A5109975877- Venous Thromboembolism Diagnosis and Management
- High Altitude and Hypoxia
- Blood Coagulation and Thrombosis Mechanisms
- Cancer-related molecular mechanisms research
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Heme Oxygenase-1 and Carbon Monoxide
- Pregnancy and preeclampsia studies
- Genetics and Physical Performance
- Magnetic and Electromagnetic Effects
- Genomics and Phylogenetic Studies
- Intraocular Surgery and Lenses
- Nitric Oxide and Endothelin Effects
- Forensic and Genetic Research
- Retinal and Optic Conditions
- Lipoproteins and Cardiovascular Health
- Retinal and Macular Surgery
- Antiplatelet Therapy and Cardiovascular Diseases
- Neonatal Health and Biochemistry
- Pediatric Hepatobiliary Diseases and Treatments
- MicroRNA in disease regulation
- Acute Ischemic Stroke Management
- Renin-Angiotensin System Studies
Defence Institute of Physiology and Allied Sciences
2011-2023
Nalanda Medical College and Hospital
2023
Tilka Manjhi Bhagalpur University
2008
Significance Hypoxia predisposes otherwise healthy individuals to venous thrombosis, but the underlying mechanism has been unclear. Our study revealed a causal role for nucleotide binding domain, leucine-rich-containing family, pyrin domain containing 3 (NLRP3) inflammasome and IL-1β during hypoxia-induced thrombosis. We further show direct association between NLRP3 hypoxia-inducible factor 1-alpha (HIF-1α) these conditions. Specific interventions within hypoxia–HIF-1α–NLRP3–IL-1β axis in...
Venous thromboembolism (VTE), the third leading cardiovascular complication, requires more understanding at molecular levels. Here, we have identified miR-145 as a key molecule for regulating thrombus formation in venous thrombosis (VT) employing network based bioinformatics approach and vivo experiments. Levels of showed an inverse correlation with load determined by coagulation variables. MiRNA target prediction tools vitro study tissue factor (TF) gene miR-145. The restoration levels...
Outbreak of COVID-19 pandemic in December 2019 affected millions people globally. After substantial research, several biomarkers for have been validated however no specific and reliable biomarker the prognosis patients with infection exists. Present study was designed to identify predict severity tool formulating treatment. A small cohort subjects (n = 43) were enrolled categorized four groups; Dead 16), Severe 10) Moderate 7) healthy controls 10). Small RNA sequencing done on Illumina...
Respiratory pathogens in community-acquired pneumonia are of interest. Hence, adults over 20 years age who arrived at participating institutions' emergency rooms or outpatient clinics with as clinical diagnosis were qualified for participation and evaluated consideration the study. Analysis shows that K. pneumoniae, P. aeruginosa S. pneumoniae was most common bacterial associated pneumonia. Most viral influenza A rhinovirus A.
Venous thromboembolism (VTE), a multi-factorial disease, is the third most common cardiovascular disease. Established genetic and acquired risk factors are responsible for onset of VTE. High altitude (HA) also poses as an additional factor, predisposing individuals to VTE; however, its molecular mechanism remains elusive. This study aimed identify genes/pathways associated with pathophysiology deep vein thrombosis (DVT) at HA. Gene expression profiling DVT patients, who developed either sea...
High-altitude (HA) hypoxia exposure is believed to induce venous thromboembolism (VTE) in otherwise healthy individuals, although this needs be fully established. The present study aims ascertain the role of HA aggravating any predisposition toward VTE and explore whether etiology HA-induced different from that closer sea level. We compared manifestation-matched male patients (HAPs) plains level (SLPs) for 54 parameters, including coagulation-related, fibrinolytic, thrombophilic variables,...
We have analyzed 7,137 samples from 125 different caste, tribal and religious groups of India 99 three populations Nepal for the length variation in COII/tRNA<sup>Lys</sup> region mtDNA. Samples showing were subjected to detailed phylogenetic analysis based on HVS-I informative coding sequence variation. The overall frequencies 9-bp deletion insertion variants South Asia 1.9 0.6%, respectively. also defined a novel deep-rooting haplogroup M43 identified rare H14 Indian carrying...
Studies on different populations have suggested variability in individual susceptibility to altitude sickness depending genetic makeup. The renin–angiotensin–aldosterone system (RAAS) pathway plays a key role regulation of vascular tone and circulatory homeostasis. present study was undertaken investigate the possible association RAAS development high-altitude pulmonary edema (HAPE) lowlanders exposed high altitude. Three categories subjects were selected: individuals who developed HAPE...
The genetic variants linked with the susceptibility of individuals to VTE are well known; however, studies explaining ethnicity based difference in limited. Present study assesses mutations six candidate genes contributing etiology Indian subjects. comprised 93 patients and 102 healthy controls. A PCR-RFLP analysis was performed for nine following associated VTE: favtor V Leiden (FVL), prothrombin, tissue factor pathway inhibitor (TFPI), fibrinogen-beta, plasminogen activator 1 (PAI-1),...
Genes related to endothelial function are responsible for the regulation of vascular functions.The aim this study is investigate whether gene-associated polymorphism and their plasma levels can be used predict risk venous thromboembolism (VTE).We studied 133 patients with VTE 164 healthy controls. Endothelin (EDN) G8002A, EDN T1370G, 3A/4A, eNOSG894T, angiotensin-converting enzyme I/D, growth factor C936T, cell protein C receptor A6936G was genotyped by restriction fragment length...
Biological effect of radiofrequency electromagnetic radiation on the human genome has been a cause growing concern owing to its increased application. In present paper, deoxyribonucleic acid (DNA) personnel working near/in environment (radar operators and radio operators) evaluated. Monomorphic hybridisation profile was thought be particular interest for monitoring subtle changes in DNA, loss or gain sequences, alteration enzyme recognition site, if any, direct assessment allele length...
Venous Thromboembolism (VTE) is a multifactorial disease that infl uenced by individual genetic background and various environmental factors, high altitude (HA) being the one.HA exposure may cause release of several damage associated molecular patterns (DAMPs), which act as ligand for immune receptors.Previous studies on western population involving SNPs analysis TLRs demonstrated are involved in development progression cardiovascular diseases.But, no such study has been done Indian context...
BackgroundPresent study aimed to identify DNA polymorphisms (variants) which can modulate the risk of COVID-19 infection progression severe condition. TaqMan based SNP genotyping assay was performed for 11 single nucleotide (SNPs) in pro-coagulant and anti-coagulant genes.MethodologyA total 33 patients, including dead, moderately infected individuals were compared 35 healthy controls. Both alleles labelled with two different fluorescent dyes (FAM VIC) during formulation. subjects mixed...