A5021165984- Acute Myeloid Leukemia Research
- Blood groups and transfusion
- Hematopoietic Stem Cell Transplantation
- High Altitude and Hypoxia
- Venous Thromboembolism Diagnosis and Management
- Platelet Disorders and Treatments
- Viral-associated cancers and disorders
- Acute Lymphoblastic Leukemia research
- Erythrocyte Function and Pathophysiology
- Heme Oxygenase-1 and Carbon Monoxide
- Blood disorders and treatments
- Lymphoma Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Renal Transplantation Outcomes and Treatments
- Cancer, Hypoxia, and Metabolism
- Heparin-Induced Thrombocytopenia and Thrombosis
- Blood transfusion and management
- Chronic Myeloid Leukemia Treatments
- Acute Ischemic Stroke Management
- Multiple Myeloma Research and Treatments
- Sarcoma Diagnosis and Treatment
- Blood Coagulation and Thrombosis Mechanisms
- Parvovirus B19 Infection Studies
- Hematological disorders and diagnostics
ESIC Hospital
2022-2025
Army Hospital Research and Referral
2013-2023
Creative Commons
2021
Manipal Hospital
2021
Command Hospital
2008-2016
Armed Forces Medical College
2013-2015
Yamagata Research Institute Of Technology
2015
All India Institute of Medical Sciences
2004-2006
Heidelberg University
1999-2001
Significance Hypoxia predisposes otherwise healthy individuals to venous thrombosis, but the underlying mechanism has been unclear. Our study revealed a causal role for nucleotide binding domain, leucine-rich-containing family, pyrin domain containing 3 (NLRP3) inflammasome and IL-1β during hypoxia-induced thrombosis. We further show direct association between NLRP3 hypoxia-inducible factor 1-alpha (HIF-1α) these conditions. Specific interventions within hypoxia–HIF-1α–NLRP3–IL-1β axis in...
Venous thromboembolism (VTE), the third leading cardiovascular complication, requires more understanding at molecular levels. Here, we have identified miR-145 as a key molecule for regulating thrombus formation in venous thrombosis (VT) employing network based bioinformatics approach and vivo experiments. Levels of showed an inverse correlation with load determined by coagulation variables. MiRNA target prediction tools vitro study tissue factor (TF) gene miR-145. The restoration levels...
Abstract Background: Blood and its components have played a central role in patient care. Nothing can replace human blood, the demand for blood outstrips supply. Many factors contribute to shortages, including inadequate donor recruitment, poor inventory management, transportation. This highlights importance necessity of properly utilizing ensuring minimal wastage. Aim: research aims identify reasons waste provide guidelines reducing waste. Materials Methods: retrospective study was...
Venous thromboembolism (VTE), a multi-factorial disease, is the third most common cardiovascular disease. Established genetic and acquired risk factors are responsible for onset of VTE. High altitude (HA) also poses as an additional factor, predisposing individuals to VTE; however, its molecular mechanism remains elusive. This study aimed identify genes/pathways associated with pathophysiology deep vein thrombosis (DVT) at HA. Gene expression profiling DVT patients, who developed either sea...
High-altitude (HA) hypoxia exposure is believed to induce venous thromboembolism (VTE) in otherwise healthy individuals, although this needs be fully established. The present study aims ascertain the role of HA aggravating any predisposition toward VTE and explore whether etiology HA-induced different from that closer sea level. We compared manifestation-matched male patients (HAPs) plains level (SLPs) for 54 parameters, including coagulation-related, fibrinolytic, thrombophilic variables,...
Previous literature suggests that thrombosis is more common in lowlanders sojourning at high altitude (HA) compared to near-sea-level. Though the pathophysiology partly understood, little known of its epidemiology. To elucidate this, an observational prospective longitudinal study was conducted healthy soldiers for months HA. A total 960 male subjects were screened plains, which 750 ascended, altitudes above 15,000ft (4,472m). Clinical examination, haemogram, coagulogram, markers...
The pathophysiology of deep vein thrombosis (DVT) is considered as multifactorial, where thrombus formation an interplay genetic and acquired risk factors. Little known about the expression profile roles long noncoding RNAs (lncRNAs) in human subjects developing DVT at high altitude.Using RNAseQ, we compared peripheral blood mRNA lncRNA high-altitude (HA-DVT) patients with control subjects. We used DESeq to identify differentially expressed (DE) genes. annotated lncRNAs using NONCODE 3.0...
Multiple myeloma (MM) is a plasma cell‑associated cancer and accounts for 13% of all hematological malignancies, worldwide. MM still remains an incurable cell malignancy with poor prognosis due to lack suitable markers. Therefore, discovering novel markers targets diagnosis therapeutics essential. The present study aims identify associated using patient‑derived mononuclear cells (MNCs). Label‑free quantitative proteomics analysis revealed total 192 differentially regulated proteins, in which...
PURPOSE The outcomes of patients with myeloma from developing countries are often lacking because poor record maintenance. Publications such settings also limited the retrospective nature data collection. Information technology can bridge these gaps in real-time We present survival a tertiary care center North India using one indigenously built software. PATIENTS AND METHODS These all presenting to India. patient characteristics (demographics, baseline disease characteristics, risk...
Stroke in the young is attributed to prevalence of thrombophilia, however, reports explaining cause mechanisms from Indian populations are largely not known. The information about association inherited thrombophilia and occurrence stroke still missing. Therefore, we describe here 52 cases ischemic which 22 were recurrent 30 first episode along with an equal number healthy controls. Imaging techniques (CT/MRI/Doppler studies) used identify type location infarcts among various regions brain....
Context: Acute promyelocytic leukemia (APL), an AML subtype, is characterized morphologically by abnormal promyelocytes. Molecular studies show three possible bcr isoforms of PML- RARα fusion gene . This study undertakes analysis PML-RARα and their correlation with hematological parameters response to treatment in Indian patients. Aims: To different patients find any various Settings Design: Patients diagnosed as APL on morphology or flowcytometry confirmed RQ PCR were included the study....
We present the autopsy findings and differential diagnosis in a 42year old male who presented with fever rapidly progressive respiratory symptoms like breathlessness, nonproductive cough right sided chest pain. Initial imaging workup done at our hospital revealed large unilateral tumor tracheal shift. While being evaluated patient developed facial puffiness, tachypnea suggestive of superior vena cava obstruction. Antemortem biopsy lung mass was attempted twice that suggested malignant...
<b>Background:</b> As processing and cryopreservation of cord blood is time consuming costly, it essential to select units with optimal CD34+ cells, total nucleated cell (TNC) number colony forming (CFUs). These are the most important factors affecting outcome UCB transplantation influenced by various maternal neonatal factors. <b>Aim objectives:</b> To determine TNC counts in so as aid proper selection for cryopreservation. <b>Materials Methods:</b> A 100 were collected from normal vaginal...
This study presents the potential of serum metabolomics approach towards segregation multiple myeloma cohort from healthy controls.
Genes related to endothelial function are responsible for the regulation of vascular functions.The aim this study is investigate whether gene-associated polymorphism and their plasma levels can be used predict risk venous thromboembolism (VTE).We studied 133 patients with VTE 164 healthy controls. Endothelin (EDN) G8002A, EDN T1370G, 3A/4A, eNOSG894T, angiotensin-converting enzyme I/D, growth factor C936T, cell protein C receptor A6936G was genotyped by restriction fragment length...