A5021460364- High Altitude and Hypoxia
- Cancer, Hypoxia, and Metabolism
- Neuroscience of respiration and sleep
- Exercise and Physiological Responses
- Adipose Tissue and Metabolism
- COVID-19 Clinical Research Studies
- Phytochemical and Pharmacological Studies
- Venous Thromboembolism Diagnosis and Management
- Cancer-related molecular mechanisms research
- Mitochondrial Function and Pathology
- MicroRNA in disease regulation
- Spaceflight effects on biology
- Heme Oxygenase-1 and Carbon Monoxide
- Gut microbiota and health
- Animal Nutrition and Physiology
- Long-Term Effects of COVID-19
- Medicinal plant effects and applications
- Nanoparticles: synthesis and applications
- RNA modifications and cancer
- Biochemical effects in animals
- Blood Coagulation and Thrombosis Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Metabolomics and Mass Spectrometry Studies
- Plant Physiology and Cultivation Studies
- Circular RNAs in diseases
Defence Institute of Physiology and Allied Sciences
2017-2024
Sri Sathya Sai Institute of Higher Medical Sciences
2024
Defence Research and Development Organisation
2016-2023
Academy of Scientific and Innovative Research
2015-2023
Advanced Systems Laboratory
2023
National Institute for Interdisciplinary Science and Technology
2013-2023
Post Graduate Institute of Medical Education and Research
2023
Banaras Hindu University
2023
Synopsys (United States)
2022-2023
Indian Institute of Technology Roorkee
2023
For nearly a decade, silver nanoparticles (AgNPs) have been the most prevalent commercial nanomaterials products widely used in different biomedical applications due to their broad-spectrum antimicrobial activity. However, poor long-term stability environments, namely, pH, ionic strength, and temperature, cytotoxicity toward mammalian cells has restricted more extensive applications. Hence, there is urgent need develop highly biocompatible, non-toxic, stable for wide-ranging environments In...
Identification of appropriate breeds broilers and development new feed additives is required for the poultry industry at high altitude. Therefore, this experiment was conducted first to identify suitable broiler strain region. One week old chicks (150) from three strains, i.e. Vencobb, RIR cross-bred, Hubbard were randomly selected divided equally into groups. All provided same basal diet. The body weight gain feed: responses significantly (P < 0.05) improved in cross-bred. Mortality also...
Extremes of climate and hypobaric hypoxia cause poor growth performance in broiler chickens at high altitude. The present study examined the potential Hippophae rhamnoides extract as phytogenic feed additive for broilers reared 3500 m above mean sea level (MSL). Higher content phytomolecules were recorded during characterization extract. Immunomodulatory activity was observed chicken lymphocytes through in-vitro studies. Thereafter, vivo study, 105 day old Rhode Island Red (RIR) Cross-bred...
Zinc sulphide (ZnS) nanoparticles, synthesised by a sonochemical route employing zinc chloride and sodium sulphide, displayed significant antifungal properties against the pathogenic yeast Candida albicans (MTCC 227) at minimum fungicidal concentration of 300 μg ml−1. The particles is attributed to generation reactive oxygen species due interaction nanoparticles with water. Additionally, presence Zn in zone inhibition absence effects for large micron sized ZnS suggest size induced effect...
Venous thromboembolism (VTE), a multi-factorial disease, is the third most common cardiovascular disease. Established genetic and acquired risk factors are responsible for onset of VTE. High altitude (HA) also poses as an additional factor, predisposing individuals to VTE; however, its molecular mechanism remains elusive. This study aimed identify genes/pathways associated with pathophysiology deep vein thrombosis (DVT) at HA. Gene expression profiling DVT patients, who developed either sea...
High altitude-induced gastrointestinal (GI) problems are potentially life-threatening. GI tract bleeding and inflammation the major induced by hypobaric hypoxia (HH). In this study, effects of acute exposure to HH up 14 days at 7620 m on immune function have been studied. To fulfill these objectives, Sprague-Dawley (SD) rats were divided into five groups namely Control exposed (1, 3, 7, days). All except control in an animal decompression chamber for respective time intervals. Different...
High-altitude (HA) hypoxia exposure is believed to induce venous thromboembolism (VTE) in otherwise healthy individuals, although this needs be fully established. The present study aims ascertain the role of HA aggravating any predisposition toward VTE and explore whether etiology HA-induced different from that closer sea level. We compared manifestation-matched male patients (HAPs) plains level (SLPs) for 54 parameters, including coagulation-related, fibrinolytic, thrombophilic variables,...
The objective of the study was to find out prophylactic efficacy Quercetin in ameliorating hypoxia induced vascular leakage lungs rats. Male SD rats received different doses quercetin @ 25mg, 50mg, 100mg and 200mg/Kg BW, 1h prior hypobaric exposure (7,620m, for 6h). 50 mg/kg BW supplemented orally considered be optimum dose, due significant reduction (p<0.001) lung water content transvascular compared control (hypoxia, Further, biochemical analysis (ROS, MDA, GSH, GPx, LDH, albumin)...
Enhanced antifungal activity against the yeast species <italic>Candida albicans</italic>, tropicalis</italic> and <italic>Saccharomyces cerevisiae</italic> was displayed by ZnS–ZnO nanocomposites prepared a simple precipitation technique.