Simmi Dube
A5075485409- Heart Rate Variability and Autonomic Control
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Diabetes Management and Research
- Neuroscience of respiration and sleep
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Antifungal resistance and susceptibility
- Hormonal Regulation and Hypertension
- Diet and metabolism studies
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- SARS-CoV-2 and COVID-19 Research
- Cardiovascular Syncope and Autonomic Disorders
- COVID-19 and Mental Health
- Cardiovascular and exercise physiology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pulmonary Hypertension Research and Treatments
- Diabetes and associated disorders
- Adrenal Hormones and Disorders
- Pharmacology and Obesity Treatment
- Cardiovascular Function and Risk Factors
- melanin and skin pigmentation
- Sinusitis and nasal conditions
- Eicosanoids and Hypertension Pharmacology
- Hormonal and reproductive studies
Gandhi Medical College
2009-2024
Hamidia Hospital
2023
Mayo Clinic in Florida
2014-2017
Mayo Clinic
2013-2015
Michigan State University
2015
Mayo Clinic in Arizona
2014-2015
St James's University Hospital
2015
WinnMed
2014
Indian Institute of Chemical Biology
1983
The accuracy of continuous interstitial fluid (ISF) glucose sensing is an essential component current and emerging open- closed-loop systems for type 1 diabetes. An important determinant sensor the physiological time lag transport from vascular to space. We performed first direct measurement this phenomenon our knowledge in eight healthy subjects under overnight fasted condition. Microdialysis catheters were inserted into abdominal subcutaneous After intravenous bolus administrations...
Background and Objective: The premise of effective closed-loop insulin therapy for type 1 diabetes (T1D) relies on the accuracy continuous interstitial fluid glucose sensing that represents crucial afferent arm such a system. An important determinant sensor is physiological time lag transport from vascular to space. purpose current studies was determine abdominal subcutaneous space in T1D. Method: Four microdialysis catheters were inserted into 6 T1D subjects under overnight fasted...
People with prediabetes are at high risk of developing diabetes.The objective this study was to determine the pathogenesis fasting and postprandial hyperglycemia in prediabetes.Glucose production, gluconeogenesis, glycogenolysis, glucose disappearance were measured before during a hyperinsulinemic clamp using [6,6-(2)H2]glucose deuterated water method corrected for transaldolase exchange.The conducted Mayo Clinic Clinical Research Unit.Subjects impaired (IFG)/normal tolerance (NGT) (n = 14),...
Increased prevalence of type 2 diabetes mellitus and prediabetes worldwide is attributed in part to an unhealthy diet. To evaluate whether 12 weeks high monounsaturated fatty acid (MUFA) or fiber-rich weight-maintenance diet lowers hepatic fat improves glucose tolerance people with prediabetes. Subjects underwent a [6, 6-2H2]–labeled 75-g oral test estimate insulin sensitivity liver fraction (LFF) using magnetic resonance spectroscopy before after intervention. Mayo Clinic Clinical Research...
In the ongoing COVID-19 pandemic, an increased incidence of ROCM was noted in India among those infected with COVID. We determined risk factors for rhino-orbito-cerebral mucormycosis (ROCM) post Coronavirus disease 2019 (COVID-19) never and ever hospitalized separately through a multicentric, hospital-based, unmatched case-control study across India.We defined cases controls as without post-COVID ROCM, respectively. compared their socio-demographics, co-morbidities, steroid use, glycaemic...
Quantitative assessment of the dynamic relationship between plasma and interstitial fluid (ISF) glucose estimation plasma-to-ISF delay are major importance to determine accuracy subcutaneous sensors, an essential component open- closed-loop therapeutic systems for type 1 diabetes mellitus (T1DM). The goal this work is develop a model kinetics from multitracer interstitium data, obtained by microdialysis, in healthy T1DM subjects, under fasting conditions.A specific experimental design,...
Objective Large data on the clinical characteristics and outcome of COVID-19 in Indian population are scarce. We analysed factors associated with mortality a cohort moderately severely ill patients enrolled randomised trial convalescent plasma. Design Secondary analysis from Phase II, Open Label, Randomized Controlled Trial to Assess Safety Efficacy Convalescent Plasma Limit Associated Complications Moderate Disease. Setting 39 public private hospitals across India during study period 22...
In India, the incidence of mucormycosis reached high levels during 2021-2022, coinciding with COVID-19 pandemic. response to this, we established a multicentric ambispective cohort patients hospitalised across India. this paper, report their baseline profile, clinical characteristics and outcomes at discharge. Patients hospitalized for March-July 2021 were included. Mucormycosis was diagnosed based on mycological confirmation direct microscopy (KOH/Calcofluor white stain), culture,...
The role of 11β-hydroxysteroid dehydrogenase types 1 (11β-HSD-1) and 2 (11β-HSD-2) enzymes in sc adipose tissue is controversial.The objective the study was to determine activity 11β-HSD-1 -2 abdominal leg obesity diabetes.11β-HSD-1 enzyme activities were measured by infusing [2,2,4,6,6,12,12-(2)H7] cortisone (D7 cortisone) [9,12,12-(2)H3] cortisol (D3 cortisol) via microdialysis catheters placed fat depots.The conducted at Mayo Clinic Clinical Research Unit.Lean nondiabetic (n = 13),...
Hypoglycemia results in a reduction cardiac baroreflex sensitivity and shift the working range to higher heart rates. This effect is mediated, part, by carotid chemoreceptors. Therefore, we hypothesized hypoglycemia-mediated changes control of rate would be blunted body-resected patients when compared with healthy controls. Five bilateral body resection for glomus tumors 10 controls completed 180-minute hyperinsulinemic, hypoglycemic (≈3.3 mmol/L) clamp. Changes rate, blood pressure,...
What is the central question of this study? Hyperoxia blunts hypoglycaemia counterregulation in healthy adults. We hypothesized that effect mediated by carotid bodies and that: (i) hyperoxia would have no on body-resected patients; (ii) patients exhibit an impaired counterregulatory response to hypoglycaemia. main finding its importance? Our data indicate hypoglycaemic bodies. However, a relatively normal highlights: potential for long-term adaptations after body resection; importance...
Animal studies indicate that glucocorticoids increase hepatic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) expression and activity.Our goal was to determine whether glucocorticoid excess increases cortisol production in the liver via 11β-HSD-1 enzyme pathway humans.A total of mg each [4-(13)C] cortisone [9,12,12-(2)H3] were ingested, [1,2,6,7-(3)H] infused measure C13 (derived from ingested cortisone) turnover using triple tracer technique, whereas glucose measured isotope dilution...
New Findings What is the central question of this study? Activation carotid body chemoreceptors with hypoxia alters baroreceptor‐mediated responses in humans. We aimed to examine whether relationship can be translated other chemoreceptor stimuli (i.e. hypoglycaemia). main finding and its importance? show that hypoglycaemia‐mediated changes heart rate variability baroreflex sensitivity cannot attributed exclusively chemoreceptors; however, play a role resetting working range during...
To evaluate the factors associated with mortality of a multicentric cohort hospitalized COVID-19 patients, 0-18 y old, from 42 centers across India.The National Clinical Registry for (NCRC) is an on-going prospective data collection platform enrolling patients diagnosed by real-time PCR or rapid antigen test. The are collected in prestructured e-capture forms. sociodemographic, clinical, laboratory, and hospital outcome 1st September 2020 to 20th February 2022 were analyzed.Of 1244 enrolled...
The effects of COVID-19 infection persist beyond the active phase. Comprehensive description and analysis post COVID sequelae in various population groups are critical to minimise long-term morbidity mortality associated with COVID-19. This was conducted an objective estimate frequency subsequently, design a framework for holistic management morbidities.Follow-up data collected as part registry-based observational study 31 hospitals across India since September 2020-October 2022 were used...
This study aims to describe the demographic and clinical profile ascertain determinants of outcome among hospitalized coronavirus disease 2019 (COVID-19) adult patients enrolled in National Clinical Registry for COVID-19 (NCRC).NCRC is an on-going data collection platform operational 42 hospitals across India. Data NCRC between 1st September 2020 26th October 2021 were examined.Analysis 29 509 hospitalized, [mean (SD) age: 51.1 (16.2) year; male: 18 752 (63.6%)] showed that 15 678 (53.1%)...