroidism has profound delayed...

Mauriac syndrome is a rare associated with type 1 diabetes (T1DM) in children presenting growth retardation, hepatomegaly, and cushingoid features. Recently, there has been re-emergence of this syndrome, especially the use premix insulin. A 15-year old diabetic boy, who was on insulin erratic blood glucose, referred to us for evaluation short stature. He had significant stature, His hormone (GH) stimulation normal, so overnight dexamethasone suppression test, based which diagnosis reported....

Acanthosis nigricans is a non-specific reaction pattern that may accompany obesity, diabetes, excess corticosteroids, pineal tumors, malignancies, and other endocrine disorders. It considered cutaneous marker of tissue insulin resistance.To determine the prevalence acanthosis in type 2 diabetes mellitus (DM) its correlation with various anthropometric measurements resistance by HOMA-IR metabolic parameters.One hundred fifty consecutive subjects newly diagnosed DM, attending endocrinology OPD...

IntroductIonSepsis is the leading cause of mortality in critically ill.Recent studies emphasize early classification and treatment paramount to improving rates. [1,2]Recently, it has been found many that trace elements nutrients do have an effect on human body if supplemented can improve prognosis patients with sepsis. [1,3]Although role Vitamin D vital immune function sepsis as suggested by studies; this study conducted find out correlation between well whether levels be correlated outcome...

The objective was to determine the role of various components metabolic syndrome (MetS) as independent risk factor for erectile dysfunction (ED).A total 113 subjects MetS, recommended by recent IDF and AHA/NHLBI joint interim statement were selected study who presented ED. After doing Anthropometric examination, fasting laboratory assay plasma glucose (FPG), insulin, hemoglobin A1c, triglyceride (TG), high-density lipoprotein (HDL), low-density (LDL), 2 h oral tolerance test (OGTT) done....

Context: Dengue fever frequently causes thrombocytopenia for which there is no satisfactory treatment. Aim: To evaluate the effect of vitamin E on in dengue fever. Settings and Design: A tertiary teaching hospital during a recent outbreak area. Materials Methods: Patients (as per WHO criteria) with platelet counts between 10 × 3 /mm 100 seen September 1, 2010 to November 30, were enrolled. After detailed history clinical evaluation, patients randomized two groups - group I received 400 mg...

Drugs raise blood glucose concentrations via two broad mechanisms: By reducing insulin biosynthesis or secretion, by tissue sensitivity to insulin.Until date, there have been very few reported cases of isoniazid induced diabetes.We are presenting a case report 6-year-old child with diabetes who was misdiagnosed initially as type 1 mellitus.We hereby stress that before diagnosing patient diabetes-type 2, detailed history drug intake for any such drugs, which can cause hyperglycemia has be...

Reduction of weight in obese type 2 diabetes mellitus (T2DM) individuals is emerging as a significant strategy the reduction proteinuria diabetic nephropathy along with control hyperglycemia, hypertension, and dyslipidemia. The objective was to evaluate 24-h T2DM patients by loss, conventional therapy (angiotensin-converting enzyme [ACE] inhibitors) arm. A prospective, randomized controlled trial conducted between June 2010 May 2011. confirmed urinary protein estimation body mass index (BMI)...